결합조직형성 법랑모세포종의 방사선학적 소견 : 증례보고 3례

최다혜,허경회,문제운,이원진,허민석,이삼선,최순철,박관수 대한구강악안면방사선학회 2006 Imaging Science in Dentistry Vol.37 No.1

Desmoplastic ameloblastoma is a rare histologic variant of ameloblastoma. It shows important differences in anatomic distribution, histologic appearance, and radiographic findings compared with the general type of ameloblastoma. It is histologically characterized by an abundance of densely collagenous stroma and radiographically a mixed radiolucent-radiopaque lesion. We present three cases of desmoplastic ameloblastoma. All the patients complained on buccal swelling with or without pain and the sites of occurrence were the anterior and the premolar region. Plain radiographs showed mixed radiopaque-radiolucent lesion with ill-defined or diffuse sclerotic margin and no external root resorption. Additionally, CT scans revealed buccal expansion and relatively well-defined margin of the lesions. The clinical and radiographic features of the presented cases were compared with those of the desmoplastic ameloblastoma in the previous literatures. (Korean J Oral Maxillofac Radiol 2006; 36 : 63-8)

안내염과 대장암이 동반된 재발성 간농양

전승정,김태헌,류민선,오다연,송명은,이신아,류재인,김혜인,문일환,유권 이화여자대학교 의과학연구소 2011 EMJ (Ewha medical journal) Vol.34 No.2

The causes of pyogenic liver abscess has been known as biliary tract disease or intrabadominal infection but the large proportions of the patients has no apparent underlying disorders. Recently colonic mucosal lesions were reported in patients with cryptogenic liver abscess and it has been suggested that colonic mucosal break may play a role in developing liver abscess in otherwise healthy patients. We experienced a patient of severe recurrent liver abscess complicated with endophthalmitis only 3 months after successful treatment of initial cryptogenic liver abscess and a polypoid colon cancer was discovered by chance. It seems prudent to proceed colonoscopic examination in patients with cryptogenic liver abscess especially when it is recurrent.

Factors Associated Readmission Following Hospitalization for Pneumonia in South Korea

( Da Hye Moon ),( Woo Jin Kim ),( Eun Sil Choi ),( Heui Sug Jo ) 대한결핵 및 호흡기학회 2020 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.128 No.0

Background Community-acquired pneumonia is a frequent, potentially serious disease in people aged >65 years and one of the leading causes of hospitalization and mortality worldwide. Hospital readmissions are an indicator of poor health care quality. Patient-, hospital-, and healthcare system related factors are associated with pneumonia readmissions. The aim of this evaluation was to assess several factors associated with pneumonia-readmission in South Korea. Methods A retrospective cohort study was designed using the National Health Insurance Service-Elderly Cohort Database (NHIS-ECD). During study the period between January 2013 and December 2015, we estimated the incidence rate of hospitalized CAP in adults ≥ 70 years in South Korea using the NHIS-ECD. This study included demographic information, principal diagnosis or comorbidities based on the International Classification of Disease, 10th Revision (ICD-10), date of admission and discharge, drug prescription, and treatment fees through computerized management. Readmission was defined as hospitalization within 30 days of discharge. Results During the study period, 21,149 patients were diagnosed to have pneumonia admission. When gender is compared, male readmission rate for pneumonia was 16%(n=1628), higher than 13.1%(n=1433) for female. In addition, the readmission rate for age; 70-74yr, 75-79yr, 80-84yr, ≥85yr, were 12.6%, 13.6%, 15.2%, and 15.7%, respectively. The readmission rate was higher in hospitals (16.5%) than in general hospitals (13.5%). The longer the treatment period was 29 Days and More (31.2%), the higher the pneumonia readmission rate. And Readmissions were higher in rural area (15.5%) than in urban area (13.3%). Conclusions Pneumonia-specific 30-day readmission was significantly associated with the gender, age, hospital type, treatment period, patient’s residence. A range of patient factor and social factors affect the risk of pneumonia readmission in South Korea.

