담석성 담낭염으로 오인된 담낭의 원발성 반지세포암 1예 = Primary Signet Ring Cell Carcinoma of the Gallbladder Mimicking Calculous Cholecystitis

다국어 초록 (Multilingual Abstract)

Signet ring cell carcinoma is a rare form of gallbladder cancer and has a worse prognosis. Since few cases have been reported, information regarding the behavior and prognosis of the gallbladder carcinoma is limited. About twenty four cases of gallbladder signet ring cell carcinoma have been reported so far. We present a rare case of primary signet ring cell carcinoma of the gallbladder. A 58-year-old male presented with epigastric pain. Abdominal computed tomography showed diffuse gallbladder wall thickening with enhancement, gallstones, and choledocholithiasis. After endoscopic treatment of choledocholithiasis, laparoscopic cholecystectomy was performed. Pathologic examination of the resected gallbladder revealed adenocarcinoma of signet ring cell type in the epithelium. Immunohistochemical stain for cytokeratin 7 was positive for tumor cells. The final pathologic diagnosis was primary signet ring cell carcinoma of the gallbladder. Lymph node metastasis was detected and he received chemotherapy and radiotherapy. After one year of follow-up, bone metastasis in the lumbar spine and malignant ascites were found. The patient is being provided with palliative care.
Korean J Pancreas Biliary Tract 2017;22(4):184-187

참고문헌 (Reference)

1 Lauwers GY, "WHO classification of tumors of digestive system" IARC Press 49-63, 2010

2 Ohno Y, "Signet-ring cell carcinoma of the gallbladder complicated by pulmonary tumor thrombotic microangiopathy" 53 : 1125-1259, 2014

3 Michal M, "Signet-ring cell aggregates simulating carcinoma in colon and gallbladder mucosa" 194 : 197-200, 1998

4 Yokota T, "Signet ring cell carcinoma of the stomach a clinicopathological comparison with the other histological types" 186 : 121-130, 1998

5 Pudasainin S, "Signet ring cell carcinoma of the gallbladder: a case report" 13 : 308-310, 2011

6 Tuncel D, "Poorly cohesive cell (diffuse-infiltraive/signet ring cell) carcinomas of the gallbladder: clinicopathological analysis of 24 cases indentified in 628 gallbladder carcinomas" 60 : 24-31, 2017

7 Yang XF, "Pathobiological behavior and molecular mechanism of signet ring cell carcinoma and mucinous adenocarcinoma of the stomach: a comparative study" 10 : 750-754, 2004

8 Sung-Chan Gwark, "Extent of resection for T2N0 gallbladder carcinoma regarding concurrent extrahepatic bile duct resection" 한국간담췌외과학회 16 (16): 142-146, 2012

9 Nagorney DM, "Carcinoma of the gallbladder and extra hepatic bile ducts" 15 : 106-115, 1988

10 Misra S, "Carcinoma of the gallbladder" 4 : 167-176, 2003

11 Misra NC, "Carcinoma gallbladder: recent advances in surgery" Churchill Livingstone 69-87, 1997

12 Suri VS, "Benign signet ring cell change with multilayering in the gallbladder mucosa--a case report" 197 : 785-788, 2001

13 Nishida T, "A human gall-bladder signet ring cell carcinoma cell line" 47 : 368-376, 1997

14 Pavić I, "A case of signet-ring cell carcinoma of the gallbladder: immunohistochemistry and differential diagnosis" 49 : 159-162, 2010

15 Minami Y, "A case of resected signet ring cell carcinoma arising from the gallbladder" 34 : 631-635, 2009