수검제가 小腸內에서의 Sulfa劑 吸收에 미치는 影響 = (The) study on the influence of antidiarrhoics for the absorption of sulfnamides through the small intestine

다국어 초록 (Multilingual Abstract)

Auther examined the absorption of sulfonamides influencing to the such antidiarrhoics as the bismuth-subnitrats of heavy metal salt, and as the tannic acid of organic astringency by the Wiseman's apparatus, through the small intestine of rat.
The experiments carried out, two kinds of the concentration, the wateric buffor solution contained 0.5 mile - mole or 0.05 mili-mole of the each antidiarrhoics of the fixed administration of sulfonamides.
The views of the determined are as followings;
① Generally, the absorptions of sulfonamides are augmentation by their antidiarrhoics which the bismuth subnitrate effected than the tannic acid, and N'-(2-thiazolyl) sulfanilamido have been influenced than the N'-(6-methoxy 3-pyridazinyl) sulfonamide.
② The velocity constants of absorbability are 6.43×10^(-4) per a minute of N'-(2-thiazolyl) sulfonilamide and 5.80×10^(-4) per a minute of N'-(6-methoxy 3-pyridazinyl ) sulfonamide versus the bismuth subnitrate combined with the 0.05 mili-mole concentration, the higher concentration of the antidiarrhoics have practically tended than that of lower concentrations on the absorption rates.
③ According to the estimated value, N'-(2-thiazolyl) sulfanilamide are inhibited than the N'-(6-methoxy 3-pyridazinyl) sulfonamide by the combined drugr are fact that N'-(2-thiazolyl) sulfanilamide bismuth salt on the chemical structure.

목차 (Table of Contents)

• 목차 = 1
• Abstract = 2
• Ⅰ. Introduction = 4
• Ⅱ. Experimental = 5
• 1. 試料 = 5
• 2. Serosal 및 Mucosal 溶液의 調製 = 6
• 3. 實驗方法 = 6
• 4. Sulfanilamide의 定量 = 7
• Ⅲ. Result and Discussion = 9
• Ⅳ. Summary = 19
• Ⅴ. References = 20