비강 및 부비동 악성종양의 예후인자에 관한 면역조직화학적 연구 : p53, Cyclin D1, Cathepsin D 발현 양상 = (A) Immunohistochemical study of prognostic factors of sinonasal malignant tumors : p53, Cyclin D1 and Cathepsin D expression

다국어 초록 (Multilingual Abstract)

Background and Objectives : Various host and tumor parameters, particularly by the tumor size and lymph node metastasis have been studied in an attempt to evaluate and decide the optimal treatment of the patients with in the patients with head and neck carcinomars. However, it has been necessary that the prognostic parameters can be useful to evaluate the biological behaviors of the malignancy. The p53 is tumor suppressor gene and cyclin D1 is cell cycle regulator essential for G1 phase progession. Cathepsin D is lysosomal aspartyl endopeptidase which degrade the extracellular matrix and proteoglycan. But there are still controversy in their clinical meanings in sinonasal malignant tumors. The purpose of this study is to assess the roles of p53, cyclin D1 and cathepsin D expression in sinonasal tumorigenesis.
Materials and Methods : 27 inverted papilloma(IPs), 5 IPS associated with malignant transformation, and 16 squamous cell carcinoma tissue specimens were investigated by immunohistochemical staining for p53, cyclin D1, and cathepsin D. Clinicopathologic values were compared with the incidence of p53, cyclin D1, cathepsin D expression in sinonasal malignant tumors.
Results : p53/cyclin D1 expressions were increased as tumor progressed and these expressions were statistically significant(p<0.05). No significant correlation was found between p53, cyclin D1, cathepsin D and other clinicopathologic factors.
Conclusions: These data suggest that expression of p53, cyclin D1 and cathepsin D may play an important role in the tumorigenesis and progression of sinonasal malignant tumor sequence. And also it is suggested that p53/cyclin Dl expression are useful variables for the prognostic assessment of sinonasal malignant tumors. But it was not enough for the prognosticator based on this result alone. Further studies, such as using molecular biological techniques, will be required to determine p53/cyclin D1 expressions which are related to development or prognosis of sinonasal malignant tumors.

목차 (Table of Contents)

• 목차
• 표목차 = ⅰ
• 도목차 = ⅱ
• ABSTRACT = 1
• Ⅰ. 서론 = 3
• Ⅱ. 대상 및 방법 = 5
• Ⅲ. 결과 = 8
• Ⅳ. 고찰 = 10
• Ⅴ. 결론 = 15
• Ⅵ. 참고문헌 = 16
• Ⅶ. 사진부도 = 25