한국의 시험관아기 시술 30년, 거버넌스의 부재와 위험의 증가: 전문가 역할을 중심으로

하정옥 ( Ha Jung Ok ) 한국과학사학회 2014 한국과학사학회지 Vol.36 No.1

This paper examines the 30-year history of in vitro fertilization (IVF) in Korea in terms of the role and social responsibility of experts. International comparison studies on IVF have consistently ranked South Korea as one of the countries with highest average number of embryo transferred. The continuous rise of IVF treatments in South Korea has increased the multiple births in the country almost twice over the last 20 years. However, multiple births can be risky to the health of newborn babies. In general, countries, which have established national registries and conducted follow-up surveys on the children conceived via IVF treatments, show substantial decreases in the number of embryos transferred. In South Korea’s case, there are no accurate records or follow-up surveys on babies born via IVF. Though there are clearly many reasons why this situation exists, this study approaches the subject rather from the standpoint of the role and social responsibility of experts. In countries where expert organizations were actively involved in establishing governance for IVF, it was possible to prevent increases in multiple pregnancies and lower the health risk of newborns. This strongly shows that the proper control of these technologies is possible when expert organizations take full responsibility and make active and dedicated efforts to institutionalize the outcomes of their work.

Development of New Vitrification Method for Preimplantation Mouse Embryo

Ha, A-Na,Fakruzzaman, Md.,Lee, Kyeong-Lim,Wang, Erdan,Lee, Jae-Ik,Min, Chan-Sik,Kong, Il-Keun The Korean Society of Embryo Transfer 2013 한국동물생명공학회지 Vol.28 No.2

The purpose of this study was attempted to new methods in mammalian embryos vitrification. This method was affected to increase of the embryo vitrification efficiency and it would be applied to the field of embryo transfer to recipient by modified loading method of embryo into 0.25 ml plastic straw. The frozen mouse embryos were carried out warmed from two different cell stages (8-cell and blastocyst, respectively) by attachment of an embryo in the vitrification straw (aV) method. All groups were cultured in M-16 medium to determine the development and survivability for 24 h, respectively. Results shown that, the survivability of two different groups were significantly different (94.8% vs. 70.9%). Total cell number was not significantly different the non-frozen blastocyst ($99.7{\pm}12.4$) compared to the post-thaw blastocyst ($94.8{\pm}15.1$). From the 8-cell embryo, total cell number of frozen blastocysts were significantly lower than others groups ($74.7{\pm}14.6$, p<0.05). In the case of cell death analysis, the blastocysts from non-frozen and frozen-thawed 8-cell group were not different ($0.0{\pm}0.0$ vs. $1.9{\pm}3.1$, p>0.05). However, the apoptotic nuclei of blastocyst were significantly observed the frozen-thawed group ($5.4{\pm}4.4$) compared to non-frozen group (p<0.05). Therefore, this new method of embryos using in-straw dilution and direct transfer into other species would be more simple procedure of embryo transfer rather than step-wise dilution method and cryopreservation vessels, so we can be applied in animal as well as human embryo cryopreservation in further.

Development of New Vitrification Method for Preimplantation Mouse Embryo

A-Na Ha,Md. Fakruzzaman,Kyeong-Lim Lee,Erdan Wang,Jae-Ik Lee,Chan-Sik Min,Il-Keun Kong 韓國受精卵移植學會 2013 한국동물생명공학회지 Vol.28 No.2

