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Quo Vadis, barrier researcher?
( G. K. Menon ) 한국피부장벽학회 2020 한국피부장벽학회지 Vol.22 No.2
After about 40 years of Barrier research, and more than 20 GRCs on skin Barrier, it is worth asking if we are at a saturation point; a kind of midlife crisis, on where to head next. Are we through most available models, exhausted the potential use of TEM, covered most of the “Omics” related to the permeability barrier and nearly done with developing newer transdermal delivery devices? As a retired (but not yet tired) barrier researcher lacking access to labs and instruments, I often review images and data from the past and try to see things in a new light. Essentially, observations and speculations are what fostered science in generations even before my time. Albert Szent-Gyorgyi is credited with stating that “Research is to see what everyone else has seen, and to think what no one else thought”. We are all capable of doing it; if willing to take a break from rushing to ‘generate data’ and question the accepted wisdom. In a short presentation, I will try to apply this to Barrier Research, even at the risk of inviting ridicule; re-evaluating some of the familiar morphological images (TEM) for speculative thinking. I will focus on the Lamellar body secretion, hydration effects on SC, and a couple of models / diseases with greatly altered dermal functions. While I do not have suggestions on resolving any of these, I do hope that my very creative young friends in the Asian Barrier Research Group would develop methods to do so, and prove or disapprove these speculations.
K. B. Padmakumar,B. R. Smitha,Lathika Cicily Thomas,C. L. Fanimol,G. SreeRenjima,N. R. Menon,V. N. Sanjeevan 한국해양과학기술원 2010 Ocean science journal Vol.45 No.3
This study presents in situ evidence for the blooms of Trichodesmium erythraeum observed in the shelf waters of the South Eastern Arabian Sea (SEAS) during the onset of the southwest monsoon in June 2009. Evidence showed that water surface discoloration was caused by the accumulation of T. erythraeum, and that the water column contained a colony of T. thiebautii. The surface water color in the bloom region varied from pale brown to pinkish red. Pale brown indicated healthy algae at the peak of its photosynthetic activity, while pinkish red indicated the presence of photosynthetically less active filaments. Zooplankton abundance, especially copepodites, in the bloom area substantiated the theory that Trichodesmium filaments are excellent epiphytes to which the copepodites cling. The bloom area was very fertile with copious quantities of dissolved oxygen (6.85 ml L-1), PO4-P (0.108 μmol L-1) and SiO4 (1.29 μmol L-1). Lower NO3-N (0.028 μmol L-1) values in the bloom area did not appear to affect Trichodesmium growth from molecular nitrogen fixation. However, lower NO3-N values altered the normal phytoplankton composition of this area.
Sushanth Rao Aroor,Kaiz S. Asif,Jennifer Potter-Vig,Arun Sharma,Bijoy K. Menon,Violiza Inoa,Cynthia B. Zevallos,Jose G. Romano,Santiago Ortega-Gutierrez,Larry B. Goldstein,Dileep R. Yavagal 대한뇌졸중학회 2022 Journal of stroke Vol.24 No.1
Mechanical thrombectomy (MT) is the most effective treatment for selected patients with an acute ischemic stroke due to emergent large vessel occlusions (LVOs). There is an urgent need to identify and address challenges in access to MT to maximize the numbers of patients who can benefit from this treatment. Barriers in access to MT include delays in evaluation and accurate diagnosis of LVO leading to inappropriate triage, logistical delays related to availability of facilities and trained interventionalists, and financial hurdles that affect treatment reimbursement. Collection of regional data related to these barriers is critical to better understand current access gaps and a measurable access score to thrombectomy could be useful to plan local public health intervention.