http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
( Hea Yon Lee ),( In Kyoung Kim ),( Hye In Lee ),( Hwa Young Lee ),( Hye Seon Kang ),( Chang Dong Yeo ),( Hyun Hui Kang ),( Hwa Sik Moon ),( Sang Haak Lee ) 대한내과학회 2018 The Korean Journal of Internal Medicine Vol.33 No.3
Background/Aims: We explored the effects of intermittent normobaric hyperoxia alone or combined with chemotherapy on the growth, general morphology, oxidative stress, and apoptosis of benzo[a]pyrene (B[a]P)-induced lung tumors in mice. Methods: Female A/J mice were given a single dose of B[a]P and randomized into four groups: control, carboplatin (50 mg/kg intraperitoneally), hyperoxia (95% fraction of inspired oxygen), and carboplatin and hyperoxia. Normobaric hyperoxia (95%) was applied for 3 hours each day from weeks 21 to 28. Tumor load was determined as the average total tumor numbers and volumes. Several markers of oxidative stress and apoptosis were evaluated. Results: Intermittent normobaric hyperoxia combined with chemotherapy reduced the tumor number by 59% and the load by 72% compared with the control B[a]P group. Intermittent normobaric hyperoxia, either alone or combined with chemotherapy, decreased the levels of superoxide dismutase and glutathione and increased the levels of catalase and 8-hydroxydeoxyguanosine. The Bax/Bcl- 2 mRNA ratio, caspase 3 level, and number of transferase-mediated dUTP nick end-labeling positive cells increased following treatment with hyperoxia with or without chemotherapy. Conclusions: Intermittent normobaric hyperoxia was found to be tumoricidal and thus may serve as an adjuvant therapy for lung cancer. Oxidative stress and its effects on DNA are increased following exposure to hyperoxia and even more with chemotherapy, and this may lead to apoptosis of lung tumors.
( Hea Yon Lee ),( Hye Seon Kang ),( Hwa Young Lee ),( Chin Kook Rhee ),( Sook Young Lee ),( Seok Chan Kim ),( Seung Joon Kim ),( Yeon Joon Park ),( Young Kyoon Kim ),( Ji Young Kang ) 대한내과학회 2017 The Korean Journal of Internal Medicine Vol.32 No.3
Background/Aims: Pneumocystis jirovecii polymerase chain reaction (PCR) can be helpful in diagnosing Pneumocystis pneumonia (PCP); however it has limitations. We evaluated the prevalence of positive P. jirovecii PCR from non-human immunodeficiency virus (HIV) immunocompromised patients and tried to determine the risk of PCP development. Methods: Between May 2009 and September 2012, P. jirovecii PCR was performed in bronchoscopic specimens from 1,231 adult non-HIV immunocompromised patients suspected of respiratory infection. Only 169 patients (13.7%) who were tested positive for P. jirovecii PCR were enrolled. Retrospective chart review was performed. PCP was defined in patients with positive P. jirovecii PCR who were treated for PCP based on the clinical decision. Results: From 169 P. jirovecii PCR-positive patients, 90 patients were in the PCP group (53.3%) and 79 patients were in the non-PCP group (46.7%). In the PCP group, 38% of patients expired or aggravated after therapy, whereas the majority of patients (84%) in the non-PCP group recovered without treatment for PCP. Independent risk factors for PCP by binary logistic regression analysis were underlying conditions- hematological malignancies, solid tumors or solid organ transplantation, dyspnea, age < 60 years, and albumin < 2.9 g/dL. Conclusions: This study suggests that not all P. jirovecii PCR-positive patients need to be treated for PCP. Among P. jirovecii PCR-positive patients, those who are less than 60 years old, with hematological malignancies, solid tumors or solid organ transplantation, low albumin, and with symptoms of dyspnea, the possibility of PCP might be higher. Treatment should also be selected to these patients.
