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RISS 인기검색어
- 검색키워드
- 저자 : ( Hossein Goudarzi ) (검색결과 4 건)
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Goudarzi, Mehdi,Seyedjavadi, Sima Sadat,Fazeli, Maryam,Roshani, Maryam,Azad, Mehdi,Heidary, Mohsen,Navidinia, Masoumeh,Goudarzi, Hossein Asian Pacific Journal of Cancer Prevention 2016 Asian Pacific journal of cancer prevention Vol.17 No.7
Helicobacter pylori as the second most common cause of gastric cancer in the world infects approximately half of the developed countries population and 80% of the population living in developing countries. Integrons as genetic reservoirs play major roles in dissemination of antimicrobial resistance genes. To the best of our knowledge, this is the first study to report carriage of class 1 and 2 integrons and associated gene cassettes in H. pylori isolates from Iran. This cross-sectional study was conducted in Tehran among 110 patients with H. pylori infection. Antimicrobial susceptibility testing (AST) for H. pylori strains were assessed by the micro broth dilution method. Class 1 and 2 integrons were detected using PCR. In order to determine gene cassettes, amplified fragments were subjected to DNA sequencing of both amplicon strands. The prevalence of resistance to clarithromycin, metronidazole, clarithromycin, tetracycline, amoxicillin, rifampin, and levofloxacin were 68.2% (n=75), 25.5% (n=28), 24.5% (n=27), 19.1% (n=21), 18.2% (n=20) and 16.4% (n=18), respectively. Frequency of multidrug resistance among H. pylori isolates was 12.7%. Class 2 integron was detected in 50 (45.5%) and class 1 integron in 10 (9.1%) H. pylori isolates. The most predominant gene cassette arrays in class 2 integron-bearing H. pylori were included sat-era-aadA1, dfrA1-sat2-aadA1, blaoxa2 and, aadB whereas common gene cassette arrays in class 1 integron were aadB-aadA1-cmlA6, aacA4, blaoxa2, and catB3. The high frequency of class 2 integron and multidrug resistance in the present study should be considered as a warning for clinicians that continuous surveillance is necessary to prevent the further spread of resistant isolates.
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Goudarzi, Hossein,Seyedjavadi, Sima Sadat,Fazeli, Maryam,Azad, Mehdi,Goudarzi, Mehdi Asian Pacific Journal of Cancer Prevention 2015 Asian Pacific journal of cancer prevention Vol.16 No.13
Helicobacter pylori (H. pylori) infection as a serious problem in both adults and children can induce chronic gastritis, peptic ulcer disease (PUD), and possibly gastric cancer. The aim of the current study was to survey antibiotic resistance and also to determine influence of PPAR$\gamma$ polymorphism in patients with H. pylori infection. During an 11-month-period, 98 H. pylori isolates were collected from 104 biopsy specimens. In vitro susceptibility of H. pylori isolates to 4 antimicrobial agents metronidazole, clarithromycin, amoxicillin and tetracycline were assessed by quantitative method according to European Committee on Antimicrobial Susceptibility Testing (EUCAST) guideline. PPAR$\gamma$ polymorphism was determined using polymerase chain reaction-restriction fragment length polymorphism assay. The frequency of H. pylori infection in our study was 94.2%. In vitro susceptibility data showed that highest level of resistance was related to metronidazole (66.3%), and the majority of H. pylori isolates were highly susceptible to amoxicillin and tetracycline (94.9% and 96.9%, respectively). Genotypic frequencies were 25.5% for CC (Pro12Pro), 40.8% for GC (Pro12Ala) and 33.7% for GG (Ala12Ala). In our study, CG genotype had highest distributions among infected patients with H. pylori. The study suggests that the PPAR-$\gamma$ Pro12Ala polymorphism could be evaluated as a potential genetic marker for susceptibility to gastric cancer in the presence of H. pylori infection.
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Arash Asfaram,Mehrorang Ghaedi,Mohammad Hossein Ahmadi Azqhandi,Alireza Goudarzi,Shaaker Hajati 한국공업화학회 2017 Journal of Industrial and Engineering Chemistry Vol.54 No.-
Response surface methodology (RSM), Artificial Neural Network (ANN) and Radial Basis Function Neural Network (RBFNN) were applied to model and predict the efficiency of two carcinogenic dyes (Methylene blue (MB) and Malachite green (MG)) adsorption onto Mn@ CuS/ZnS nanocomposite-loaded activated carbon (Mn@ CuS/ZnS-NC-AC) as a novel adsorbent. The properties of Mn@ CuS/ZnS-NC-AC were identified by XRD; FE-SEM and EDS. The parameters such as pH, Mn@ CuS/ZnS-NC-AC mass, sonication time, MB concentration and MG concentration involved in the adsorption process were set within the ranges 4.0–8.0, 0.010–0.030 g, 1–5 min, 5–25 mg L1 and 5–25 mg L1, respectively. The applicability of the RBFNN, ANN and RSM models for the description of experimental data was examined using four statistical criteria (coefficient of determination (R2), root mean square error (RMSE), mean absolute error (MAE) and absolute average deviation (AAD)). Compared to RSM, the RBFNN and ANN exhibited better performance for modeling the process of both dyes adsorption. The significant factors were evaluated followed by the optimization of the process. The adsorption of MB and MG was found to be mostly affected by the concentration of MB and MG dyes. The equilibrium adsorption data were analyzed by Langmuir, Freundlich, Temkin and Dubinin–Radushkevich isotherm models. The best fit to the data was obtained by applying the Langmuir model. Meanwhile, the maximum adsorption capacity for MB and MG was estimated to be 126.42 and 115.08 mg g1, respectively.
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( Mahdi Shadnoush ),( Rahebeh Shaker Hosseini ),( Ahad Khalilnezhad ),( Lida Navai ),( Hossein Goudarzi ),( Maryam Vaezjalali ) 대한소화기학회 2015 대한소화기학회지 Vol.65 No.4
Background/Aims: Several clinical trials have revealed various advantages for probiotics in inflammatory bowel disease (IBD). The aim of this study was to further investigate the effects of probiotic yogurt consumption on gut microbiota in patients with this disease. Methods: A total of 305 participants were divided into three groups; group A (IBD patients receiving probiotic yogurt; n=105), group B (IBD patients receiving placebo; n=105), and control group (healthy individuals receiving probiotic yogurt; n=95). Stool samples were collected both before and after 8 weeks of intervention; and population of Lactobacillus, Bifidobacterium and Bacteroides in the stool specimens was measured by Taqman real-time PCR method. Results: By the end of the intervention, no significant variations in the mean weight and body mass index were observed between three groups (p>0.05). However, the mean numbers of Lactobacillus, Bifidobacterium, and Bacteroides in group A were significantly increased compared to group B (p<0.001, p<0.001, and p<0.01, respectively). There were also significant differences in the mean numbers of either of three bacteria between group A and the healthy control group; however, these differences between two groups were observed both at baseline and the end of the intervention. Conclusions: Consumption of probiotic yogurt by patients with IBD may help to improve intestinal function by increasing the number of probiotic bacteria in the intestine and colon. However, many more studies are required in order to prove the concept. (Korean J Gastroenterol 2015;65:215-221)
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