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( Bark Lynn Lew ),( Hee Ryung Cho ),( Sik Haw ),( Hwi Jun Kim ),( Joo Ho Chung ),( Woo Young Sim ) 대한피부과학회 2012 Annals of Dermatology Vol.24 No.1
Background: Alopecia areata is marked by autoimmune assault on the hair follicle resulting in hair loss. T helper 17 cell subset has important roles in protecting the host against extracellular pathogens, however, also promotes inflammatory pathology in autoimmune disease, and it expresses both interleukin (IL)-17A and IL-17F, which can signal via the IL-17 receptor A. Objective: To investigate the significance of IL17A and IL17RA gene polymorphisms in the susceptibility to alopecia areata. Methods: We conducted case-control association study of 238 alopecia areata patients and 270 matched healthy controls. Allele frequency of total 2 single nucleotide polymorphims in the IL17A gene and 4 single nucleotide polymorphims in the IL17RA gene were studied. The statistical analyses were performed according to onset age, the presence of familyhistory, clinical subtypes, and presence of nail involvement or body hair involvement. Results: One single nucleotide polymorphim (rs879577) of IL17RA gene showed significant difference between alopecia areata patients group and controls group (p= 0.0288). One single nucleotide polymorphim (rs4819554) of IL17RA gene showed significant difference between the early onset and late onset alopecia areata (p=0.0421). Conclusion: IL17RA gene polymorphism might contribute to the increased susceptibility to alopecia areata in Korean population, and IL17RA gene polymorphism may be associated with onset age. (Ann Dermatol 24(1) 61∼65, 2012)
( Bark Lynn Lew ),( Woo Young Sim ),( Nack In Kim ) 대한피부과학회 2009 Annals of Dermatology Vol.21 No.4
Background: Toll-like receptors (TLRs) are expressed by human epidermal keratinocytes and are involved in immune responses. Objective: The goal of this was to investigate the expression of TLR2 in response to bacterial antigens, cytokines, and different calcium concentrations. Methods: The expression of TLR2 was assessed after stimulation by lipoteichoic acid (LTA) and streptolysin O (SLO). In addition, TLR2 expression was evaluated after treatment with IFN-γ and TNF-α, and different concentrations of calcium. The expression levels of TLR2 mRNA and protein were studied using RT-PCR and Western blot analysis. Results: Cultured human epidermal keratinocytes constitutively expressed TLR2 and the expression was stimulated by LTA and SLO; in addition, IFN-γ and TNF-α upregulated TLR2 expression. However, the changes in TLR2 expression associated with the calcium concentrations were insignificant. Conclusion: TLR2 expression increased with the concentration and duration of bacterial pathogens and this increase was amplified by several cytokines, from activated keratinocytes and other cells. (Ann Dermatol 21(4) 337~344, 2009)