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Kazuhiko Sakamoto,Tomohiro Sakaguchi,Zhaowu Jiang,Tarek Mohamed Naser,Kazuhiko Sekiguchi,Qingyue Wang,Katsuyuki Takahashi 한국대기환경학회 2007 한국대기환경학회 학술대회논문집 Vol.- No.-
To clarify the effect of the Diesel Vehicle Exhaust Gas Regulations enforced by Tokyo Metropolis, Saitama, Kanagawa, and Chiba Prefectures in October, 2003, we compared concentration of various chemical components in size-separated SPM and traffic volume of 2002 or 2003 (before the Regulation) to that of 2003 or 2004 (after the Regulation) at the road site of National Road Route 17 and Prefecture Road Route 57. Generally, decreasing tendency in EC concentration of each particle sizes was found from 2002 and 2003 to 2003 and 2004 sampling periods, respectively. Especially, decrease in average concentration of EC<SUB><2㎛</SUB> was clear. In the next, we analyzed various correlations of chemical components in size-separated SPM and traffic volume. From their results, we concluded decrease of the EC<SUB><2㎛</SUB> concentration at the roadside was caused by this Regulation. Also, we will discuss on long term trend of mass concentrations and chemical composition for SPM and fine particles observed at general environment and around the other trunk roads in the greater Tokyo Metropolitan Area.
Naohiro Sekiguchi,Airi Hamano,Tomoko Kitagawa,Yuya Kurihara,Kenichi Ito,Miwa Kurimoto,Kozo Watanabe,Kazuhiko Hirano,Satoshi Noto,Kazuaki Yamada,Naoki Takezako 대한혈액학회 2018 Blood Research Vol.53 No.2
Background Waldenström Macroglobulinemia (WM) is a rare subtype of indolent B-cell lymphoma, and prospective randomized studies on WM are scarce. The R-CHOP therapy [rituximab (R), cyclophosphamide, hydroxy-doxorubicin, vincristine, and prednisone] is a popular and recommended regimen for primary therapy, prescribed by several treatment guide-lines for WM. However, treatment with R-CHOP is accompanied by severe myelosup-pression and high rates of peripheral neuropathy. Therefore, we retrospectively evaluated the efficacy and toxicity of half-dose CHOP combined with R as a primary therapy for WM. Methods Patients with untreated symptomatic WM, treated at the Disaster Medical Center be-tween April 2011 and September 2016, were retrospectively analyzed after admin-istration of 6 cycles of half-dose R-CHOP for every 3 weeks. The response, median time to response, best response, progression-free survival, overall survival, and toxicities were evaluated. Results Of the 20 WM patients analyzed, 16 (80%) received half-dose R-CHOP without vincris-tine, and 13 (65%) responded to the treatment. With a median follow-up duration of 26.3 months, the 2-year progression-free survival and 2-year overall survival rates were 70 and 93.3%, respectively. The median time to response and best response were 6 and 9.9 weeks, respectively. Grade 3/4 leukocytopenia, neutropenia, febrile neutropenia, and Grade 1 peripheral neuropathy developed in 32, 37, 0, and 21% of patients, respectively. Conclusion The half-dose R-CHOP is an effective and well-tolerated primary therapy for WM. To the best of our knowledge, this is the first study reporting the use of a reduced-dose R-CHOP regimen for the primary treatment of WM.