Correlation between Telomere Length and Chronic Obstructive Pulmonary Disease-Related Phenotypes: Results from the Chronic Obstructive Pulmonary Disease in Dusty Areas (CODA) Cohort

( Da Hye Moon ),( Jeeyoung Kim ),( Myoung Nam Lim ),( So Hyen Bak ),( Woo Jin Kim ) 대한결핵 및 호흡기학회 2021 Tuberculosis and Respiratory Diseases Vol.84 No.3

Background: Chronic obstructive pulmonary disease (COPD) is a common chronic respiratory disease with increased prevalence in the elderly. Telomeres are repetitive DNA sequences found at the end of the chromosome, which progressively shorten as cells divide. Telomere length is known to be a molecular marker of aging. This study aimed to assess the relationship between telomere length and the risk of COPD, lung function, respiratory symptoms, and emphysema index in Chronic Obstructive Pulmonary Disease in Dusty Areas (CODA) cohort. Methods: We extracted DNA from the peripheral blood samples of 446 participants, including 285 COPD patients and 161 control participants. We measured absolute telomere length using quantitative real-time polymerase chain reaction. All participants underwent spirometry and quantitative computed tomography scan. Questionnaires assessing respiratory symptoms and the COPD Assessment Test was filled by all the participants. Results: The mean age of participants at the baseline visit was 72.5±7.1 years. Males accounted for 72% (321 participants) of the all participants. The mean telomere length was lower in the COPD group compared to the non-COPD group (COPD, 16.81±13.90 kb; non-COPD, 21.97±14.43 kb). In COPD patients, 112 (75.7%) were distributed as tertile 1 (shortest), 91 (61.1%) as tertile 2 and 82 (55%) as tertile 3 (longest). We did not find significant associations between telomere length and lung function, exacerbation, airway wall thickness, and emphysema index after adjusting for sex, age, and smoking status. Conclusion: In this study, the relationship between various COPD phenotypes and telomere length was analyzed, but no significant statistical associations were shown.

Identification of Serial DNA Methylation Changes in the Blood Samples of Patients with Lung Cancer

( Da Hye Moon ),( Sung Ok Kwon ),( Woo Jin Kim ),( Yoonki Hong ) 대한결핵 및 호흡기학회 2019 Tuberculosis and Respiratory Diseases Vol.82 No.2

Background: The development of lung cancer results from the interaction between genetic mutations and dynamic epigenetic alterations, although the exact mechanisms are not completely understood. Changes in DNA methylation may be a promising biomarker for early detection and prognosis of lung cancer. We evaluated the serial changes in genomewide DNA methylation patterns in blood samples of lung cancer patients. Methods: Blood samples were obtained for three consecutive years from three patients (2 years before, 1 year before, and after lung cancer detection) and from three control subjects (without lung cancer). We used the MethylationEPIC BeadChip method, which covers the 850,000 bp cytosine-phosphate-guanine (CpG) site, to conduct an epigenome-wide analysis. Significant differentially methylated regions (DMRs) were identified using p-values <0.05 in a correlation test identifying serial methylation changes and serial increase or decrease in β value above 0.1 for three consecutive years. Results: We found three significant CpG sites with differentially methylated β values and 7,105 CpG sites with significant correlation from control patients without lung cancer. However, there were no significant DMRs. In contrast, we found 11 significant CpG sites with differentially methylated β values and 10,562 CpG sites with significant correlation from patients with lung cancer. There were two significant DMRs: cg21126229 (RNF212) and cg27098574 (BCAR1). Conclusion: This study revealed DNA methylation changes that might be implicated in lung cancer development. The DNA methylation changes may be the possible candidate target regions for the early detection and prevention of lung cancer.

