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      • CURRENT SITUATION AND PROSPECT OF SHIPPING INDUSTRY IN VIETNAM

        Le,Thanh Van,Kim,Sung-June 한국항해항만학회 2014 한국항해항만학회 학술대회논문집 Vol.2014 No.춘계

        The report analyze the current situation of shipping industry in Viet Nam, including information about Viet Nam seaborne trade, shipping companies, sea-going fleets, seafarers, major seaports. Afterward it will be disclosed the policy of sea transport in Viet Nam. And finally, the author will give summary and conclusion about shipping industry in Viet Nam.

      • Geotextile Filter의 특수성능 분석

        權武南,李相昊,金勝勳 慶北大學校 1992 論文集 Vol.52 No.-

        In order to lock stability of geotextile filer to clogging or blocking, small scale laboratory tests were accomplished, considering to drainage conditions, on domestic and foreign nonwoven geotextile products used for filter, and permeable capacity of the geotextile filter was analyzed. The results obtained are as follows: 1. The permeable flow rate through the geotextile filter appears to be decrease remarkably in the initial stage of duration time but gradually afterward and is stabilized at 300 hours∼400 hours of duration time. 2. The increase ratio of permeable flow rate through the geotextile filter due to rising hydraulic head appears to be higher with protected soil having lower comparative content of fine particles, and the effect of rising hydraulic head finds to be higher with that protected soil. 3. The permeable flow rate through the geotextile filter appears to be higher with protected soil having lower content of fine particles and the increase of it trends to be considerable and to be decrease according to the elapse of time. From the fact, the flow rate finds to be more influenced by clogging or blocking with protected soil layer having lower content of fine particles. 4. It seems generally that the thicker the geotextile filter is, the higher the permeable flow rate is, but the decrease ratio of it in the initial stage finds to be lower in the case of thicker geotextile.

      • KCI등재

        A Study on the Application of Standards for Clearance of Metal Waste Generated During the Decommissioning of NPP by Using the RESRAD-RECYCLE

        Jong Soon Song,Dong Min Kim,Sang Heon Leε 한국방사성폐기물학회 2016 방사성폐기물학회지 Vol.14 No.4

        원자력발전소 해체 시 발생하는 금속폐기물은 폐기물 중에서 많은 비중을 차지하고 있다. 본 연구에서는 국내 자체처분 규제 요건 및 국내 기관별 자체처분현황을 조사하였다. 실제 원자력발전소 해체 시 발생되는 금속폐기물의 자체처분을 위하여 RESRAD-RECYCLE 코드를 이용하였으며 26가지 시나리오에 대한 선량평가를 수행하였다. 평가결과는 원자력발전소 해체 시 자체처분 및 재활용에 관한 사전자료로서 활용가치가 있을 것으로 사료된다. 추후 자체처분을 통한 처분비용 저감효과 연구가 추가로 가능할 것으로 판단된다. The metal waste generated during nuclear power plant decommissioning constitutes a large proportion of the total radioactive waste. This study investigates the current status of domestic and international regulatory requirements for clearance and the clearance experience of domestic institutions. The RESRAD-RECYCLE code was used for analyzing the clearance of the metal wastes generated during actual nuclear power plant decommissioning, and assessment of the exposure dose of twenty-six scenarios was carried out. The evaluation results will be useful in preliminary analysis of clearance and recycling during nuclear power plant decommissioning. As a next step, the effects of reducing disposal costs by clearance can be studied.

      • SCOPUS

        Tetrahydrobiopterin enhances mitochondrial biogenesis and cardiac contractility via stimulation of PGC1α signaling

        Kim, Hyoung Kyu,Jeon, Jouhyun,Song, In-Sung,Heo, Hae Jin,Jeong, Seung Hun,Long, Le Thanh,Thu, Vu Thi,Ko, Tae Hee,Kim, Min,Kim, Nari,Lee, Sung Ryul,Yang, Jae-Seong,Kang, Mi Seon,Ahn, Jung-Mo,Cho, Je-Yo Elsevier 2019 Biochimica et biophysica acta Vol.1865 No.11

