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( Jehun Kim ),( Changmin Choi ),( Mihyun Kim ),( Sungyong Lee ),( Cheolkyu Park ),( Yoonsoo Chang ),( Kyeyoung Lee ),( Seungjoon Kim ),( Seihoon Yang ),( Jeongseon Ryu ),( Jeongeun Lee ),( Shinyup Lee 대한결핵 및 호흡기학회 2020 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.128 No.-
Introduction We aimed to assess the clinical effect of sequential treatment of afatinib and osimertinib with the use of real-world data in South Korea in patients with non-small cell lung cancer harboring EGFR mutations. Materials and Methods Electronic records of EGFR-mutated NSCLC patients who received first line afatinib and second line osimertinib (group A) or other chemotherapies (group B) between October 2014 and December 2019 across 16 hospitals were reviewed. Primary outcome was to measure time on treatment (TOT), and second outcomes was overall survival (OS). Results Of total 749 patients received frontline afatinib treatment, 322 (134 in group A and 188 in group B) without missing values were selected. Overall median TOT was 32.8 months (95% confidence interval [CI]: 27.3-38.2) in group A and 20.5 months (95% CI: 18.9-22.0) in group B. In group A, presence of hepatic metastasis showed shorter overall median TOT (22.0 months versus [vs]. 39.5 months, P <0.001), and presence of bone metastasis also showed shorter TOT (27.6 months vs. 39.5 months, P = 0.019); However, no significant differences were observed in other characteristics, including EGFR mutation profile (Del 19: 31.0 months vs. L858R: 27.2 months, P = 0.822) and presence of brain metastasis (26.4 months vs. 35.2 months, P = 0.106). In the multivariate analysis of overall TOT, liver metastasis (hazard ratio [HR]: 1.93, 95% CI: 1.06-3.53, P = 0.031) and pericardial metastasis (HR: 2.83, 95% CI: 1.01-7.88) showed poor survival outcome in group A. Conclusion In this real-world experience, sequential treatment with afatinib and osimertinib showed better survival outcome than afatinib treatment followed by other therapeutic regimens. These Results are in line with other previous studies implicating that this sequential treatment may provide sustained clinical benefit to NSCLC patients harboring EGFR mutations, and may warrant further investigations.
Tracheal pleomorphic adenoma with coexisting pulmonary tuberculoma
( Jehun Kim ),( Chul-ho Oak ),( Tae-won Jang ),( Mann-hong Jung ) 영남대학교 의과대학 2018 Yeungnam University Journal of Medicine Vol.35 No.1
Tracheal tumors are rare and difficult to diagnose. Moreover, delays in diagnosis are very common because the symptoms are nonspecific. As a result, tracheal tumors are commonly mistreated as chronic obstructive pulmonary disease or bronchial asthma. We report a case of a 49-year-old male who presented with a 3- month history of dyspnea and cough. Chest computed tomography scan showed a 1.5×1.3 cm homogenous tumor originating from the right lateral wall of the tracheobronchial angle into the tracheal lumen as well as a 0.5×0.4 cm round nodular lesion at the right upper lobe with multiple mediastinal lymph nodes enlargement. Bronchoscopic findings revealed a broad-based, polypoid lesion nearly obstructing the airway of the right main bronchus. The patient was diagnosed with pleomorphic adenoma which is the most common benign tumor of the salivary glands, but rarely appears in the trachea. Upon surgery, tracheal pleomorphic adenoma and co-existing active pulmonary tuberculoma that had been mistreated as bronchial asthma over 3 months was revealed. Following surgery, the patient underwent anti-tuberculosis treatment. No recurrence has been detected in the 3 years since treatment and the patient is now asymptomatic.
쥐오줌풀 추출물의 신경세포주에서 과산화수소로 유도한 산화스트레스 저해
Jehun Choi,Ji Yeon Lee,Young Ock Kim,Ji Hye Yoon,Hyung Don Kim,Yu Su Shin,Young Sup Ahn,Chun Geon Park 한국약용작물학회 2016 한국약용작물학술대회 발표집 Vol.2016 No.10
Background : Reactive oxygen species (ROS), whether produced endogenously as a consequence of normal cell functions or derived from external sources, pose a constant threat to cells living in an aerobic environment as they can result in severe damage to DNA, protein, and lipids. The effects of Valeriana fauriei extract and fractions on hydrogen peroxide-induced neuronal cell damage are studied. Methods and Results : Oxidative stress plays an important role in the pathological process of neurodegenerative diseases. Valeriana fauriei extract (VFE) and EA fractions (VFEA) was investigated total phenolic contents using method. VFE of total phenolic contents had 2.54 ± 0.01 mg/g, also, VFEA had a 18.78 ± 0.03 mg/g. High phenolic content of the VFEA is expected to better the inhibition of oxidative stress. VFE and VFEA were experimented to inhibit ROS induced 200 μM 3-morpholinosydnonimine (SIN-1). VFE of inhibit SIN-1 induced-ROS dose dependently and signficantly. In addition, VFEA inhibition was also dose dependant and significant. Moreover, Treatment of SH-SY5Y and SK-N-SH cells with VFEA significantly reduced hydrogen peroxide-induced generation of intercellular ROS. Conclusion : From the above results, we may suggest that VFEA might have useful as a material for functional food and pharmaceutics for the pathological process of neurodegenerative diseases.
Tracheal pleomorphic adenoma with coexisting pulmonary tuberculoma
Kim, Jehun,Oak, Chul-Ho,Jang, Tae-Won,Jung, Mann-Hong Yeungnam University College of Medicine 2018 Yeungnam University Journal of Medicine Vol.35 No.1
Tracheal tumors are rare and difficult to diagnose. Moreover, delays in diagnosis are very common because the symptoms are nonspecific. As a result, tracheal tumors are commonly mistreated as chronic obstructive pulmonary disease or bronchial asthma. We report a case of a 49-year-old male who presented with a 3-month history of dyspnea and cough. Chest computed tomography scan showed a $1.5{\times}1.3cm$ homogenous tumor originating from the right lateral wall of the tracheobronchial angle into the tracheal lumen as well as a $0.5{\times}0.4cm$ round nodular lesion at the right upper lobe with multiple mediastinal lymph nodes enlargement. Bronchoscopic findings revealed a broad-based, polypoid lesion nearly obstructing the airway of the right main bronchus. The patient was diagnosed with pleomorphic adenoma which is the most common benign tumor of the salivary glands, but rarely appears in the trachea. Upon surgery, tracheal pleomorphic adenoma and co-existing active pulmonary tuberculoma that had been mistreated as bronchial asthma over 3 months was revealed. Following surgery, the patient underwent anti-tuberculosis treatment. No recurrence has been detected in the 3 years since treatment and the patient is now asymptomatic.