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David Price,Henry Chrystyn,Alan Kaplan,John Haughney,Miguel Román-Rodríguez,Annie Burden,Alison Chisholm,Elizabeth V. Hillyer,Julie von Ziegenweidt,Muzammil Ali,Thys van der Molen 대한천식알레르기학회 2012 Allergy, Asthma & Immunology Research Vol.4 No.4
Purpose: Correct use of inhaler devices is fundamental to effective asthma management but represents an important challenge for patients. The correct inhalation manoeuvre differs markedly for different inhaler types. The objective of this study was to compare outcomes for patients prescribed the same inhaler device versus mixed device types for asthma controller and reliever therapy. Methods: This retrospective observational study identified patients with asthma (ages 4-80 years) in a large primary care database who were prescribed an inhaled corticosteroid (ICS) for the first time. We compared outcomes for patients prescribed the same breath-actuated inhaler (BAI) for ICS controller and salbutamol reliever versus mixed devices (BAI for controller and pressurised metered-dose inhaler [pMDI] for reliever). The 2-year study included 1 baseline year before the ICS prescription (to identify and correct for confounding factors) and 1 outcome year. Endpoints were asthma control (defined as no hospital attendance for asthma,oral corticosteroids, or antibiotics for lower respiratory tract infection) and severe exacerbations (hospitalisation or oral corticosteroids for asthma). Results: Patients prescribed the same device (n=3,428) were significantly more likely to achieve asthma control (adjusted odds ratio, 1.15;95% confidence interval [CI], 1.02-1.28) and recorded significantly lower severe exacerbation rates (adjusted rate ratio, 0.79; 95% CI, 0.68-0.93) than those prescribed mixed devices (n=5,452). Conclusions: These findings suggest that, when possible, the same device should be prescribed for both ICS and reliever therapy when patients are initiating ICS.
Sung Il Yang,David Kaplan 생화학분자생물학회 1995 BMB Reports Vol.28 No.4
The GTPase activating protein (GAP) can function both as a negative regulator and an effector of p21^(ras). Overexpression of GAP in NIH-3T3 cells has been shown to inhibit transformation by ryas or src. To investigate the function of GAP in a differentiative system, we overexpressed this protein in the nerve growth factor (NGF)-responsive PC12 cell line. Two-fold overexpression of GAP caused a delay of several days in the onset of NGF- but not FGF-induced neuronal differentiation of PC12 cells. However, the NGF-induced activation or tyrosine phosphorylation of upstream (Trk, PLC-γ1, SHC) and downstream (B-Raf and p44^(mapk/erk1)) components of p21^(ras) signalling cascade was not altered by GAP overexpression. Therefore, the change of phenotype induced by GAP was probably not due to GAP functioning as a negative regulator of p21^(ras). Rather, we found that NGF-induced tyrosine phosphorylation of SNT, a specific target of neurotrophin-induced tyrosine kinase activity. was inhibited by GAP overexpression. SNT is thought to function upstream or independent of p21^(ras). Thus in PC12 cells, overexpressed GAP may control the rate of neuronal differentiation through a pathway involving SNT rather than the p21^(ras) signalling pathway.
Yang, Sung-Il,Kaplan, David Korean Society for Biochemistry and Molecular Biol 1995 Journal of biochemistry and molecular biology Vol.28 No.4
The GTPase activating protein (GAP) can function both as a negative regulator and an effector of $p21^{ras}$. Overexpression of GAP in NIH-3T3 cells has been shown to inhibit transformation by ms or src. To investigate the function of GAP in a differentiative system, we overexpressed this protein in the nerve growth factor (NGF)-responsive PC12 cell line. Two-fold overexpression of GAP caused a delay of several days in the onset of NGF- but not FGF-induced neuronal differentiation of PC12 cells. However, the NGF-induced activation or tyrosine phosphorylation of upstream (Trk, PLC-${\gamma}1$, SHC) and downstream (B-Raf and $p44^{mapk/erk1}$) components of $p21^{ras}$, signalling cascade was not altered by GAP overexpression. Therefore, the change of phenotype induced by GAP was probably not due to GAP functioning as a negative regulator of $p21^{ras}$. Rather, we found that NGF-induced tyrosine phosphorylation of SNT, a specific target of neurotrophin-induced tyrosine kinase activity, was inhibited by GAP overexpression. SNT is thought to function upstream or independent of $p21^{ras}$. Thus in PC12 cells, overexpressed GAP may control the rate of neuronal differentiation through a pathway involving SNT rather than the $p21^{ras}$ signalling pathway.
