Efficacy of BIMAN-TANG in treating childhood obesity depending on the days of treatment

다국어 초록 (Multilingual Abstract)

ABSTRACT
Efficacy of BIMAN-TANG in treating childhood obesity depending on the days of treatment.
Young Kwern Lim
Department of Science in Korean Medicine,
Graduate School,
Kyung Hee University
Directed by Professor Hocheol Kim

BIMAN-TANG (BMT) is a prescription containing 8 herbs of Ephedra sinica, Coix lacryma-jobi, Liriope platyphylla, Trichosantes kirilowii, Angelica gigas, Asparagus cochinchinensis, Citrus unshiu and Schizonepet tenuifolia.
In this retrospective study, the 30 days-treatment group (n=16) showed reduction in all of weight, BMI and Obesity index (OI), and its result on BMI and OI was statistically important. The 45~90 days-treatment group (n=23) showed reduction in all of weight, BMI and OI. All of those reductions were statistically important.
The result comparison of the 30 days-treatment group and the 45~90 days-treatment group showed that in the 45~90 days-treatment group, of body weight (–1.6 ± 1.6 kg and –0.2 ± 1.3 kg, respectively; p=0.006) and BMI (–1.4 ± 0.8 kg/m2 and –0.5 ± 0.6 kg/m2, respectively; p=0.003) showed significant reduction. The mean OI of the 45~90 days-treatment group showed significant reduction compared with the 30 days-treatment (–9.7 ± 4.7% and –3.6 ± 3.9%, respectively; p<0.001). The mean height showed no significant difference in both groups.
Most of the patients showed excellent level of compliance. Only two patients complained of short-term mild gastrointestinal disorder and indigestion with stomachache, respectively. Other two patients experienced mild nausea and mild insomnia was observed in one patient.

국문 초록 (Abstract)

한글초록
복약 기간에 따른 비만탕의 소아비만에 대한 치료효과
임영권
경희대학교 대학원
기초한의과학과 본초학 전공
지도교수: 김호철

비만탕은 마황, 율무, 맥문동, 과루인, 당귀, 천문동, 진피, 형개의 8가지 본초로 구성된 처방이다.
이번 후향적 연구에 의하면 30일간 복약한 그룹(n=16)과 45~90일 복약한 그룹(n=23) 모두에서 체중, 체질량지수(BMI), 비만도(OI)가 감소하였다. 그 중 30일복약 그룹의 체질량지수(–0.5 ± 0.6 kg/m2, p=0.005) 비만도(–3.6 ± 3.9%, p=0.002), 45~90일 그룹의 체중(–1.6 ± 1.6 kg, p<0.001) 체질량지수(–1.4 ± 0.8 kg/m2, p<0.001), 비만도(–9.7 ± 4.7%, p<0.001)가 통계적 유의성이 있었다.
30일간 복약한 그룹과 45~90일 복약한 그룹의 차이를 살펴보면, 45~90일 복약한 그룹이 30일간 복약한 그룹에 비해 체중 (–1.6 ± 1.6 kg, –0.2 ± 1.3 kg, p=0.006), 체질량지수(–1.4 ± 0.8 kg/m2 and –0.5 ± 0.6 kg/m2, respectively; p=0.003)와 비만도(–9.7 ± 4.7%, –3.6 ± 3.9%, p<0.001)가 유의하게 감소하였다.
두 그룹 모두 높은 안정성을 보였다. 5명이 부작용을 호소했는데, 가벼운 위장장애를 보인 2명 중 1명은 소화장애가 있었고, 1명은 복통 증상이 있었다. 2명은 오심을 호소하였고 1명은 복약 초기 3일간의 수면장애를 호소하였다.

목차 (Table of Contents)

• CONTENTS
• List of Table ⅰ
• List of Figure ⅱ
• Ⅰ. INTRODUCTION 1
• Ⅱ. METHODS 4
• 1. Patients and Medication 4
• 1.1 Patients 4
• 1.2 Medication 6
• 1.3 Diet and Exercise Counseling 8
• 2. Measures 9
• 3. Safety 10
• 4. Statistical Analysis 11
• Ⅲ. RESULTS 12
• 1. Baseline characteristics of participants 14
• 2. Prescribed herbal decoctions 16
• 3. The changes of weight, height, BMI and OI in each treatment groups 18
• 4. The changes of weight, height, BMI and OI in pre-and post-treatment 21
• 5. The changes of physical activity and dietary intake 24
• 6. Safety 25
• Ⅳ. DISCUSSION 26
• Ⅴ. CONCLUSION 28
• REFERENCES 29
• ABSTRACT 34
• 한글초록 (In Korean) 35