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The migration of vascular smooth muscle cells (VSMC) may play a key role in the development of atherosclerosis. Evodia officinalis DODE (EO), an eminent herbal plant, has been widely used in traditional Korean medicine for the treatment of vascular di...
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RISS 인기검색어
오수유 메탄올 추출물의 항염증 및 항유주 효과 = Anti-inflammatory and anti-migration effect of methanol extract of Evodia officinalis DODE in HASMC
한글로보기https://www.riss.kr/link?id=T11632986
- 저자
-
발행사항
서울: 동국대학교 대학원, 2009
-
학위논문사항
학위논문(석사) -- 동국대학교 대학원 대학원 , 한의학과 , 2009. 2
-
발행연도
2009
-
작성언어
한국어
- 주제어
-
DDC
615.32 판사항(22)
-
발행국(도시)
서울
-
형태사항
28장: 삽도; 26cm.
-
일반주기명
동국대학교 논문은 저작권에 의해 보호받습니다.
지도교수:박선동 - DOI식별코드
-
소장기관
- 동국대학교 중앙도서관
- 동국대학교 중앙도서관
-
0
상세조회 -
0
다운로드
부가정보
다국어 초록 (Multilingual Abstract)
The migration of vascular smooth muscle cells (VSMC) may play a key role in the development of atherosclerosis. Evodia officinalis DODE (EO), an eminent herbal plant, has been widely used in traditional Korean medicine for the treatment of vascular diseases such as hypertension. The crude extract of EO contains phenolic compounds that are effective in protecting liver microsomes, hepatocytes, and erythrocytes against oxidative damage. Also, several active components such as tanshinones, D(+) 3,4-dihydroxyphe
nol lactic acid, protocatechuic aldehyde, salvianolic acids and rosmarinic acid have been isolated and identified. But EO has been little found to have an anti-inflammatory and anti-migration activity. Moreover, little is known about its mechanism of action. This study was evaluated to elucidate the inhibitory potential of EO on human aortic smooth muscle cells (HASMC) migration and inflammatory responses. Cytotoxic activity of EO on HASMC was using 5-(3-caroboxymeth-oxyphenyl)-2H-tetra-zolium inner salt (MTS) assay. EO decreased TNF-α-induced IL-8, IL-6 production, and intracellular ICAM-1 and VCAM-1 expression. The matrigel migration assay showed that EO effectively inhibited the TNF-α-induced migration of HASMC. Moreover, EO effectively decreased TNF-α-induced phospho-I-Bκ-α. These results indicate that EO has potential as an anti-inflammatory and -migration activity.
nol lactic acid, protocatechuic aldehyde, salvianolic acids and rosmarinic acid have been isolated and identified. But EO has been little found to have an anti-inflammatory and anti-migration activity. Moreover, little is known about its mechanism of action. This study was evaluated to elucidate the inhibitory potential of EO on human aortic smooth muscle cells (HASMC) migration and inflammatory responses. Cytotoxic activity of EO on HASMC was using 5-(3-caroboxymeth-oxyphenyl)-2H-tetra-zolium inner salt (MTS) assay. EO decreased TNF-α-induced IL-8, IL-6 production, and intracellular ICAM-1 and VCAM-1 expression. The matrigel migration assay showed that EO effectively inhibited the TNF-α-induced migration of HASMC. Moreover, EO effectively decreased TNF-α-induced phospho-I-Bκ-α. These results indicate that EO has potential as an anti-inflammatory and -migration activity.
The migration of vascular smooth muscle cells (VSMC) may play a key role in the development of atherosclerosis. Evodia officinalis DODE (EO), an eminent herbal plant, has been widely used in traditional Korean medicine for the treatment of vascular diseases such as hypertension. The crude extract of EO contains phenolic compounds that are effective in protecting liver microsomes, hepatocytes, and erythrocytes against oxidative damage. Also, several active components such as tanshinones, D(+) 3,4-dihydroxyphe
nol lactic acid, protocatechuic aldehyde, salvianolic acids and rosmarinic acid have been isolated and identified. But EO has been little found to have an anti-inflammatory and anti-migration activity. Moreover, little is known about its mechanism of action. This study was evaluated to elucidate the inhibitory potential of EO on human aortic smooth muscle cells (HASMC) migration and inflammatory responses. Cytotoxic activity of EO on HASMC was using 5-(3-caroboxymeth-oxyphenyl)-2H-tetra-zolium inner salt (MTS) assay. EO decreased TNF-α-induced IL-8, IL-6 production, and intracellular ICAM-1 and VCAM-1 expression. The matrigel migration assay showed that EO effectively inhibited the TNF-α-induced migration of HASMC. Moreover, EO effectively decreased TNF-α-induced phospho-I-Bκ-α. These results indicate that EO has potential as an anti-inflammatory and -migration activity.
목차 (Table of Contents)
- Ⅰ. 서론 = 1
- Ⅱ. 실험재료 및 방법 = 3
- 1. 재료 = 3
- (1) 약재 = 3
- (2) 시약 = 3
- Ⅰ. 서론 = 1
- Ⅱ. 실험재료 및 방법 = 3
- 1. 재료 = 3
- (1) 약재 = 3
- (2) 시약 = 3
- 2. 방법 = 5
- (1) 세포배양 = 5
- (2) MTS assay = 5
- (3) Migration assay = 5
- (4) 유세포 분석기를 이용한 부착분자 발현율 측정 = 6
- (5) Western blot analysis = 6
- (6) 세포 배양액 내의 cytokines 측정 = 7
- 3. 통계처리 = 7
- Ⅲ. 실험결과 = 8
- 1. 오수유 메탄올 추출물의 HASMC에 대한 독성 = 8
- 2. HASMC에서 오수유 메탄올 추출물이 부착분자의 생성에 미치는 영향 = 9
- 3. 오수유 메탄올 추출물이 HASMC의 세포 유주능에 미치는 영향 = 12
- 4. 염증성 사이토카인의 생성량에 미치는 영향 = 15
- 5. NF-κB의 활성에 미치는 영향 = 17
- Ⅳ. 고찰 = 19
- Ⅴ. 결론 = 23
- 참고문헌 = 24
- Abstract = 27
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