        <P><B>Abstract</B></P> <P>Tetrahydrobiopterin (BH4) shows therapeutic potential as an endogenous target in cardiovascular diseases. Although it is involved in cardiovascular metabolism and mitochondrial biology, its mechanisms of action are unclear. We investigated how BH4 regulates cardiovascular metabolism using an unbiased multiple proteomics approach with a sepiapterin reductase knock-out (<I>Spr</I> <SUP>−/−</SUP>) mouse as a model of BH4 deficiency. <I>Spr</I> <SUP>−/−</SUP> mice exhibited a shortened life span, cardiac contractile dysfunction, and morphological changes. Multiple proteomics and systems-based data-integrative analyses showed that BH4 deficiency altered cardiac mitochondrial oxidative phosphorylation. Along with decreased transcription of major mitochondrial biogenesis regulatory genes, including <I>Ppargc1a</I>, <I>Ppara</I>, <I>Esrra</I>, and <I>Tfam</I>, <I>Spr</I> <SUP>−/−</SUP> mice exhibited lower mitochondrial mass and severe oxidative phosphorylation defects. Exogenous BH4 supplementation, but not nitric oxide supplementation or inhibition, rescued these cardiac and mitochondrial defects. BH4 supplementation also recovered mRNA and protein levels of PGC1α and its target proteins involved in mitochondrial biogenesis (mtTFA and ERRα), antioxidation (Prx3 and SOD2), and fatty acid utilization (CD36 and CPTI-M) in <I>Spr</I> <SUP>−/−</SUP> hearts. These results indicate that BH4-activated transcription of PGC1α regulates cardiac energy metabolism independently of nitric oxide and suggests that BH4 has therapeutic potential for cardiovascular diseases involving mitochondrial dysfunction.</P> <P><B>Highlights</B></P> <P> <UL> <LI> BH4 deficiency impairs mitochondrial and cardiac function. </LI> <LI> BH4 regulates PGC1α, ERRα, and mtTFA transcription. </LI> <LI> BH4 regulates proteins related to mitochondrial antioxidation and fatty acid utilization. </LI> <LI> BH4 is essential for mitochondrial biogenesis and oxidative phosphorylation. </LI> <LI> BH4 has therapeutic potential for cardiovascular diseases involving mitochondrial dysfunction. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>

      • KCI등재

        Single and 28-day Repeated Dose Toxicity Studies of Coumarin in the Minipig

        Sang-Koo Le,Youn-Sang Kweon,Chester D Solis,Shin-Joung Rho,Tae-Ho Kim 한국실험동물학회 2008 Laboratory Animal Research Vol.24 No.3

        The minipig is becoming increasingly used as a test animal both in pharmacological and toxicological studies of new drugs. Coumarin is a natural product which presents in foodstuffs and use in clinical medicine. However, coumarin shows marked toxicity in some species of animals and species differences in toxicity depend on metabolic activation of coumarin. Enzymatic process of coumarin metabolism in minipig is similar to that of human. This study was conducted to compare the toxicity data of coumarin in the minipig with other animal species and to confirm the usefulness of minipig in the regulatory toxicity studies. Single and 28 day repeated-dose toxicity studies of coumarin were conducted using minipigs. In the single dose toxicity study, maximum tolerated dose (MTD) value of coumarin was determined to be a 200 ㎎/㎏/day and liver was decided as a target organ. Based on the single dose toxicity study, twenty-eight day repeated dose study was conducted at dose levels of 0, 50, 100, and 200 ㎎/㎏/day. Middle and high dose minipigs showed clinical signs and pathological lesions in the liver and kidneys. Low dose group minipigs did not display any clinical signs and functional abnormalities considered to have relation with coumarin treatment, but showed significant increase of liver weight. From the above findings, no observable effect level (NOEL) of minipig was determined to be below 50 ㎎/㎏/day.

      • Drift of droplets in aerial spraying for forest pests control

        Sang Myeong Le,Young Hak Jung,Dong Soo Kim,Junheon Kim 한국응용곤충학회 2018 한국응용곤충학회 학술대회논문집 Vol.2018 No.10

