당뇨망막병증환자에서 전방내, 유리체내, 혈청내의 VEGF 및 PEDF농도 비교분석 = Analysis of VEGF and PEDF Concentration in Aqueous, Vitreous, Plasma of Diabetic Retinopathy Patient

다국어 초록 (Multilingual Abstract)

Purpose : To analyze the levels of vascular endothelial growth factor(VEGF) and pigment epithelium-derived factor(PEDF) in the aqueous, vitreous, plasma of patients with diabetic retinopathy(DR).

Methods : seventy eyes of 66 patients with diabetic retinopathy and 42 eyes of 40 patients with nondiabetic ocular disease as control subjects were analyzed. Diabetic retinopathy patients were divided into 3 group including nonproliferative diabetic retinopathy(NPDR group, n=21), posterior proliferative diabetic retinopathy(post. PDR group, n=38), anterior proliferative proliferative diabetic retinopathy(ant. PDR group, n=11). The concentration of VEGF and PEDF in the aqeous, vitreous, plasma were measured by enzyme linked immunosorbent assay(ELISA).

Results : The aqeous level of VEGF was significantly higher in ant. PDR group(P<0.05). The vitreous level of VEGF was significant higher in post. PDR group(P<0.05). The plama level of VEGF was higher in NPDR group(P<0.05). The PEDF concentration difference between groups in aqeous, vitreous, plasma were not statistically significant.

Conclusions : The VEGF concentration was higher in region of ocular tissue that active neovascularization exist. In diabetic retinopathy, the VEGF was significantly correlate with the neovascularization and more important than PEDF.

목차 (Table of Contents)

• 표목차 ------------------------------------------ ⅱ
• 도목차 ------------------------------------------ ⅲ
• 영문초록 --------------------------------------- ⅳ
• 서론------------------------------------------------ 1
• 대상과 방법------------------------------------------ 2
• 결과------------------------------------------------ 4
• 고찰------------------------------------------------ 5
• 참고문헌-------------------------------------------- 8