Data Gap in Sacral Neuromodulation Documentation: Call to Improve Documentation Protocols

Christopher M. Hornung,Ranveer Vasdev,Kate A. Hanson,Rachael Gotlieb,Cynthia S. Fok,John Fischer,Nissrine A. Nakib,Dwight E. Nelson 대한배뇨장애요실금학회 2022 International Neurourology Journal Vol.26 No.3

Purpose: We quantified patient record documentation of sacral neuromodulation (SNM) threshold testing and programming parameters at our institution to identify opportunities to improve therapy outcomes and future SNM technologies. Methods: A retrospective review was conducted using 127 records from 40 SNM patients. Records were screened for SNM documentation including qualitative and quantitative data. The qualitative covered indirect references to threshold testing and the quantitative included efficacy descriptions and device programming used by the patient. Findings were categorized by visit type: percutaneous nerve evaluation (PNE), stage 1 (S1), permanent lead implantation, stage 2 (S2) permanent impulse generator implantation, device-related follow-up, or surgical removal. Results: Documentation of threshold testing was more complete during initial implant visits (PNE and S1), less complete for S2 visits, and infrequent for follow-up clinical visits. Surgical motor thresholds were most often referred to using only qualitative comments such as “good response” (88%, 100% for PNE, S1) and less commonly included quantitative values (68%, 84%), locations of response (84%, 83%) or specific contacts used for testing (0%). S2 motor thresholds were less well documented with qualitative, quantitative, and anatomical location outcomes at 70%, 48%, and 36% respectively. Surgical notes did not include specific stimulation parameters or contacts used for tests. Postoperative sensory tests were often only qualitative (80%, 67% for PNE, S1) with quantitative values documented much less frequently (39%, 9%) and typically lacked sensory locations or electrode-specific results. For follow-up visits, <10% included quantitative sensory test outcomes. Few records (<7%) included device program settings recommended for therapy delivery and none included therapy-use logs. Conclusions: While evidence suggests contact and parameter-specific programming can improve SNM therapy outcomes, there is a major gap in the documentation of this data. More detailed testing and documentation could improve therapeutic options for parameter titration and provide design inputs for future technologies.

Conformation-Specific Spectroscopy of Asparagine-Containing Peptides: Influence of Single and Adjacent Asn Residues on Inherent Conformational Preferences

Blodgett, Karl N.,Fischer, Joshua L.,Lee, Jaeyeon,Choi, Soo Hyuk,Zwier, Timothy S. American Chemical Society 2018 The Journal of physical chemistry A Vol.122 No.44

<P>The infrared and ultraviolet spectra of a series of capped asparagine-containing peptides, Ac-Asn-NHBn, Ac-Ala-Asn-NHBn, and Ac-Asn-Asn-NHBn, have been recorded under jet-cooled conditions in the gas phase in order to probe the influence of the Asn residue, with its −CH<SUB>2</SUB>-C(═O)-NH<SUB>2</SUB> side chain, on the local conformational preferences of a peptide backbone. The double-resonance methods of resonant ion-dip infrared (RIDIR) spectroscopy and infrared-ultraviolet hole-burning (IR-UV HB) spectroscopy were used to record single-conformation spectra in the infrared and ultraviolet, respectively, free from interference from other conformations present in the molecular beam. Ac-Asn-NHBn spreads its population over two conformations, both of which are stabilized by a pair of H-bonds that form a bridge between the Asn carboxamide group and the NH and C═O groups on the peptide backbone. In one the peptide backbone engages in a 7-membered H-bonded ring (labeled C7<SUB>eq</SUB>), thereby forming an inverse γ-turn, stabilized by a C6/C7 Asn bridge. In the other the Asn carboxamide group forms a C8/C7 H-bonded bridge with the carboxamide group facing in the opposite direction across an extended peptide backbone involving a C5 interaction. Both Ac-Ala-Asn-NHBn and Ac-Asn-Asn-NHBn are found exclusively in a single conformation in which the peptide backbone engages in a type I β-turn with its C10 H-bond. The Asn residue(s) stabilize this β-turn via C6 H-bond(s) between the carboxamide C═O group and the same residue’s amide NH. These structures are closely analogous to the corresponding structures in Gln-containing peptides studied previously [Walsh, P. S. et al. <I>PCCP</I><B>2016</B>, <I>18</I>, 11306-11322; Walsh, P. S. et al. <I>Angew. Chem. Int. Ed.</I><B>2016</B>, <I>55</I>, 14618-14622], indicating that the Asn and Gln side chains can each configure so as to stabilize the same backbone conformations. Spectroscopic and computational evidence suggest that glutamine is more predisposed than asparagine to β-turn formation via unusually strong side-chain-backbone hydrogen-bond formation. Further spectral and structural similarities and differences due to the side-chain length difference of these similar amino acids are presented and discussed.</P> [FIG OMISSION]</BR>