The purpose of this study was attempted to new methods in mammalian embryos vitrification. This method was affected to increase of the embryo vitrification efficiency and it would be applied to the field of embryo transfer to recipient by modified loading method of embryo into 0.25 ml plastic straw. The frozen mouse embryos were carried out warmed from two different cell stages (8-cell and blastocyst, respectively) by attachment of an embryo in the vitrification straw (aV) method. All groups were cultured in M-16 medium to determine the development and survivability for 24 h, respectively. Results shown that, the survivability of two different groups were significantly different (94.8% vs. 70.9%). Total cell number was not significantly different the non-frozen blastocyst (99.7 ± 12.4) compared to the post-thaw blastocyst (94.8 ± 15.1). From the 8-cell embryo, total cell number of frozen blastocysts were significantly lower than others groups (74.7 ± 14.6, p<0.05). In the case of cell death analysis, the blastocysts from non-frozen and frozen-thawed 8-cell group were not different (0.0 ± 0.0 vs. 1.9 ± 3.1, p>0.05). However, the apoptotic nuclei of blastocyst were significantly observed the frozen-thawed group (5.4 ± 4.4) compared to non-frozen group (p<0.05). Therefore, this new method of embryos using in-straw dilution and direct transfer into other species would be more simple procedure of embryo transfer rather than step-wise dilution method and cryopreservation vessels, so we can be applied in animal as well as human embryo cryopreservation in further.

새로운 임신 기술과 '위험', 그리고 아픈 아이들 : 보조생식술 결과의 국제비교를 중심으로

하정옥(Ha, Jung-Ok) 한국가족학회 2012 가족과 문화 Vol.24 No.2

이 논문은 새로운 임신 기술이 수반하는 '위험'에 대해, 특히 체외수정(IVF) 기술로 태어난 아이들 건강 조사 연구를 중심으로 살펴본다. 흔히 시험관아기로 불리는 이 기술은 불임부부에게 자신의 아이를 가질 수 있는 희망을 준 기술로 찬사를 받았고 전 세계에 널리 확산 되었다. 그런데 이로부터 태어난 아이들의 건강에 대한 우려가 유럽과 북미를 중심으로 제기 되었다. 이러한 우려는 아이들에 대한 추적조사 자료와 함께 실증적으로 제기되었고, 이에 대한 대책으로 체외수정 시술에서 한 번에 이식하는 배아의 수에 대한 규제가 이루어졌다. 그런데 한국을 비롯하여 아시아 국가에서는 이러한 추적조사가 거의 이루어진 바 없고 한번에 이식하는 배아의 수도 그동안 별 변화가 없었다. 이와 함께 전체 출생 인구에서 다태아가 차지하는 비율은 급격히 증가하고 있다. 또 다른 한편, 전 세계적으로도 아이들에 대한연구는 많이 이루어진 반면 이 기술이 여성에 미치는 영향에 대해서는 소수의 연구가 있을뿐이다. 이러한 점에서 이 기술 '위험'의 인지와 대책 마련에서 지구적 불균등을, '위험' 문제구성에서 성별 정치의 일면을 읽을 수 있다. 또한 무엇이 '위험'으로 간주되고 어떤 대책이 마련되는가를 보면 기술 위험의 사회적 구성 또한 발견할 수 있다. This paper intends to study the risks of technology, particularly in terms of the health outcome surveys and follow-up of children born through IVF (in vitro fertilization, also known more colloquially as test-tube babies). From the early stage of IVF's development, the disabilities of children born through IVF was the key target for risk management practices, and the follow-up studies of the children born through IVF have been working through samples or complete enumeration surveys in mostly European countries. The results showed that the overall health outcomes of IVF children were relatively poorer than for other children, and the multiple pregnancies and births from multiple embryo implantations was pointed out as the main cause for this. Such an analysis result was followed by legislative or administrative regulation of the number of embryos allowed to be transferred in actual IVF practice. Risk management status differs from country to country. Since the first 'test tube baby' was born in Korea in 1985, 235,000 cases were accumulated between 1992, when official reporting began, and 2007. However, no follow-up study of the children has been conducted nor has the official regulation of the number of embryos been transferred along with the technology. Even today, the rate of transferring 4 or more embryos in an IVF procedure is more than 50% in Korea, and the ratio of multiple-births to the total number of babies born began rapidly increasing in the 2000's. I suggest that the risk of technology should be considered not just as a side effect of technological development but as an essential part of those processes. Furthermore, the social construction of the risks, which considers risk according to the locality's status of technological development, can also be observed.