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Hydroxyhibiscone A, a Novel Human Neutrophil Elastase Inhibitor from Hibiscus syriacus
( Ryoo In Ja ),( Bong Sik Yun ),( In Kyoung Lee ),( Young Hee Kim ),( Ik Soo Lee ),( Jong Seok Ahn ),( Ki Hwan Bae ),( Ick Dong Yoo ) 한국미생물 · 생명공학회 2010 Journal of microbiology and biotechnology Vol.20 No.8
In an ongoing investigation of compounds from natural products that exhibit anti-aging properties, hydroxyhibiscone A (1), a new furanosesquiterpenoid, together with hibiscone D (2), was isolated from the root bark of Hibiscus syriacus. Utilizing UV, IR, NMR, and MS spectroscopic analyses, these chemical structures were revealed. Compounds 1 and 2 were found to posses significant anti-aging properties on the human neutrophil elastase (HNE) assay, exhibiting HNE inhibitory activities with IC50 values of 5.2 and 4.6 μM, respectively.
Ryoo, In-Ja,Park, Hae-Ryong,Choo, Soo-Jin,Hwang, Ji-Hwan,Park, Young-Min,Bae, Ki-Hwan,Shin-Ya, Kazuo,Yoo, Ick-Dong Pharmaceutical Society of Japan 2006 BIOLOGICAL & PHARMACEUTICAL BULLETIN Vol.29 No.4
<P>Glucose deprivation is a fundamental feature of poorly vascularized solid tumors and leads to activation of the molecular chaperone GRP78, which is associated with the unfolded protein response (UPR), a stress-signaling pathway, in tumor cells. We recently isolated an active compound, M126, that inhibits transcription from a GRP78 promoter reporter construct. M126 was identified as valinomycin by various spectroscopic methods. We found that valinomycin prevents UPR-induced protein expression, such as GRP78 and GRP94. The GRPs-inhibitory action of valinomycin severe hypoglycemic and results in selective cell death of the stressed cancer cells. Our findings demonstrate that GRP78 may be an excellent target for the use of cancer chemotherapy in the treatment of solid tumors.</P>
柳京子(Ryoo Kyung ja) 한국일본문화학회 2011 日本文化學報 Vol.0 No.48
言語文化教育を「学」として体系化しかつ自律させることが「言語文化教育学」であるとするならば「言語文化教育学とは何か」というテーマは言語文化教育にかかわるもの一人一人にとって生涯のといであるといえよう。 本研究では、言語文化教育と言語文化教育学関係について「教育実践=研究活動」とする見解を述べた上で、言語文化教育学の新しい方向性とその確立をめぐって、最近の日本文化教育のパラダイムの転換の発想として注目されている言語活動の環境設計論、ラグㆍパロール往還文化論に対する体系的な考察を試みた。こうした考察を経て、新しい言語文化教育学の構想が、人間と人間が関係とを取り結ぶためのコミュニケーション環境をつくるための言語活動環境設計と文化は互いに関係しあうことで動態的で多様なあり方であるというラングㆍパロール往還文化論についての理論的な考察を行い、その実現のための、実践研究を通した教育実践の開示と議論の必要性について述べた。 今後の韓国の日本語教育における言語文化教育の方法改善の上では、本研究に示されている面がとくに重視されなければならないと思われる。 本研究では、研究対象の外におかざるをえなかった、韓国の言語文化教育学の理論の体系化、統合化については、今後の課題としたい。
류청자 ( Ryoo Chung-ja ),김선희 ( Kim Seon-hee ) 한국노인의료복지학회 2016 노인의료복지연구 Vol.8 No.2
The study participants were 12 senior citizens living in Kyungbuk province, chosen through convenience sampling. The data was collected by individual in-depth interview from October to November, 2015. Through analysis of the collected data, it was found that the common property of the consistent-excercise factor was `improved quality of life`. The essential categories were, `maintaining independent life`, `health as a gift`, `life lived together`, `improved self-esteem`, `optimistic attitude in life`, `gratitude towards the country`. The elderly that continued to excercise had an aim to pursue everyday-life successfully, with a strong will to carry on independently without having to depend their golden years on his or her children. And they expressed gratitude for the gym facilities provided by the municipality. They were discovering happiness through the social relations formed while excercising rather than their children who lived far away, expressing hope to lead a healthy and exciting remaining life.
산욕기 수유모의 스트레스, 수면의 질, 배우자 지지, 식이섭취 및 LATCH와 모유성분과의 관계
류청자(Ryoo, Chung Ja),강남미(Kang, Nam Mi) 한국웰니스학회 2021 한국웰니스학회지 Vol.16 No.4
본 연구는 S시 소재 산후조리원에서 산후조리 중인 169명 이행기 수유모의 스트레스, 수면의 질, 배우자 지지 및 식이섭취에 대한 자가응답 설문지 자료와 모유수유사정을 위한 LATCH 점수를 수집하고, 기증모유의 단백질과 지방 성분을 분석하였다. SPSS 20.0을 이용하여 실수와 백분율, 평균과 표준편차, t-test, Pearson’s correlation coefficient 등의 통계검정을 시행하였고, 연구의 주요 분석결과는 다음과 같다. 첫째, 스트레스, 수면의 질과 배우자 지지 및 LATCH 점수는 모유 단백질과 지방 성분 함량에 유의한 영향을 미치지 않았다. 둘째, 수유모의 식이섭취는 모유지방과 유의한 상관관계가 나타났다. 본 연구결과를 바탕으로 모유성분의 질적 향상을 위한 식이섭취를 포함한 산전 · 산후 간호중재 개발의 근거자료로 활용할 수 있다. This study is a descriptive research and analysis study to identify the components of breast milk and the emotional and lifestyle factors of nursing mothers during the postpartum period, and to use them as basic data for nursing interventions such as breastfeeding education for mothers during the postpartum period by identifying the relationship between them. Self-response questionnaire data on stress, sleep quality, spousal support, and dietary intake of the final 169 nursing mothers in the transition period who were at postpartum care centers in S city, and LATCH scores for breastfeeding assessment were collected, and protein and fat contents of donated breast milk were analyzed. Statistical tests were performed using SPSS 20.0. The results of this study are as follows. First, stress, sleep quality, spousal support, and LATCH score did not significantly affect the protein and fat content of breast milk. Second, dietary intake of nursing mothers was correlated with breast milk fat(r=-.172, p=.026). As a result of this study, negative emotions induced by stress or poor sleep quality of mothers during the postpartum period did not affect the protein and fat components of breast milk, so it can be used as data for psychological nursing interventions before and after childbirth, such as breastfeeding promotion education. Since dietary intake had an effect on the components of breast milk, it can be used as an intervention data for dietary education of nursing mothers with additional research.