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Lee, Myongjae,Kim, Dohee,Shin, Jeongcheol,Lee, Hee-Yeol,Park, Soobong,Lee, Hong-Sub,Kang, Jae-Hoon,Chung, Suk-Jae Elsevier 2017 Journal of pharmaceutical and biomedical analysis Vol.145 No.-
<P><B>Abstract</B></P> <P>IDP-73152, a novel inhibitor of a bacterial peptide deformylase, was recently approved as a new, investigational drug in Korea for the clinical management of infections caused by Gram positive bacteria. The objective of this study was to develop/validate a simple and robust analytical method for the determination of IDP-73152 in plasma samples from rodents and humans, and to assess the feasibility of the assay for use in pharmacokinetic studies using animal models. Plasma samples were processed using a standard method for protein precipitation and an aliquot of the extract then injected onto an UHPLC–MS/MS system. The drug and IDP-117293, an internal standard, were analyzed in the positive ion-mode by electrospray ionization and quantified by monitoring the transition at <I>m</I>/<I>z</I> 555.2→245.2 for IDP-73152 and 563.3→253.1 for the internal standard, respectively. The lower and upper limit of the assay was determined to be 5 and 10000ng/ml, respectively, with an acceptable linearity (<I>R></I> 0.999) in the response-concentration relationship. Validation parameters, including accuracy, precision, dilution, recovery, matrix effect and stability were found to be within the acceptable ranges recommended by the assay validation guidelines of the United States FDA. The method was successfully applied to the quantification of IDP-73152 in plasma from mice/rats that had received a single oral administration of 80mg/kg IDP-73152, in the form of the mesylate salt. These findings suggest that the validated assay can be used in preclinical and clinical pharmacokinetic studies of IDP-73152.</P> <P><B>Highlights</B></P> <P> <UL> <LI> UPLC–MS/MS assay for IDP-73152 was developed in plasma samples from mice/rats/humans. </LI> <LI> The assay was applicable to the pharmacokinetic studies of IDP-73152 in mice and rats. </LI> <LI> The assay can be applied to routine pharmacokinetic studies in humans. </LI> </UL> </P>
Active data dissemination for mobile sink groups in wireless sensor networks
Lee, Jeongcheol,Oh, Seungmin,Park, Soochang,Yim, Yongbin,Kim, Sang-Ha,Lee, Euisin Elsevier 2018 AD HOC NETWORKS Vol.72 No.-
<P><B>Abstract</B></P> <P>In wireless sensor networks, a mobile sink group brings out many challenging issues with regard to data dissemination due to its twofold mobility: group mobility and individual one. All member sinks of a group should move together toward the same destination in relation to the group mobility, but each member sink can also move randomly within a certain group area in relation to the individual mobility. For supporting such groups, geocasting may decrease data delivery ratio due to continuous group area shifting by the group mobility, and multicasting may increase energy consumption due to frequent multicast tree reconstructions by the individual sink mobility. Recently, mobile geocasting protocols have been proposed, which enable a mobile sink group to periodically register its current group area information to a source and member sinks in the group to passively receive data from the source by flooding within the registered group area. However, due to the passive data dissemination, they suffer from excessive energy consumption of sensor nodes due to flooding data within the large group area and result in high data delivery failures of member sinks on edge of the group due to asynchrony between the registered group area and the actual group area. Therefore, we propose an active data dissemination protocol that exploits a local data area constructed by considering the moving direction and pattern of a mobile sink group. In the proposed protocol, a source sends data to nodes in the local data area in advance, and member sinks in the group actively receive the data from the local data area when they potentially pass it. To efficiently construct a local data area, we investigate the pattern of group mobility and classify into three major categories according to the prediction level: a regular movement, a directional movement, and a random movement. We then present three different data dissemination schemes with an efficient local data area to effectively operate for each mobility pattern. Experimental results conducted in various environments show that the proposed protocol has better performance than previous protocols in terms of the data delivery ratio and the energy consumption.</P>
Geographic Multicast Protocol for Mobile Sinks in Wireless Sensor Networks
Euisin Lee,Soochang Park,Jeongcheol Lee,Sang-Ha Kim IEEE 2011 IEEE communications letters Vol.15 No.12
<P>This letter proposes a SInk-initiated Geographic Multicast (SIGM) protocol for mobile sinks in wireless sensor networks. To reduce location updates from sinks to a source and to achieve fast multicast tree construction and data delivery, SIGM allows sinks to construct their own data delivery paths from a source to them and a geographic multicast tree to be automatically constructed by merging the data delivery paths. Then, the source forwards data to the sinks down the multicast tree. This paper also proposes a round-based virtual infrastructure with a radial shape for growing the merging probability of data delivery paths and reducing the reconstruction frequency of the multicast tree due to mobility of sinks.</P>