( Hea Yon Lee ),( Hwa Young Lee ),( Ji Young Kang ),( Seung Joon Kim ),( Seok Chan Kim ),( Sook Young Lee ),( Young Kyoon Kim ),( Chin Kook Rhee ) 대한내과학회 2014 대한내과학회 추계학술대회 Vol.2014 No.1
Background: In clinical practice, some patients with asthma show incompletely reversible air ow obstruction, resembling COPD. The aim of this study was to analyze the difference in acute exacerbation between asthma patients and overlap phenotype of asthma and COPD. Methods: A total of 256 patients, over the age of 40 or more with a diagnosis of asthma based on either 1) positive response to bronchodilator: >200 ml FEV1 and >12% baseline or 2) positive methacholine or mannitol provocation test were enrolled. Among the asthma patients, we defi ned the overlap group with incompletely reversible air ow obstruction (postbronchodilator FEV1/FVC < 70) at the initial time of admission and continuing air ow obstruction after at least 3 months follow up. We evaluated the difference in acute exacerbation between the two groups. We defi ned acute exacerbation into 4 categories; 1) admission, 2) emergency room visit, 3) antibiotics therapy or 4) steroid therapy. Results: The study population was divided into two groups: asthma only (62%, n = 159, postbronchodilator FEV1/FVC > 70) and overlap group (38%, n = 97, postbronchodilator FEV1/FVC < 70). The overlap group was older, had more males and a higher percentage of current or ex-smokers than the asthma only group. Signifi cantly lower FEV1 and higher TLC, FRC and RV was observed in the overlap group. However there was no difference in acute exacerbations in all four categories between the two groups. Conclusions: Our results showed that the overlap phenotype were older, male asthmatic patients who have a higher lifetime smoking intensity and generally worse lung function. However there was no difference in the percentage of acute exacerbations in both groups. Further studies are needed.
Barotrauma after Manual Ventilation in a Patient with Life-Threatening Massive Hemoptysis
Hea Yon Lee,Yu Young Joo,Young Seung Oh,Yoo Rim Seo,Hyon Soo Joo,Seok Chan Kim,Chin Kook Rhee 대한중환자의학회 2015 Acute and Critical Care Vol.30 No.4
A 36-year-old female patient with aplastic anemia developed massive hemoptysis and was placed on ventilator support. However, airway obstruction by blood clots triggered desaturation and ventilator malfunction. Manual ventilation was initiated to improve oxygenation, and emergency flexible bronchoscopy was performed to clear the airway. Nevertheless, the patient developed extensive subcutaneous emphysema, pneumothorax, and pneumomediastinum.
Lee, Hea-Yon,Kim, Jin-Jin,Ko, Eun-Sil,Kim, Sei-Won,Lee, Sang-Haak,Kang, Hyeon-Hui,Park, Chan-Kwon,Min, Ki-Ouk,Lee, Bae-Young,Moon, Hwa-Sik,Kang, Ji-Young The Korean Academy of Tuberculosis and Respiratory 2010 Tuberculosis and Respiratory Diseases Vol.69 No.4
We report the case of a 68-year-old man with a stromal tumor of uncertain malignant potential (STUMP), which had metastasized to the lung. The patient complained of an enlarged mass in the anterior chest. Chest computed tomography (CT) showed a sternal abscess with multiple nodules in both lungs. A thoracoscopic lung biopsy of the nodules and incision/drainage of the sternal mass were performed simultaneously. CT of the pelvis revealed an enlarged prostate with irregular cystic lesions in the pelvis. Prostate biopsy was done and demonstrated hypercellular stroma with minimal cytological atypia, a distinct pattern of STUMP. The sternal abscess proved to be tuberculosis and the lung lesion was consistent with STUMP, which had spread from the prostate. However, to our knowledge, the tuberculous abscess might not be assoicated with STUMP in the lung. The patient refused surgical prostatectomy and was discharged with anti-tuberculosis medication. On one-year follow up, the patient had no evidence of disease progression.