MANAGING SUCCESSIVE COBRANDING ALLIANCES IN FASHION FIRMS

Marie-Agnès Parmentier,Eileen Fischer 글로벌지식마케팅경영학회 2015 Global Fashion Management Conference Vol.2015 No.06

“What makes a label sell: its name or the person behind it?” (The Guardian, 3-3-2000) It seems like fashion houses have spent the last decade playing the musical chairs game with their fashion designers (Socha, 2012). At Saint Laurent Paris, for instance, Hedi Slimane, who was the label’s men’s creative director from 1997 to 2000, came back as creative director in 2012 to replace Stefano Pilati (2004-2012) who, himself, had replaced Tom Ford (2000-2004) previously. Meanwhile, at Louis Vuitton, Nicolas Ghesquière left Balenciaga to fill the shoes of Marc Jacobs who had been creative director for the label since the late 1990s (1997-2013). And at Dior, Raf Simons took over from Bill Gaytten (2011-2012) who had discretely held the ship after the abrupt departure of John Galliano (1996-2011). The phenomenon of a brand having to replace a key persona with whom it is cobranded is far from rare: sports team regularly draft new athletes, television screenwriters kill beloved characters because actors are leaving their shows, and political parties must replace departing leaders. In these contexts, as in fashion firms, maintaining brand equity across successive cobranding alliances with key personae is a challenging brand management issue. In this research project, we aim to further our understanding of how fashion brands can maintain equity by examining how they manage ongoing cobranding between the house and the designer, especially given the challenges faced by the succession of designers – or game of musical chairs - most houses face. The research questions guiding this effort are as follows: 1) Why do fashion houses cobrand with key personas? 2) What challenges are associated with cobranding with key personas? and 3) What strategies are enacted to address these challenges? To investigate these questions, we have examined the ways that some of the most successful fashion houses manage their brand equity through the dynamics of cobranding. We illustrate our findings with the case of Saint Laurent Paris, a fashion house established in 1968 by Algerian-born French designer Yves Saint Laurent. In this abstract, we first review some key literature on cobranding, then discuss our methodology. We conclude by presenting our preliminary findings. Theoretical Perspectives on Cobranding A generic definition of cobranding refers to it as an alliance “in which two or more brands are presented to the public” (Newmeyer, Venkatesh and Chatterjee 2014). In practice, conceptualizations of cobranding vary. One that is common entails “ingredient branding” in which a key ingredient of one brand is some other brand, such as an Intel chip inside a Dell computer (e.g., Desai and Keller 2002). Another common conceptualization refers to two parent brands launching a new product, as when “two leading fashion houses…join forces to create a new line of clothing” (Monga and Lau-Gesk 2007, 391). Recent work has also acknowledged that cobranding can take place between people and brands. For example Wilcox and Carroll (2008) discuss celebrity cobranding, wherein a celebrity cobrands with a product brand. And in the organizational literature, the fact that a CEO’s personal brand is intermingled with that of the company that person manages has been well recognized (e.g., Graffin, Carpenter, and Boivie 2011). Our conceptualization of fashion designers as cobranded with the houses that employ them is consistent with such research, in that it considers a type of cobranding in which an employee who is a key persona in a company, and that company’s product offerings, are together presented to the public. A frequent assumption in much cobranding research is that it takes places “between two successful brands” (Monga and Lau-Gesk 2007, 389); however, in practice, it is possible for the two brands in an alliance to vary in the extent to which they are already well known and successful (Cunha, Forehand and Angle 2015). Further, cobranding arrangements can vary in terms of the level of integration; in some instances, cobranding might entail mere co-location, whereas in others, the brand partnership may mean that the features of the each brand are tightly integrated and difficult to decouple (Newmeyer et al. 2014). Relatedly, cobranding may vary in terms of duration, ranging from a promotional cobranding that is intentionally short-lived to enduring cobranding that is intended to persist for years or decades. The focus of past cobranding research has frequently been on exploring how consumers respond to cobrands. However, scholarly attention has also been turned to the strategies that firms use to manage the challenges of cobranding. Our work falls within the latter category. Methodology Data Collection To examine the dynamics of cobranding with a key persona in the fashion context, we collected a combination of archival and observational data from five major fashion houses: Balenciaga, Dior, Gucci, Louis Vuitton, and Saint Laurent Paris. The archival data includes articles drawn from the fashion coverage of the last fifteen years of: The New York Times, The Financial Times, The Guardian, The Wall Street Journal, The Daily Telegraph and Le Monde. Coverage from fashion industry key media references such as Women’s Wear Daily, Style.com and Vogue.com is comprised as well. Using Factiva, Lexis-Nexis, and