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The involvement of Parkin-dependent mitophagy in the anti-cancer activity of Ginsenoside
Xin Sun,Yeting Hong,Yuhan Shu,Caixia Wu,Guiqin Ye,Hanxiao Chen,Hongying Zhou,Ruilan Gao,Jianbin Zhang 고려인삼학회 2022 Journal of Ginseng Research Vol.46 No.2
Colon cancer, the third most frequent occurred cancer, has high mortality and extremely poor prognosis. Ginsenoside, the active components of traditional Chinese herbal medicine Panax ginseng, exerts antitumor effect in various cancers, including colon cancer. However, the detailed molecular mechanism of Ginsenoside in the tumor suppression have not been fully elucidated. Here, we chose the representative ginsenoside Rg3 and reported for the first time that Rg3 induces mitophagy in human colon cancer cells, which is responsible for its anticancer effect. Rg3 treatment leads to mitochondria damage and the formation of mitophagosome; when autophagy is inhibited, the clearance of damaged mitochondria can be reversed. Next, our results showed that Rg3 treatment activates the PINK1-Parkin signaling pathway and recruits Parkin and ubiquitin proteins to mitochondria to induce mitophagy. GO analysis of Parkin targets showed that Parkin interacts with a large number of mitochondrial proteins and regulates the molecular function of mitochondria. The cellular energy metabolism enzyme GAPDH is validated as a novel substrate of Parkin, which is ubiquitinated by Parkin. Moreover, GAPDH participates in the Rg3-induced mitophagy and regulates the translocation of Parkin to mitochondria. Functionally, Rg3 exerts the inhibitory effect through regulating the nonglycolytic activity of GAPDH, which could be associated with the cellular oxidative stress. Thus, our results revealed GAPDH ubiquitination by Parkin as a crucial mechanism for mitophagy induction that contributes to the tumor-suppressive function of ginsenoside, which could be a novel treatment strategy for colon cancer.
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Shixin Song,Hanxiao Lv,Yuanjing Bi,Shulin Sun,HuiXuan Zhang 한국고분자학회 2017 Macromolecular Research Vol.25 No.5
Colloid silica nanoparticles were hydrophobic modified by γ-methacryloxypropyl trimethoxysilane (MPS) for the encapsulation into polymer. The alkoxysilane- functionalized core-shell latexes were successfully synthesized via miniemulsion copolymerization of the butyl acrylate, styrene with MPS as the functional monomer in the presence of the modified silica. When these latexes dried at room-temperature, the post-cross-linking occurred due to the alkoxysilane groups on the particle surface and lead to the formation of the films. The morphology of the nanocomposite latexes and the mechanical properties, thermal properties, fire-resistant, optical properties and micro-structure of the resulted films were characterized and discussed. Scanning electron microscope result showed most of the nanoparticles dispersed homogeneously in the polymer matrix when the content of MPS-silica was 10%. However, when the content of MPS-silica nanoparticles was beyond 10%, the aggregation of the nanoparticles became obvious. The tensile test showed that the stress at break increased a lot with the increase of silica content. The thermal and fire-resistant behaviors of the nanocomposite films were improved greatly by the incorporation of silica particles. The optical test showed that the hybrid film was comparable to the pure polymer film at around 84% transmittance.
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( Yahui Gong ),( Tiyuan Li ),( Shiyu Li ),( Zhenyou Jiang ),( Yan Yang ),( Junli Huang ),( Zhaobing Liu ),( Hanxiao Sun ) 한국미생물 · 생명공학회 2016 Journal of microbiology and biotechnology Vol.26 No.6
Lactobacilli are universally recognized as probiotics that are widely used in the adjuvant treatment of inflammatory diseases, such as vaginitis and enteritis. With the overuse of antibiotics in recent years, the lactobacilli in the human body are killed, which could disrupt the microecological balance in the human body and affect health adversely. In this work, cephalosporin-resistant Lactobacillus casei RL20 was obtained successfully from the feces of healthy volunteers, which possessed a stable genetic set. However, the shortage of lactic acid (72.0 g/l at 48 h) by fermentation did not meet the requirement for its use in medicine. To increase the production of lactic acid, the functional genes pfk and glk were introduced into the wild strain. A yield of 144.2 g/l lactic acid was obtained in the transgenic L. casei RL20-2 after fermentation for 48 h in 1 L of basic fermentation medium with an initial glucose concentration of 100 g/l and increasing antibacterial activity. These data suggested that L. casei RL20-2 that exhibited a high yield of lactic acid may be a potential probiotic to inhibit the spread of bacterial infectious diseases and may be used for vaginitis therapy.
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