Frailty and Comprehensive Geriatric Assessment
Hea Yon Lee,Eunju Lee,Il-Young Jang 대한의학회 2020 Journal of Korean medical science Vol.35 No.3
Frailty is defined as a reduced physiologic reserve vulnerable to external stressors. For older individuals, frailty plays a decisive role in increasing adverse health outcomes in most clinical situations. Many tools or criteria have been introduced to define frailty in recent years, and the definition of frailty has gradually converged into several consensuses. Frail older adults often have multi-domain risk factors in terms of physical, psychological, and social health. Comprehensive geriatric assessment (CGA) is the process of identifying and quantifying frailty by examining various risky domains and body functions, which is the basis for geriatric medicine and research. CGA provides physicians with information on the reversible area of frailty and the leading cause of deterioration in frail older adults. Therefore frailty assessment based on understanding CGA and its relationship with frailty, can help establish treatment strategies and intervention in frail older adults. This review article summarizes the recent consensus and evidence of frailty and CGA.
Clinical significance of serum vascular endothelial growth factor in young male asthma patients
( Hea Yon Lee ),( Kyung Hoon Min ),( Sang Min Lee ),( Ji Eun Lee ),( Chin Kook Rhee ) 대한내과학회 2017 The Korean Journal of Internal Medicine Vol.32 No.2
Background/Aims: Vascular endothelial growth factor (VEGF) is an important mediator of angiogenesis. However, little is known about the potential use of serum levels of VEGF as a biomarker for asthma. We investigated the differences in VEGF levels among normal controls, stable asthma patients, and those with exacerbation of acute asthma. All subjects were young males. Methods: We measured VEGF levels in each patient group, and examined any serial changes in those with acute exacerbation. Results: VEGF levels were significantly higher in stable asthmatic patients and even more so in acute asthmatic patients, compared to healthy controls. However, there was no correlation between VEGF levels and forced expiratory volume in 1 second in patients with stable asthma. In addition, there were no correlations between VEGF levels and asthma control test scores. In patients with acute exacerbation, VEGF levels significantly increased during the acute period; their levels decreased gradually at 7 and 14 days after treatment. Conclusions: Compared to normal control patients, the serum levels of VEGF were elevated in stable asthma patients and even more elevated in patients with acute exacerbation. However, the role of VEGF as a biomarker in stable asthma is limited. In patients with acute exacerbation, VEGF levels were associated with clinical improvements.
( Hea Yon Lee ),( Hwa Young Lee ),( Jung Hur ),( Hye Seon Kang ),( Joon Young Choi ),( Chin Kook Rhee ),( Ji Young Kang ),( Young Kyoon Kim ),( Sook Young Lee ) 대한내과학회 2020 The Korean Journal of Internal Medicine Vol.35 No.3
Background/Aims: Thymic stromal lymphopoietin (TSLP) is an epithelial cell-derived cytokine that plays a key role in Th2-mediated inflammation, both directly by promoting the proliferation of naive CD4 Th2 cells, and indirectly by activating dendritic cells (DCs). TSLP-activated DCs induce the expansion of chemoattractant receptor homologous molecule expressed on Th2 (CRTH2)+ CD4+ Th2 memory cells, which undergo a Th2 response and express prostaglandin D2 (PGD2) synthase. CRTH2, a PGD2 receptor, is a selective Th2-cell surface marker. We investigated the effects of an anti-TSLP antibody (Ab) and a CRTH2 antagonist, as well as their mechanisms of action, in a mouse model of acute asthma. Methods: BALB/c mice were sensitized and challenged with ovalbumin. We then evaluated the effects of the administration of an anti-TSLP Ab either alone or together with a CRTH2 antagonist on cell counts, Th2 cytokine levels in bronchoalveolar fluid, and the levels of epithelium-derived cytokines such as TSLP, interleukin (IL) 33, and IL-25 in lung homogenates, as well as airway hyper-responsiveness (AHR). Results: Anti-TSLP Ab and the CRTH2 antagonist significantly attenuated eosinophilic airway inflammation, AHR, and the expression of Th2 cytokines. The expression of GATA-3 and the levels of IL-33 and IL-25 in lung tissues were affected by the combined anti-TSLP and CRTH2 antagonist treatment. Conclusions: These results suggest that the dual blockade of TSLP and CRTH2 may serve as an effective treatment target for eosinophilic asthma.