Ether, Fluothane 및 Methoxyflurane이 皮質下 中樞神經系統의 呼起反應에 미치는 影響 = The Effect of Ether, Fluothane and Methoxyflurane on Subcortical Evoked Central Nervous System Responses

다국어 초록 (Multilingual Abstract)

In twenty seven cats the effect of ether, fluothane and methoxyflurane on evoked potentials from the thalamus and reticular activating system of the midbrain have been recorded photographically.
These anesthetics all depressed the amplitude of the evoked responses affecting the midbrain reticular potentials to a greater degree than the thalamic potentials. In the concentrations utilized, methoxyflurane(1 per cent) proved the most potent in this regard, followed in order by fluothane(2 per cent) and ether (10 per cent). Conduction latency was unaffected in all cases.
The results suggest that the potency of these anesthetics is closely related to the suppression of the multisynaptic midbrain reticular system and support the concept that the general anesthetic state is associated with a reversible suppression of the midbrain ascending reticular activating system.
Of the three anesthetics studied, methoxyflurane affected most and fluothane least the direct thalamic system. Herein may be the explanation of why fluothane is not a potent analgesic.