A feasibility study of a visible/NIRF/gamma multi-modal laparoscope with SiPM-based gamma detection = 실리콘 광검출기 기반 감마선 검출을 이용한 가시광선/근적외선형광/감마선 융합복강경의 타당성 연구

다국어 초록 (Multilingual Abstract)

Recently, the cancer therapy has been greatly developed for radiation and chemotherapy method. However surgical resection is recommended for the majority of cancers. For this reason, intraoperative imaging study has emerged as surgical tools for identifying tumor margin. Intraoperative imaging has been studied using conventional image devices. The optical NIR image was acquired from fluorophore, and gamma and ultrasound image were acquired by using radioisotope tracer and ultrasound probe, respectively. However, each single modality has many limitations such as depth penetration, and spatial resolution. To overcome this limitation, multi-modality intraoperative imaging studies are ongoing. In multi-modality image, the gamma image was acquired by using CCD camera collecting scintillation photons from crystals. The CCD-based gamma image is difficult to evaluate gamma energy quantitatively. In this study, a multi-modal laparoscope was constructed. The SiPM-based gamma detector was constructed by using GATE Monte-Carlo simulation. The visible and NIR detectors consist of GRIN lens and CCD camera, respectively. The multi-modal laparoscope was used to evaluate the intrinsic performance of the gamma detector and simultaneous imaging was obtained. In future works, small animal experiment will be performed for the feasibility study of the multi-modal laparoscope.

목차 (Table of Contents)

• Ⅰ. INTRODUCTION = 1
• Ⅱ. MATERIALS AND METHODS = 4
• 1. Schematic of the Visible/NIRF/Gamma multi-modal system = 4
• 2. SiPM-based gamma dettector Monte-Carlo simulation = 6
• 3. SiPM-based gamma detector module = 8
• 4. Signal processing circuit and data analysis method of the multi-modal system = 10
• 5. Gamma image quantitative evaluation phantom experiment = 12
• 6. Optical image of multi-modal system = 14
• 7. Multi-modal imaging system experiment with ICG-99mTc mixture = 17
• Ⅲ. RESULTS = 19
• 1. SiPM-based gamma detector Monte-Carlo optical simulation = 19
• 2. Intrinsic performance of multi-modal system gamma detector = 20
• 3. Gamma image quantitative evaluation phantom experiment = 21
• 4. Optical image of multi-modal system = 23
• 5. Simultaneous gamma/NIRF/visible image of multi-modal system = 24
• Ⅳ. DISCUSSION = 25
• Ⅴ. CONCLUSION = 28
• REFERENCES = 29
• 국문요지 = 31