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Recognition of Transmembrane Protein 39A as a Tumor-Specific Marker in Brain Tumor
Park, Jisoo,Lee, Hyunji,Tran, Quangdon,Mun, Kisun,Kim, Dohoon,Hong, Youngeun,Kwon, So Hee,Brazil, Derek,Park, Jongsun,Kim, Seon-Hwan Korean Society of ToxicologyKorea Environmental Mu 2017 Toxicological Research Vol.33 No.1
Transmembrane protein 39A (TMEM39A) belongs to the TMEM39 family. TMEM39A gene is a susceptibility locus for multiple sclerosis. In addition, TMEM39A seems to be implicated in systemic lupus erythematosus. However, any possible involvement of TMEM39A in cancer remains largely unknown. In the present report, we provide evidence that TMEM39A may play a role in brain tumors. Western blotting using an anti-TMEM39A antibody indicated that TMEM39A was overexpressed in glioblastoma cell lines, including U87-MG and U251-MG. Deep-sequencing transcriptomic profiling of U87-MG and U251-MG cells revealed that TMEM39A transcripts were upregulated in such cells compared with those of the cerebral cortex. Confocal microscopic analysis of U251-MG cells stained with anti-TMEM39A antibody showed that TMEM39A was located in dot-like structures lying close to the nucleus. TMEM39A probably located to mitochondria or to endosomes. Immunohistochemical analysis of glioma tissue specimens indicated that TMEM39A was markedly upregulated in such samples. Bioinformatic analysis of the Rembrandt knowledge base also supported upregulation of TMEM39A mRNA levels in glioma patients. Together, the results afford strong evidence that TMEM39A is upregulated in glioma cell lines and glioma tissue specimens. Therefore, TMEM39A may serve as a novel diagnostic marker of, and a therapeutic target for, gliomas and other cancers.
Recognition of Transmembrane Protein 39A as a Tumor-Specific Marker in Brain Tumor
Jisoo Park,Hyunji Lee,Quangdon Tran,Kisun Mun,Dohoon Kim,Youngeun Hong,So Hee Kwon,Derek Brazil,Jongsun Park,Seon-Hwan Kim 한국독성학회 2017 Toxicological Research Vol.33 No.1
Transmembrane protein 39A (TMEM39A) belongs to the TMEM39 family. TMEM39A gene is a susceptibility locus for multiple sclerosis. In addition, TMEM39A seems to be implicated in systemic lupus erythematosus. However, any possible involvement of TMEM39A in cancer remains largely unknown. In the present report, we provide evidence that TMEM39A may play a role in brain tumors. Western blotting using an anti-TMEM39A antibody indicated that TMEM39A was overexpressed in glioblastoma cell lines, including U87-MG and U251-MG. Deep-sequencing transcriptomic profiling of U87-MG and U251-MG cells revealed that TMEM39A transcripts were upregulated in such cells compared with those of the cerebral cortex. Confocal microscopic analysis of U251-MG cells stained with anti-TMEM39A antibody showed that TMEM39A was located in dot-like structures lying close to the nucleus. TMEM39A probably located to mitochondria or to endosomes. Immunohistochemical analysis of glioma tissue specimens indicated that TMEM39A was markedly upregulated in such samples. Bioinformatic analysis of the Rembrandt knowledge base also supported upregulation of TMEM39A mRNA levels in glioma patients. Together, the results afford strong evidence that TMEM39A is upregulated in glioma cell lines and glioma tissue specimens. Therefore, TMEM39A may serve as a novel diagnostic marker of, and a therapeutic target for, gliomas and other cancers.
RSS 안전 모델과 SCC 실차 실험에 대한 실효성 연구
이도훈(Dohoon Lee),박상협(Sanghyeop Park),한종호(Jongho Han),박지수(Jisoo Park),이태희(Taehee Lee) 한국자동차공학회 2020 한국자동차공학회 부문종합 학술대회 Vol.2020 No.7
본 논문은 자율주행차량 사고 과실 여부 판단을 위한 RSS 안전 모델과 SAE 2단계에 해당되는 SCC 기능에 대해 실차실험 결과를 기반으로 안전거리에 대한 수학적 모델로부터 현 기술단계에서 실효성이 있는지 알아본다. RSS 안전 모델에서 명시한 변수들에 대해서는 실차 평가시에 계측한 데이터 값들을 적용하고, 차량내부 시스템인 반응시간에 대해서는 실차평가를 통해 계측한 지연시간과 센싱을 통한 시스템임을 감안한 반응시간을 추가하였으며, 이를 통해 실차에서의 SCC 시스템이 RSS 안전 모델에 실효성을 가지는지 확인한다.
( Hee Seung Hong ),( Jiwon Baek ),( Jae Chul Park ),( Ho-su Lee ),( Dohoon Park ),( A-ran Yoon ),( Soo Jung Park ),( Sung Noh Hong ),( Seong-joon Koh ),( Chang Kyun Lee ),( Bo-in Lee ),( Sung Wook Hwa 대한소화기기능성질환·운동학회 2022 Gut and Liver Vol.16 No.6
Background/Aims: Chronic enteropathy associated with SLCO2A1 gene (CEAS), an inherited disease characterized by nonspecific intestinal ulcers, has emerged in the Japanese population via loss-of-function mutations in the SLCO2A1 gene. We aimed to investigate the clinical and genetic characteristics of Korean patients diagnosed with CEAS. Methods: From July 2018 to July 2021, we performed Sanger sequencing of the SLCO2A1 gene in 46 patients with chronic intestinal ulcers. CEAS was confirmed based on known SLCO2A1 mutations. We summarized the clinical characteristics of patients with confirmed CEAS. Results: Fourteen out of 46 patients (30.4%) had genetically confirmed CEAS, and two SLCO2A1 variants were detected (splicing site variant c.940+1G>A and nonsense mutation [p.R603X] in SLCO2A1). Twelve patients (85.7%) were females and the median age at diagnosis of CEAS was 44.5 years. All patients presented with abdominal pain, and 13 patients (92.9%) presented with anemia (median hemoglobin, 9.6 g/dL). Ten patients (71.4%) had hypoalbuminemia (median, 2.7 g/dL). The most commonly involved site was the ileum (13/14, 92.9%). Manifestations of primary hypertrophic osteoarthropathy (PHO), such as digital clubbing, pachydermia, and periostosis were observed in five patients (28.6%) and two male patients and one female patient satisfied all major PHO diagnostic criteria. Conclusions: The clinical and genetic characteristics of Korean patients with confirmed CEAS were similar to those reported in the literature. CEAS should be considered in the differential diagnosis for patients with unexplained chronic nonspecific ulcers of the small intestine. (Gut Liver 2022;16:942-951)
Comparative Study Between Watson for Oncology and Tumor Boards for Treatment in Breast Cancer
Dohoon Kim,Ah Rem Jung,Joung Won Na,Yun Yeong Kim,Hee Kyung Ahn,Ki Hoon Sung,Min Ji Hong,Eun Young Yoo,Sang Yu Nam,Kyu Chan Lee,Eun Kyung Cho,Hye Young Choi,Heung Kyu Park,Yong Soon Chun 대한외과학회 2018 대한외과학회 학술대회 초록집 Vol.2018 No.11