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Aim of the study: Demineralized bone particle (DBP) was known to induce osteogenesis by osteoinduction, and has been used for bone regeneration in the oral and maxillofacial surgery. The aim of this study was to confirm the usefulness of the DBP/PLGA ...
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DBP/PLGA hybrid 지지체를 이용한 골견손부의 골재생 = Bone regeneration with DBP PLGA(Demineralized bone particle poly lactic co glycolic acid) hybrid scaffold
한글로보기https://www.riss.kr/link?id=T11560680
- 저자
-
발행사항
서울 : 고려대학교 임상치의학대학원, 2008
-
학위논문사항
학위논문(석사) -- 고려대학교 임상치의학대학원 , 구강악안면외과학 , 2008. 8
-
발행연도
2008
-
작성언어
한국어
- 주제어
-
발행국(도시)
서울
-
형태사항
vi, 19 p. : 삽도 ; 26cm.
-
일반주기명
단면인쇄임.
지도교수:장형석
참고문헌 : p.12-16 - DOI식별코드
-
소장기관
- 고려대학교 도서관
- 고려대학교 의학도서관
- 고려대학교 도서관
-
0
상세조회 -
0
다운로드
인용문이 복사되었습니다.
부가정보
다국어 초록 (Multilingual Abstract)
Aim of the study: Demineralized bone particle (DBP) was known to induce osteogenesis by osteoinduction, and has been used for bone regeneration in the oral and maxillofacial surgery. The aim of this study was to confirm the usefulness of the DBP/PLGA composite scaffold in bone tissue engineering.
Material & methods: DBP/PLGA scaffolds were prepared by solvent casting/salt leaching method. DBP/PLGA composite scaffold in fibrin gel was applied into rat cranial bone critical size defect (CSD:8mm in diameter). At 4, 8 weeks after implantation, new bone formation was evaluated by histological analysis of H-E staining and soft X-ray analysis.
Results: DBP/PLGA composite scaffolds in fibrin gel showed rapid and much more bone regeneration in rat cranial bone defects than PLGA graft group and no graft control group.
Conclusion: This results suggest the feasibility and usefulness of DBP/PLGA composite scaffold in bone tissue engineering.
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Key Words) Demineralized bone particle (DBP), DBP/PLGA composite scaffold, Rat cranial bone critical size defect, Bone tissue engineering.
Material & methods: DBP/PLGA scaffolds were prepared by solvent casting/salt leaching method. DBP/PLGA composite scaffold in fibrin gel was applied into rat cranial bone critical size defect (CSD:8mm in diameter). At 4, 8 weeks after implantation, new bone formation was evaluated by histological analysis of H-E staining and soft X-ray analysis.
Results: DBP/PLGA composite scaffolds in fibrin gel showed rapid and much more bone regeneration in rat cranial bone defects than PLGA graft group and no graft control group.
Conclusion: This results suggest the feasibility and usefulness of DBP/PLGA composite scaffold in bone tissue engineering.
------------------------------------------------------
Key Words) Demineralized bone particle (DBP), DBP/PLGA composite scaffold, Rat cranial bone critical size defect, Bone tissue engineering.
Aim of the study: Demineralized bone particle (DBP) was known to induce osteogenesis by osteoinduction, and has been used for bone regeneration in the oral and maxillofacial surgery. The aim of this study was to confirm the usefulness of the DBP/PLGA composite scaffold in bone tissue engineering.
Material & methods: DBP/PLGA scaffolds were prepared by solvent casting/salt leaching method. DBP/PLGA composite scaffold in fibrin gel was applied into rat cranial bone critical size defect (CSD:8mm in diameter). At 4, 8 weeks after implantation, new bone formation was evaluated by histological analysis of H-E staining and soft X-ray analysis.
Results: DBP/PLGA composite scaffolds in fibrin gel showed rapid and much more bone regeneration in rat cranial bone defects than PLGA graft group and no graft control group.
Conclusion: This results suggest the feasibility and usefulness of DBP/PLGA composite scaffold in bone tissue engineering.
------------------------------------------------------
Key Words) Demineralized bone particle (DBP), DBP/PLGA composite scaffold, Rat cranial bone critical size defect, Bone tissue engineering.
목차 (Table of Contents)
- I. 서론 1
- II. 연구재료 및 방법 2
- III. 연구결과 4
- Ⅳ. 총괄 및 고찰 5
- Ⅴ. 결론 10
- I. 서론 1
- II. 연구재료 및 방법 2
- III. 연구결과 4
- Ⅳ. 총괄 및 고찰 5
- Ⅴ. 결론 10
- Ⅵ. 참고 문헌 12
- 그림 및 그림부도 17
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