http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
Hysteresis of concrete-filled circular tubular (CFCT) T-joints under axial load
Liu Hongqing,Shao Yongbo,Lu Ning,Wang Qingli 국제구조공학회 2015 Steel and Composite Structures, An International J Vol.18 No.3
This paper presents investigations on the hysteretic behavior of concrete-filled circular tubular (CFCT) T-joints subjected to axial cyclic loading at brace end. In the experimental study, four specimens are fabricated and tested. The chord members of the tested specimens are filled with concrete along their full length and the braces are hollow section. Failure modes and load-displacement hysteretic curves of all the specimens obtained from experimental tests are given and discussed. Some indicators, in terms of stiffness deterioration, strength deterioration, ductility and energy dissipation, are analyzed to assess the seismic performance of CFCT joints. Test results indicate that the failures are primarily caused by crack cutting through the chord wall, convex deformation on the chord surface near brace/chord intersection and crushing of the core concrete. Hysteretic curves of all the specimens are plump, and no obvious pinching phenomenon is found. The energy dissipation result shows that the inelastic deformation is the main energy dissipation mechanism. It is also found from experimental results that the CFCT joints show clear and steady stiffness deterioration with the increase of displacement after yielding. However, all the specimens do not perform significant strength deterioration before failure. The effect of joint geometric parameters β and γ of the four specimens on hysteretic performance is also discussed.
( He Nan Li ),( Xiao Huan Guo ),( Lu Ning Shao ),( Markus Plate ),( Xiao Ning Mo ),( Yu Wang ),( Wen Ling Han ) 한국생화학분자생물학회 (구 한국생화학회) 2010 BMB Reports Vol.43 No.3
The CKLF-like MARVEL transmembrane domain-containing family (CMTM) is a novel family of proteins linking classical chemokines and the transmembrane 4 superfamily (TM4SF). Our earlier studies indicated several CMTM members (such as CKLF1 and CMTM2) have a secreted form. This is the first report of the secreted form of CMTM5-v1, the major RNA splicing form of CMTM5, which is produced as small vesicles (<100 nm diameter) and floats at a peak density of 1.19 g/ml on continuous sucrose gradients. CMTM5-v1 has no obvious co-localization with CD63 or Golgi complex. In addition, brefeldin A but not wortmannin can inhibit the secretion of CMTM5-v1. Our results suggest that CMTM5-v1 might be secreted via a different vesicle-mediated secretory pathway, which will be helpful for the studies of vesicle-mediated secretion and MARVEL domain-containing proteins. [BMB reports 2010; 43(3): 182-187]
Choi, Sang-Il,Xie, Shuifen,Shao, Minhua,Odell, Jonathan H.,Lu, Ning,Peng, Hsin-Chieh,Protsailo, Lesia,Guerrero, Sandra,Park, Jinho,Xia, Xiaohu,Wang, Jinguo,Kim, Moon J.,Xia, Younan American Chemical Society 2013 Nano letters Vol.13 No.7
<P>Nanoscale Pt–Ni bimetallic octahedra with controlled sizes have been actively explored in recent years owning to their outstanding activity for the oxygen reduction reaction (ORR). Here we report the synthesis of uniform 9 nm Pt–Ni octahedra with the use of oleylamine and oleic acid as surfactants and W(CO)<SUB>6</SUB> as a source of CO that can promote the formation of {111} facets in the presence of Ni. Through the introduction of benzyl ether as a solvent, the coverage of both surfactants on the surface of resultant Pt–Ni octahedra was significantly reduced while the octahedral shape was still attained. By further removing the surfactants through acetic acid treatment, we observed a specific activity 51-fold higher than that of the state-of-the-art Pt/C catalyst for the ORR at 0.93 V, together with a record high mass activity of 3.3 A mg<SUB>Pt</SUB><SUP>–1</SUP> at 0.9 V (the highest mass activity reported in the literature was 1.45 A mg<SUB>Pt</SUB><SUP>–1</SUP>). Our analysis suggests that this great enhancement of ORR activity could be attributed to the presence of a clean, well-preserved (111) surface for the Pt–Ni octahedra.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/nalefd/2013/nalefd.2013.13.issue-7/nl401881z/production/images/medium/nl-2013-01881z_0006.gif'></P><P><A href='http://pubs.acs.org/doi/suppl/10.1021/nl401881z'>ACS Electronic Supporting Info</A></P>
Yang, Xiao-Li,Zhang, Cheng-Dong,Wu, Hua-Yu,Wu, Yong-Hu,Zhang, Yue-Ning,Qin, Meng-Bin,Wu, Hua,Liu, Xiao-Chun,Lina, Xing,Lu, Shao-Ming Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.11
Trichostatin A (TSA) is a histone deacetylase (HDAC) inhibitor. We here investigated its effects on proliferation and apoptosis of the CNE2 carcinoma cell line, and attempted to establish genome-wide DNA methylation alteration due to differentially histone acetylation status. After cells were treated by TSA, the inhibitory rate of cell proliferation was examined with a CCK8 kit, and cell apoptosis was determined by flow cytometry. Compared to control, TSA inhibited CNE2 cell growth and induced apoptosis. Furthermore, TSA was found to induce genome-wide methylation alteration as assessed by genome-wide methylation array. Overall DNA methylation level of cells treated with TSA was higher than in controls. Function and pathway analysis revealed that many genes with methylation alteration were involved in key biological roles, such as apoptosis and cell proliferation. Three genes (DAP3, HSPB1 and CLDN) were independently confirmed by quantitative real-time PCR. Finally, we conclude that TSA inhibits CNE2 cell growth and induces apoptosis in vitro involving genome-wide DNA methylation alteration, so that it has promising application prospects in treatment of NPC in vivo. Although many unreported hypermethylated/hypomethylated genes should be further analyzed and validated, the pointers to new biomarkers and therapeutic strategies in the treatment of NPC should be stressed.