Naohiro Sekiguchi,Airi Hamano,Tomoko Kitagawa,Yuya Kurihara,Kenichi Ito,Miwa Kurimoto,Kozo Watanabe,Kazuhiko Hirano,Satoshi Noto,Kazuaki Yamada,Naoki Takezako 대한혈액학회 2018 Blood Research Vol.53 No.2
Background Waldenström Macroglobulinemia (WM) is a rare subtype of indolent B-cell lymphoma, and prospective randomized studies on WM are scarce. The R-CHOP therapy [rituximab (R), cyclophosphamide, hydroxy-doxorubicin, vincristine, and prednisone] is a popular and recommended regimen for primary therapy, prescribed by several treatment guide-lines for WM. However, treatment with R-CHOP is accompanied by severe myelosup-pression and high rates of peripheral neuropathy. Therefore, we retrospectively evaluated the efficacy and toxicity of half-dose CHOP combined with R as a primary therapy for WM. Methods Patients with untreated symptomatic WM, treated at the Disaster Medical Center be-tween April 2011 and September 2016, were retrospectively analyzed after admin-istration of 6 cycles of half-dose R-CHOP for every 3 weeks. The response, median time to response, best response, progression-free survival, overall survival, and toxicities were evaluated. Results Of the 20 WM patients analyzed, 16 (80%) received half-dose R-CHOP without vincris-tine, and 13 (65%) responded to the treatment. With a median follow-up duration of 26.3 months, the 2-year progression-free survival and 2-year overall survival rates were 70 and 93.3%, respectively. The median time to response and best response were 6 and 9.9 weeks, respectively. Grade 3/4 leukocytopenia, neutropenia, febrile neutropenia, and Grade 1 peripheral neuropathy developed in 32, 37, 0, and 21% of patients, respectively. Conclusion The half-dose R-CHOP is an effective and well-tolerated primary therapy for WM. To the best of our knowledge, this is the first study reporting the use of a reduced-dose R-CHOP regimen for the primary treatment of WM.
Ricardo Ortiz,Satoru Shimada,Kazuhiko Sekiguchi,Qinyue Wang,Kazuhiko Sakamoto 한국대기환경학회 2013 Asian Journal of Atmospheric Environment (AJAE) Vol.7 No.3
Seven potentially harmful bifunctional carbonyls were measured in particulate and gaseous phases at a roadside site and a suburban site in an area about 30 km north-northwest from Tokyo metropolitan area in the Kanto region in Japan. For the first time, these compounds were measured in both phases with a time resolution of 2 h. We found that wind direction is an important parameter that affects the collection of these compounds near the source, and it can cover the effects of other important variables. Our results confirmed that motor vehicles and especially diesel fuelled vehicles are important sources of these compounds. Photochemical generation is also an important source of these compounds in the gaseous phase. Transportation from the urban area is also important,particularly in the aerosol phase.
Long-term Sulfur Emissions and Environmental Kuznets Curves: Comparison and Implications
Huang, Zheng,Tonooka, Yutaka,Sekiguchi, Kazuhiko,Wang, Qingyue,Sakamoto, Kazuhiko Korean Society for Atmospheric Environment 2009 Asian Journal of Atmospheric Environment (AJAE) Vol.3 No.1
The environmental Kuznets curve hypothesis assumes an inverted U-shaped relationship between environmental damage and income, and such curves have been used to study how economic growth affects the environment. In this study, we analyzed data for gross domestic product (GDP) per capita and for sulfur emissions in the industrialized countries of the United Kingdom, United States of America, and Japan, as well as data for the developing country of China, to determine the relationship between emissions and income in these countries. Attempts by these countries' governments to incorporate environmental policy considerations into the income-environment relationship were also examined. The potential role of the environmental Kuznets curve as a policy tool was investigated. We determined that, at least in the case of sulfur emissions, policies and institutions significantly reduced environmental degradation in the industrialized countries studied. Furthermore, the environmental Kuznets curve can reliably predict the future relationship between environmental impact and GDP for developing countries.
Naser, TarekMohamed,Yoshimura, Yuji,Sekiguchi, Kazuhiko,Wang, Qingyue,Sakamoto, Kazuhiko Korean Society for Atmospheric Environment 2008 Asian Journal of Atmospheric Environment (AJAE) Vol.2 No.2
The chemical compositions of $PM_{2.5}$ and $PM_{10}$ and associated high-molecular-weight polycyclic aromatic hydrocarbons (PAHs) were investigated during winter and summer at a roadside and an urban background site in Saitama, Japan. The average concentrations of $PM_{2.5}$ exceeded the United States Environmental Protection Agency standards during both periods. Carbonaceous components were abundant in both the observed and calculated (by means of a mass closure model) chemical composition of $PM_{2.5}$. Traffic-related pollutants (elemental carbon and high-molecular-weight PAHs) were strongly associated with $PM_{2.5}$ rather than with larger particles. The mass concentrations of $PM_{2.5}$, as well as those of EC and PAHs associated with the particles, at the two sites were strongly correlated. Comparison of our data with source profile ratios indicates that diesel-powered vehicles were probably the main source of the measured PAHs. The PAHs concentrations were affected by meteorological conditions during our study. Our results highlight the need for the establishment of standards for $PM_{2.5}$ in Japan.