고지방식이와 운동강도 차이가 SD Rat의 혈중 인슐린, 혈당 및 혈중지질에 미치는 영향 = Effects of high fat diet and exercise intensity on plasma insulin, glucose and plasma lipids in Sprague-Dawley Rats

다국어 초록 (Multilingual Abstract)

This is study was to investigate the effects of high fat diet and exercise intensity on plasma insulin, glucose and plasma lipids in Sprague-Dawley rat. The 40 rats were randomly divided into 5 groups: control group (CON), high fat diet group (HF), high fat diet+low-intensity exercise group (HFLE, 22 m/min, 60 min, 6 days/week), high fat diet+moderate-intensity exercise group (HFME, 26 m/min, 51 min), high fat diet+high-intensity exercise group (HFHE, 30 m/min, 46 min). After 4-week high fat diet and endurance exercise training, the lipid profiles, insulin, glucose concentrations were determined in plasma. Plasma TC levels significantly increased in HF group compared to CON, and the exercise groups (HFLE, HFME, HFHE) were significantly low compared to HF group. The HDL-C level of HF group was significantly lower than the general group, and the three exercise groups significantly increased compared to the HF group. The TG concentration significantly increased in HF group compared to CON, and the exercise groups (HFLE, HFME, HFHE) significantly decreased compared to CON and HF group. Plasma glucose during OGTT in HF was significantly greater than that in CON, and plasma glucose in three exercise groups were significantly lower that those in CON and HF group at 30 and 60 min, respectively. Plasma insulin levels in three exercise (EX) groups were significantly decreased in 60min than that in HF. This study suggests that 4 weeks of high-fat diet caused insulin resistance on the whole body, and 4 weeks endurance exercise was shown effect in improving the blood lipid and insulin sensitivity. The differences of exercise intensities in the exercise groups were effective in decreasing the glucose, but did not have a significant difference in decreasing insulin. Therefore, in order to improve the blood lipid and insulin sensitivity, the exercise period and volume are the important factors, rather than the exercise intensity.

목차 (Table of Contents)

• 목 차
• I. 서 론 1
• 1. 연구의 필요성 1
• 2. 연구의 목적 3
• 3. 연구의 가설 3
• II. 이론적 배경 4
• 1. 비만과 대사성 증후군 4
• 2. 인슐린 저항성 6
• 3. 경구당부하검사 8
• 4. 신체활동이 인슐린과 혈당에 미치는 영향 10
• Ⅲ. 연구방법 12
• 1. 실험동물 12
• 2. 실험설계 13
• 3. 측정항목 및 방법 15
• 1) 경구당부하검사 15
• 2) 혈중지질 15
• 3) 혈당과 인슐린 16
• 4. 통계처리 17
• Ⅳ. 연구 결과 18
• Ⅴ. 논의 30
• Ⅵ. 결론 및 제언 34
• 참고문헌 36
• Abstract 40