the fashion houses’ own digital archives, we searched and collected articles that pertained to the disintegration of the cobranded alliance and integration into of the new cobranded alliance for the fashion houses mentioned above. In our dataset, we also included reviews of promotional materials such as fashion exhibitions (e.g., Müller and Chenoune’s (2010) “Yves Saint Laurent”), and popular culture artifacts such as films (e.g., Lespert’s (2014) “Yves Saint Laurent”). Furthermore, to help us contextualize the branding strategies and practices of the fashion houses, we reviewed documentaries and books published about the fashion industry such as Nicklaus (2012) “Fashion Go Global,” English’s (2007) “A Cultural History of Fashion in the 20th century,” Palomo-Lovinski’s (2010) “The World’s Most influential Fashion Designers,” and Steele and Menkes’ (2012) “Fashion Designers: A-Z.” Finally, our archival dataset was complemented by observational data gathered from visits to the fashion houses’ New York City flagships and department stores’ concessions. Data Analysis Following the conventions of qualitative research (Belk, Fischer and Kozinets 2013), the analysis of our data was an iterative process of interpreting, deriving new questions, searching for and collecting new data, and rejecting, confirming, and refining our emerging interpretation until reaching sufficient interpretive convergence and theoretical saturation. We present a summary of our findings in the next section. Findings Below, we indicate our answers to the three research questions raised in the beginning of this abstract. 1) Why do fashion houses cobrand with key personas? Luxury fashion houses operate in an institutional field where the logic of art and the logic of commerce are intertwined (Scaraboto and Fischer, 2013). While fashion may not be art per se, well-respected figures such as Pierre Bergé, Yves Saint Laurent’s longtime romantic and business partner, consider that it requires an artist to create fashion (Bergé, 2015). Dion and Arnould (2011), in their research on the charismatic aura of contemporary luxury fashion designers, have argued that managing the relationship between a fashion house and its artist, i.e. the designer, is an essential element of successful luxury brand management. In the fashion industry, cobranding efforts between a fashion house and a designer thus appears to be a deeply institutionalized norm from which deviating could be risky. One reason behind this institutionalized norm is that the business of fashion requires constant renewal (e.g., Agogué and Nainville, 2010). The introduction of a new designer within an established house can serve this renewal purpose. Moreover, as celebrity culture seems to pervade every sphere of life, the phenomenon of celebrity designers resonates with broader socio-cultural trends (Agins, 2014; Oeppen and Jamal, 2014), reinforcing the value of a key persona’s vibrant image. 2) What challenges are associated with cobranding with key personas? For a fashion house, at least two challenges are associated with cobranding with a key persona: 1) maintaining brand continuity and 2) protecting the brand from a key persona’s imperfections. The first challenge implies that while the nature of the fashion industry invites brands to constantly refresh their offerings and engage in innovation (Oeppen and Jamal, 2014), fashion houses, like other brands, must also strive to maintain brand continuity in order to preserve their brand equity (Keller, 2000). Maintaining brand continuity while keeping the brand fresh suggests maintaining a clear and differentiated brand positioning while enrolling new brand meanings that can sometimes be contradictory or counterintuitive (e.g., “Gucci's top designer to refashion YSL look,” Finn, 2000). When a fashion house joins forces with a key persona, the aesthetic, style and cut of what the designer creates must somehow blend with the core attributes of the fashion house to create, an overall brand experience that is innovative, yet reminiscent of the house’s signature. The second challenge fashion houses face when cobranding with a key persona is protecting the brand from human imperfections. Among these “imperfections,” the most obvious is the inevitable mortality of key personas. In addition, key personas, by virtue of being human, have other purposes in life than consistently serving the market. Their actions and behaviors may sometimes conflict with, be counterproductive to, and/or undermine their own brand equity development (Parmentier and Fischer, 2012,) and that of their partner in a cobranding alliance (e.g., Béroard and Parmentier, 2014). 3) What strategies are enacted to address these challenges? We identify strategies enacted to disintegrate relationships with designers who are departing and those used to integrate new designers into cobranded relationships with the houses that hire them. Examples of strategies enacted to disintegrate cobranding relationships include “erasing” “denigrating,” and “respectfully acknowledging” the departing designer. Examples of integrating strategies include “legacy linking,” “restricting sphere of influence,” “fostering self promotion,” and “encouraging innovation.” The paper defines these strategies, notes that they are not mutually exclusive but rather may be complementary, offers examples of all strategies drawing on the data collected, and offers preliminary insights on the implications of these strategies.