        최근 해충방제를 위해 유인헬기와 무인헬기를 이용한 수도작, 과수, 산림 등에서 대면적으로 약제살포가 이루어지고 있는 실정이다. 헬기는 비교적 높은 고도에서 비행하면서 약제를 살포하여 살포여건에 따라 약제가 목적이외의 지역으로 표류하여 부작용을 초래할 수도 있다. 따라서 본 연구는 소나무림의 소나무재선충 매개충과 밤나무림의 종실해충 방제지를 대상으로 유인헬기(소형, 대형)와 무인헬기(드론)의 약제살포 입자의 비산양상을 조사하고 다른 한편으로는 유·무인 헬기를 이용한 약제살포 실연을 통해 입자의 비산 양상을 조사하였다. 방제 실행지 조사에서 유인헬기(대형)의 경우 약제 입자의 최대 비산거리는 100 m였으며, 무인헬기(드론)의 경우 비산거리 30 m인 것으로 나타났다. 유무인 헬기를 이용한 실연 조사에 있어서도 약제입자의 최대 비산거리는 소형헬기의 경우 30 m, 대형헬기의 경우에는 100 m였으며, 드론의 경우에는 30 m로 나타났다. 동일한 조건에서 약제입자는 특정방향으로 비산되는 경향을 보여 풍향의 영향이 크게 미치는 것으로 판단되며 동일한 살포기종에 있어서 조사 시기에 따라 비산거리에 차이를 보이는 것은 약제살포 시간대의 풍속이 크게 영향을 미치는 것으로 판단된다.

      • SCISCIESCOPUS

        Evaluation of a mitochondrial voltage sensor, (18F-fluoropentyl)triphenylphosphonium cation, in a rat myocardial infarction model.

        Kim, Dong-Yeon,Kim, Hyeon-Sik,Le, Uyenchi Nguyen,Jiang, Sheng Nan,Kim, Hee-Jung,Lee, Kyo-Chul,Woo, Sang-Keun,Chung, Jihwa,Kim, Hyung-Seok,Bom, Hee-Seung,Yu, Kook-Hyun,Min, Jung-Joon Society of Nuclear Medicine 2012 The Journal of nuclear medicine Vol.53 No.11

        <P>Radiolabeled lipophilic cationic compounds, such as (18)F-labeled phosphonium salt, accumulate in the mitochondria through a negative inner transmembrane potential. The purpose of this study was to develop and evaluate ((18)F-fluoropentyl)triphenylphosphonium salt ((18)F-FPTP) as a myocardial PET agent.</P>

      • SCISCIESCOPUS

        Surface-modified polymer nanofiber membrane for high-efficiency microdust capturing

        Kim, Han-Jung,Park, Seon Joo,Park, Chul Soon,Le, Thanh-Hai,Hun Lee, Sang,Ha, Tai Hwan,Kim, Hyoung-il,Kim, Jinyeong,Lee, Chang-Soo,Yoon, Hyeonseok,Kwon, Oh Seok Elsevier 2018 Chemical Engineering Journal Vol.339 No.-

        <P><B>Abstract</B></P> <P>Particulate matter (PM) pollution is serious human health issue. Various filter technologies have been developed to improve the air filtration efficiency. Recently, nanofibrous membrane filters have received much attention due to its outstanding transparency and high efficiency for PM ≤ 2.5 μm (PM<SUB>2.5</SUB>) capture/removal compared to conventional micro-structured filters. Although these filters provide high-efficiency PM<SUB>2.5</SUB> capture, obtaining strong PM adhesion via surface engineering remains a challenge. In this study, we demonstrate a high efficiency PM<SUB>2.5</SUB> capture air-filter by electrospun polyacrylonitrile nanofibers (EPNFs). The surface of the EPNFs was modified by oxygen plasma treatment for generating functional groups such as CONH<SUB>2</SUB>, COOH and COOR. The EPNFs were utilized as air filter in hand-made PM removal system which is consisted of DC power supply, PM source, PM sensor and PM removal test chamber. The test result showed high air flow and effective air filtration (PM<SUB>2.5</SUB> removal efficiency: 94.02%, pressure drop: 18 Pa, Time to reach the PM level recommended by the World Health Organization (T<SUB>WHO PM2.5</SUB>): 15 min, quality factor: 0.1564 Pa<SUP>−1</SUP>) compared to commercial filters. The intermolecular interaction between the plasma-treated EPNFs (PEPNFs) and PMs was investigated by density functional theory (DFT) calculations. The PEPNF filter showed high long-term reproducibility in a cycle test with a high PM concentration (over 2,000 μg m<SUP>−3</SUP>). The filter was applied as a car interior air purifier using a cigar jack as a power supply, <I>ca.</I> 16 min was required to reach the PM level recommended by the World Health Organization (<25 μg m<SUP>−3</SUP>).</P> <P><B>Highlights</B></P> <P> <UL> <LI> Surface-modified nanofibers were effective for particulate matter (PM) filtration. </LI> <LI> Intermolecular interaction was studied using density functional theory calculation. </LI> <LI> A car interior air purifier was demonstrated using the nanofiber membrane. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>

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