Thymus and activation-regulated chemokine (TARC)/CCL17 and IgE are associated with elderly asthmatics = 노년 천식환자에서 thymus and activation-regulated chemokine(TARC)/CCL17과 IgE의 관계

다국어 초록 (Multilingual Abstract)

The pathogenesis of asthma, which is an allergic lung disease, is associated with a variety of allergens such as house dust mite, pollen, and mould, IgE containing serum IgE and allergen-specific-IgE and inflammatory cytokines including thymus and activation-regulated chemokine (TARC)/CCL17. Because aging is an essential factor in the pathogenesis of asthma, I examined biomarkers related to asthmatic subjects depending on age.
Physiological indices such as FEV1 (forced expiratory capacity in 1 second), FEV1 (% predicted) and FEV1/FVC (forced vital capacity) (%) in asthmatic subjects were lower than those in normal subjects. Total IgE, Der p1 specific IgE and Der f1 specific IgE were elevated in serum of asthmatics relative to normal individuals. Regulated on activation normal T cell expressed and secreted (RANTES)/CCL5 and in serum and interleukin 6 (IL-6), interleukin 8 (IL-8), monocyte chemoattractant protein (MCP)-1/CCL2, RANTES and macrophage inflammatory protein (MIP)-1α/CCL3 in bronchoalveolar lavage fluid (BALF) of asthmatic subjects were higher than in normal individuals. Upon classification of experimental groups depending on age, physiological indices and Der p1-specific IgE (class) were decreased in middle aged asthmatic adults and elderly asthmatic adults groups relative to the young asthmatic adults group. TARC levels in serum were strongly elevated in the elderly asthmatic adults group relative to the middle aged asthmatic adults groups. TARC in serum was related to total IgE in serum in the elderly asthmatic adults group.
Taken together, although TARC in serum and BALF is not different between normal and asthmatic individuals, TARC increases in serum of elderly asthmatic subjects. The level of TARC has a positive effect on the level of IgE in the elderly asthmatic adults group. These findings may help us better understand the relationship of pathogenesis of allergic diseases and aging.

목차 (Table of Contents)

• ABSTRACT = ⅰ
• TABLE OF CONTENTS = ⅲ
• LIST OF TABLES = ⅳ
• Ⅰ. Introduction = 1
• Ⅱ. Materials and Methods = 3
• 1. Subjects = 3
• 2. Measurement Items = 3
• 3. Statistical Analysis = 6
• Ⅲ. Results = 7
• Ⅳ. Discussion = 16
• Ⅴ. Conclusion = 20
• References = 21
• 국문요지 = 26