Tailoring magnetic energies to form dipole skyrmions and skyrmion lattices

Montoya, S. A.,Couture, S.,Chess, J. J.,Lee, J. C. T.,Kent, N.,Henze, D.,Sinha, S. K.,Im, M.-Y.,Kevan, S. D.,Fischer, P.,McMorran, B. J.,Lomakin, V.,Roy, S.,Fullerton, E. E. American Physical Society 2017 Physical Review B Vol.95 No.2

<P>The interesting physics and potential memory technologies resulting from topologically protected spin textures such as skyrmions have prompted efforts to discover new material systems that can host these kinds of magnetic structures. Here, we use the highly tunable magnetic properties of amorphous Fe/Gd multilayer films to explore the magnetic properties that lead to dipole-stabilized skyrmions and skyrmion lattices that form from the competition of dipolar field and exchange energy. Using both real space imaging and reciprocal space scattering techniques, we determined the range of material properties and magnetic fields where skyrmions form. Micromagnetic modeling closely matches our observation of small skyrmion features (similar to 50 to 70 nm) and suggests that these classes of skyrmions have a rich domain structure that is Bloch-like in the center of the film and more Neel-like towards each surface. Our results provide a pathway to engineer the formation and controllability of dipole skyrmion phases in a thin film geometry at different temperatures and magnetic fields.</P>

Resonant properties of dipole skyrmions in amorphous Fe/Gd multilayers

Montoya, S. A.,Couture, S.,Chess, J. J.,Lee, J. C. T.,Kent, N.,Im, M.-Y.,Kevan, S. D.,Fischer, P.,McMorran, B. J.,Roy, S.,Lomakin, V.,Fullerton, E. E. American Physical Society 2017 Physical Review B Vol.95 No.22

<P>The dynamic response of dipole skyrmions in Fe/Gd multilayer films is investigated by ferromagnetic resonance measurements and compared to micromagnetic simulations. We detail thickness-and temperature-dependent studies of the observed modes as well as the effects of magnetic field history on the resonant spectra. Correlation between the modes and the magnetic phase maps constructed from real-space imaging and scattering patterns allows us to conclude that the resonant modes arise from local topological features such as dipole skyrmions but do not depend on the collective response of a close-packed lattice of these chiral textures. Using micromagnetic modeling, we are able to quantitatively reproduce our experimental observations which suggests the existence of localized spin-wave modes that are dependent on the helicity of the dipole skyrmion. We identify four localized spin-wave excitations for the skyrmions that are excited under either in-plane or out-of-plane rf fields. Lastly we show that dipole skyrmions and nonchiral bubble domains exhibit qualitatively different localized spin-wave modes.</P>

Engrailed protects mouse midbrain dopaminergic neurons against mitochondrial complex I insults

Alvarez-Fischer, Daniel,Fuchs, Julia,Castagner, Fran챌ois,Stettler, Olivier,Massiani-Beaudoin, Olivia,Moya, Kenneth L,Bouillot, Colette,Oertel, Wolfgang H,Lomb챔s, Anne,Faigle, Wolfgang,Joshi, Rajiv L,H Nature Publishing Group, a division of Macmillan P 2011 NATURE NEUROSCIENCE Vol.14 No.10

Mice heterozygous for the homeobox gene Engrailed-1 (En1) display progressive loss of mesencephalic dopaminergic (mDA) neurons. We report that exogenous Engrailed-1 and Engrailed-2 (collectively Engrailed) protect mDA neurons from 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP), a mitochondrial complex I toxin used to model Parkinson's disease in animals. Engrailed enhances the translation of nuclearly encoded mRNAs for two key complex I subunits, Ndufs1 and Ndufs3, and increases complex I activity. Accordingly, in vivo protection against MPTP by Engrailed is antagonized by Ndufs1 small interfering RNA. An association between Engrailed and complex I is further confirmed by the reduced expression of Ndufs1 and Ndufs3 in the substantia nigra pars compacta of En1 heterozygous mice. Engrailed also confers in vivo protection against 6-hydroxydopamine and 慣-synuclein-A30P. Finally, the unilateral infusion of Engrailed into the midbrain increases striatal dopamine content, resulting in contralateral amphetamine-induced turning. Therefore, Engrailed is both a survival factor for adult mDA neurons and a regulator of their physiological activity.

