뇌 수막종의 병리조직학적·면역조직화학적 및 중합효소 연쇄반응에 관한 연구 = Histopathological Study on the Intracranial Meningioma on the Basis of Immunohistochemical Staining and Polymerase Chain Reaction

다국어 초록 (Multilingual Abstract)

Meningioma is the most common primary intracranial neoplasm that originates from the meningothelial cells. It occurs mainly in the adults, and has female preponderance. It is classically classified as three main types : meningotheliomatous or syncytial type, fibrous or fibroblastic type, and transitional type. Transforming growth factor-α(TGF-α) was known as a neoplastic transformer found in the neoplastic tissue of the brain rather than normal tissue. In the neoplastic tissue, the expression of the TGF-α is more intense in the malignant rather than benign tumor, but, the expression on the meningioma was not reported. Transforming growth factor-β(TGF-β) was known as a peptide which is involved in the proliferation of the mesenchymal cells and the other many physiologic processes. Tumor necrosis factor(TNF) has a selective necrotic action of the neoplastic cells without influence on normal tissues. Epidermal growth factor(EGF) and epidermal growth factor receptor EGR have a control effect on cellular proliferation and differentiation, and the expression of the EGR in breast cancer has a reverse correlation to the expression of the estrogen receptor(ER). The meningioma is the most common host tumor of the breast cancer among the intracranial neoplasm, so, presence of some estrogen receptor in the meningioma is suspected. The correlation of the estrogen receptor expression to EGR expression in the meningioma is concerned.
Therefore, the author has observed the meningioma on the basis of the expression of the ER, TGF-α, TGF-β, TNF-R, EGF and EGR according to the immunohistochemical stain and polymerase chain reaction(PCR), and the results obtained were as follows.
The expressions of the TGF-a and TGF-β were weakly positive in 3 and 2 out of 25 cases examined, respectively and the expressions of the EGF and EGR were more intensely positive in 3 out of 25 cases examined, especially in the vascular wall and perivascular area. TNF-β expression was weakly positive to focal area only in one case of the meningotheliomatous and transitional type, respectively. The ER expression was weakly positive to focal areas in 2 out of 25 cases examined. The subtypes of meningioma expressing positivity were meningotheliomatous and transitional type, which were not related to the tumor aggressiveness and poor prognosis.
In conclusion, ER, TGF-α, TGF-β, TNF-β, EGF and EGR were expressed in the meningioma, and it is suspected that these factors may involved in the tumorigenesis or "host" tumor action rather than the tumor aggressiveness.

목차 (Table of Contents)

• 목차
• 表目次 = ⅱ
• 圖目次 = ⅲ
• ABSTRACT = 1
• Ⅰ. 서론 = 3
• Ⅱ. 연구재료 및 방법 = 5
• Ⅲ. 결과 = 9
• Ⅳ. 고찰 = 10
• Ⅴ. 결론 = 16
• REFERENCES = 17
• 사진부도 = 29