Identification of Serial DNA Methylation Changes in the Blood Samples of Patients with Lung Cancer

Moon, Da Hye,Kwon, Sung Ok,Kim, Woo Jin,Hong, Yoonki The Korean Academy of Tuberculosis and Respiratory 2019 Tuberculosis and Respiratory Diseases Vol.82 No.2

Background: The development of lung cancer results from the interaction between genetic mutations and dynamic epigenetic alterations, although the exact mechanisms are not completely understood. Changes in DNA methylation may be a promising biomarker for early detection and prognosis of lung cancer. We evaluated the serial changes in genome-wide DNA methylation patterns in blood samples of lung cancer patients. Methods: Blood samples were obtained for three consecutive years from three patients (2 years before, 1 year before, and after lung cancer detection) and from three control subjects (without lung cancer). We used the MethylationEPIC BeadChip method, which covers the 850,000 bp cytosine-phosphate-guanine (CpG) site, to conduct an epigenome-wide analysis. Significant differentially methylated regions (DMRs) were identified using p-values <0.05 in a correlation test identifying serial methylation changes and serial increase or decrease in ${\beta}$ value above 0.1 for three consecutive years. Results: We found three significant CpG sites with differentially methylated ${\beta}$ values and 7,105 CpG sites with significant correlation from control patients without lung cancer. However, there were no significant DMRs. In contrast, we found 11 significant CpG sites with differentially methylated ${\beta}$ values and 10,562 CpG sites with significant correlation from patients with lung cancer. There were two significant DMRs: cg21126229 (RNF212) and cg27098574 (BCAR1). Conclusion: This study revealed DNA methylation changes that might be implicated in lung cancer development. The DNA methylation changes may be the possible candidate target regions for the early detection and prevention of lung cancer.

EMTP를 이용한 12-펄스 정류기 모델링

문다혜(Da-Hye Moon),성노규(No-Kyu Seong),김철환(Chul-Hwan Kim) 대한전기학회 2008 대한전기학회 학술대회 논문집 Vol.2008 No.7(초록집)

Schisandrin A suppresses lipopolysaccharide-induced inflammation and oxidative stress in RAW 264.7 macrophages by suppressing the NF-κB, MAPKs and PI3K/Akt pathways and activating Nrf2/HO-1 signaling

Kwon, Da Hye,Cha, Hee-Jae,Choi, Eun Ok,Leem, Sun-Hee,Kim, Gi-Young,Moon, Sung-Kwon,Chang, Young-Chae,Yun, Seok-Joong,Hwang, Hye Jin,Kim, Byung Woo,Kim, Wun-Jae,Choi, Yung Hyun UNKNOWN 2018 INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE Vol.41 No.1

<P>Schisandrin A is a bioactive lignan occurring in the fruits of plants of the <I>Schisandra</I> genus that have traditionally been used in Korea for treating various inflammatory diseases. Although the anti-inflammatory and antioxidant effects of lignan analogues similar to schisandrin A have been reported, the underlying molecular mechanisms have remained elusive. In the present study, schisandrin A significantly suppressed the lipopolysaccharide (LPS)-induced production of the key pro-inflammatory mediators nitric oxide (NO) and prostaglandin E<SUB>2</SUB> by suppressing the expression of inducible NO synthase and cyclooxygenase-2 at the mRNA and protein levels in RAW 264.7 macrophages. Furthermore, schisandrin A was demonstrated to reduce the LPS-induced secretion of pro-inflammatory cytokines, including tumor necrosis factor-α and interleukin-1β; this was accompanied by a simultaneous decrease in the respective mRNA and protein levels in the macrophages. In addition, the LPS- induced translocation of nuclear factor-κB (NF-κB), as well as activation of mitogen-activated protein kinases (MAPKs) and phosphatidylinositol-3 kinase (PI3K)/Akt pathways were inhibited by schisandrin A. Furthermore, schisandrin A significantly diminished the LPS-stimulated accumulation of intracellular reactive oxygen species, and effectively enhanced the expression of NF erythroid 2-related factor 2 (Nrf2) and heme oxygenase-1 (HO-1). These results suggested that schisandrin A has a protective effect against LPS-induced inflammatory and oxidative responses in RAW 264.7 cells by inhibiting the NF-κB, MAPK and PI3K/Akt pathways; these effects are mediated, at least in part, by the activation of the Nrf2/HO-1 pathway. Based on these results, it is concluded that schisandrin A may have therapeutic potential for treating inflammatory and oxidative disorders caused by over-activation of macrophages.</P>