Compositional consistancy of a heteropolysaccharide-7 produced by Beijerinckia indica
Lee, Jin W.,Yeomans, Walter G.,Allen, Alfred L.,Gross, Richard A.,Kaplan, David L. 東亞大學校附設遺傳工學硏究所 1998 遺傳工學硏究 Vol.- No.5
The component sugars of heteropolysaccharide-7(PS-7) produced by Beijerinckia indica were rhamnose and glucose (1.0:4.8,mol:mol) by gas chromatographic analysis. Galacturonic acid, previously reported as a repeat unit of PS-7, was not found in purified PS-7. The yield of PS-7 varied with physiological conditions, such as concentration of carbon source and initial pH of medium, but the molar ratio of rhamnose to glucose stayed within 1.0 to 4.6-5.1. B indica utilized glucose and some glucose analogs as carbon sources and produced exopolymers, although there was no direct incorporation of these sugars into PS-7. The molar ratio of rhamnose to glucose in each polymer synthesized from glucose-related sugars showed no significant variation(1.0 to 4.5-4.7).
Production of zoogloea gum by Zoogloea ramigera with glucose analogs
Lee, Jin W.,Yeomans, Walter G.,Allen, Alfred L.,Gross, Richard A.,Kaplan, David L. 東亞大學校附設遺傳工學硏究所 1998 遺傳工學硏究 Vol.- No.5
Zoolgans with altered sugar composition were synthesized by Zoogloea ramigera by varying the glucose concentration and initial medium pH. The relative mol% of the sugar components, glucose and galactose, in the exopolymer made with 2% (w/v) glucose as the carbon source was 66 and 34%, respectively. By varying the glucose concentration and initial medium pH, the mol% ratios of glucose to galactose in zooglan ranged from 70:30 to 58:42. Also, glucose analogs, 3-O-methyl-D-glucose, 2-amino-2-deoxy-D-glucose, and 2-acetamido-2-deoxy-D-glucose, were used as a co-substrate with glucose to produce to produce modified zooglans. The mol% ratios of glucose to galactose in exopolymers produced by co-feeding glucose analogs ranged from 70:30 to 9:91.
Lee, Jin W.,Yeomans, Walter G.,Allen, Alfred L.,Gross, Richard A.,Kaplan, David L. 東亞大學校附設遺傳工學硏究所 1998 遺傳工學硏究 Vol.- No.5
The cell growth, production of exopolymers, and the molar ratio of glucose to mannose in the water-soluble non curdlan type exopolymer-B (WSNCE-B), which is one of three exopolymers purified from the culture of Agrobacterium sp. varied with carbon source, culture medium, and initial medium pH. The molar percentage of rhamnose, a ninor component in WSNCE-B, varied up to 13%, dependent on physiological condition. No rhamnose was found in the WSNCE-B purified from the culture with initial medium pH>6.8. The relative amount of mannose in WSNCE-B increased regularly with the amount of yeast extract added to the mineral salts medium. The relative amounts of glucose, mannose, and rhamnose in the WSNCE-B can be controlled by varying culture conditions.
Aging and Cancer : A molecular signature of human breast epithelial cell invasion
( Hae Young Yong ),( Jae In Song ),( Daniela Cukovic ),( Sridevi Salagrama ),( David Kaplan ),( David Putt ),( Hye Sook Kim ),( Alan Dombkowski ),( Hyeong Reh Choi Kim ),( A Ree Moon ) 한국생화학분자생물학회 (구 한국생화학회) 2008 생화학분자생물학회 춘계학술발표논문집 Vol.2008 No.-