해외저술 소개 : 임상 연구: 진단 ; 대장직장암으로부터의 간전이로 인한 간내담관의 확장(초)

( Jhaveri K. S. ),( Halankar J. ),( Aguirre D. ),( Haider M. ),( Lockwood G. ),( Guindi M. ),( Fischer S. ) 대한간암연구회 2010 대한간암학회지 Vol.10 No.-

Conservation and Rewiring of Functional Modules Revealed by an Epistasis Map in Fission Yeast

Roguev, A.,Bandyopadhyay, S.,Zofall, M.,Zhang, K.,Fischer, T.,Collins, S. R.,Qu, H.,Shales, M.,Park, H.-O.,Hayles, J.,Hoe, K.-L.,Kim, D.-U.,Ideker, T.,Grewal, S. I.,Weissman, J. S.,Krogan, N. J. American Association for the Advancement of Scienc 2008 Science Vol.322 No.5900

IPCC AR6 WGI 제4장 주요 내용과 핵심 결과

June-Yi Lee,J. Marotzke,G. Bala,L. Cao,S. Corti,J. P. Dunne,F. Engelbrecht,E. Fischer,J. C. Fyfe,C. Jones,A. Maycock,J. Mutemi,O. Ndiaye,S. Panickal,T. Zhou,Maycock,J. Mutemi,O. Ndiaye,S. Panickal,T. 한국기상학회 2021 한국기상학회 학술대회 논문집 Vol.2021 No.10

The chapter 4 of Working Group I contribution to the IPCC Sixth Assessment Report assesses simulations of future global climate change, spanning time horizons from the near term (2021-2040),mid-term (2041-2060), and long term (2081-2100) out to the year 2300. The chapter assesses physical indicators of global climate change, such as global surface air temperature, global land precipitation, Arctic sea-ice area and global mean sea level. Furthermore, the chapter covers indices and patterns of properties and circulation not only for mean fields but also for modes of variability that have global significance. Changes are assessed relative to both the recent past (1995-2014) and the 1850-1900 approximation to the pre-industrial period. The projections assessed in the chapter are mainly based on a new range of scenarios, the Shared Socio-economic Pathways (SSPs) used in the Coupled Model Intercomparison Project Phase 6 (CMIP6). Additional lines of evidence enter the assessment, especially for change in globally averaged surface air temperature and global mean sea level, while assessment for changes in other quantities is mainly based on CMIP6 results. After section 4.2 on the methodologies used in the assessment, Section 4.3 assesses projected changes inkey global climate indicators throughout the 21<SUP>st</SUP> century. Section4.4. covers near-term climate change and Section 4.5 assesses mid-term andlong-term climate change. Section 4.6 addresses the climate implications of climate policies including patterns of climate change expected for various global warming levels, climate goals, overshoot, and path-dependence, as well as the climate response the climate response to mitigation, Carbon Dioxide Removal, and Solar Radiation Modification. Section 4.7 assesses very long-term changes up to 2300 and climate-change commitment and the potential for irreversibility and abrupt climate change. The chapter concludes with Section4.8 on the potential for low-probability-high-impact changes.

Analysis of the Dosimetry Cross Sections Measurements up to 35 MeV with a ^7Li(p,xn) Quasi-Monoenergetic Neutron Source

S. P. Simakov,U. Fischer,Pavel Bem,V. Burjan,M. Gotz,M. Honusek,V. Kroha,J. Novak,E. Simeckova,R. A. Forrest 한국물리학회 2011 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.59 No.23

To improve the status of the dosimetry reaction data above 20 MeV, the activation cross sections on Bi, Au, Co and Nb have been measured at the NPI/Rez cyclotron facility with a quasi-monoenergetic p-^7Li neutron source. The present work comprises the computational analysis of this experiment. It includes the Monte-Carlo simulation of the experimental set-up with the MCNPX code and relevant cross section data for proton and neutron induced reactions to predict the energy differential neutron flux in the irradiated foils. This approach has been validated against p-Li neutron spectra measured by different techniques. By making use of the modified unfolding code SAND-II, the dosimetry cross sections have been derived from the detected γ-ray activities. This has brought the new experimental results in the neutron energy domain between 18 and 35 MeV with estimated uncertainty at the level of 10%. They were used for validation of the activation (EAF, IEAF, IRDF) and the general purpose (ENDF) cross section files.