EMTP를 이용한 12-펄스 정류기 모델링

문다혜(Da-Hye Moon),성노규(No-Kyu Seong),김철환(Chul-Hwan Kim) 대한전기학회 2008 대한전기학회 학술대회 논문집 Vol.2008 No.7

모란봉악단 "신작음악회 공연" 의미와 시사점

강동완 ( Dong Wan Kang ) , 문다혜 ( Da Hye Moon ) 조선대학교 동북아문제연구소 2015 동북아연구 Vol.30 No.1

김정은은 모란봉악단을 통해 ``열린 음악정치``를 구현하고 있다. 2012년 7월 김정은에 의해 결성된 모란봉악단은 파격적인 시범공연 이후 북한의 중요 행사와 기념일의 축하공연을 주도하였고 현재는 북한 문화예술분야의 ``모범집단``으로 자리 잡았다. 주목할 공연은 2014년 9월 진행된 "모란봉악단의 신작음악회"이다. 이 공연은 이전의 모란봉악단 공연과는 다르게 김정은 시대의 창작곡으로만 구성되었으며, 특정 행사를 기념하는 성격이 아니라는 특징이 있다. 이는 신작음악회에서 발표된 노래와 공연구성을 통해 김정은 시대의 한 단면을 보다 명확히 찾을 수 있음을 의미한다. 본 연구는 모란봉악단이 신작음악회에서 선보인 신곡들의 내용과 구성을 분석하여 시사점을 찾는 것을 목적으로 한다. 신작음악회의 신곡과 공연구성이 의도하는 정치적 의미를 살펴보고 북한체제의 특성을 연계하여 시사점을 살펴본다. 이번 공연에서 발표된 곡들은 크게 네 부분으로 구분할 수 있다. 첫째, 김정은 찬양과 충성맹세를 담은 곡 둘째, 당의 정책을 반영한 곡, 셋째, 북한체제 결속력 향상을 위한 곡, 넷째, 북한의 혁명투쟁을 상기시키는 곡으로 나눌 수 있었다. 그리고 이를 통해 도출한 시사점을 제시한다. 모란봉악단 공연에 대한 지속적인 분석을 통해 북한문화예술 분야의 특성은 물론 북한 정치와 문화의 연관성 등을 파악할 수 있는 논의로 확대할 필요가 있다. Kim Jung-Eun has been implementing ``Open music politics`` through Moranbong band. The band was formed in July 2012 by Kim Jung-Eun and they appeared at important events and anniversaries after their extraordinary performance. Now they became the ``Role Group`` of North Korean Arts. ``New Music Concert`` was a notable performance given on September 2014. The Concert was only composed of songs which were written in Kim Jung-Eun``s era and it had special features that did not celebrate a particular event. It shows that we can clearly see a glimpse of Kim Jung-Eun``s era through the songs and concert performances of the ``New Music Concert``. This study analyzes the contents and composition of the new songs which were performed at the concert and find the implications. The study is looking for the political implications of the new songs and the concert performances and to link the characteristics of the North Korean regime with implications. Performed songs can be categorized into four parts. First, songs that contain praise and pledge allegiance to Kim Jung-Eun. Second, songs that reflect the party``s policy. Third, songs that improve the solidarity of the North Korean regime. Finally, songs that remind people of the revolutionary struggle in North Korean history. Through these categories, the concert intends to emphasize Kim Jung-Eun``s governing legitimacy and thought.