各種 胃腸疾患에서 Carcinoembryonic antigen(CEA)의 診斷的 意義에 관한 硏究 = (A) Study on Diagnostic Significance of Carcinoembryonic Antigen(CEA) in Serum and Gastric Juice of Various Gastrointestinal Diseases

다국어 초록 (Multilingual Abstract)

Carcinoembryonic antigen(abbreviated as CEA) is one of the oncofetal protein in various malignant diseases and benign disorders.
Recently the titration of the CEA in fluids bathing tumors is used as complementary diagnostic method and therapeutic indicator.
This clinical study was performed in 117 cases, including gastric cancer (52 cases), gastric ulcer (15 cases), chronic gastritis (l5 cases), duodenal ulcer (l0 cases), and control group (25 cases), on the CEA titer of serum and gastric juice with radioimmunoassay kit.
1. In 25 control group, gastric CEA level(2.4±1.4ng/ml) was significantly higher than that(1.9±1.1ng/㎖) of serum, and CEA levels in both serum and gastric juice showed the tendency to increase by aging especially in 6th and 7th decade but not significantly.
2. In 25 control group, CEA levels of 10 smokers were significantly higher than those of 15 non-smokers in both serum and gastric juice.
3. The CEA levels of 52 gastric cancer group were significantly higher than those of any other group in both serum and gastric juice.
4. If all cases were scored using 2.5ng/ml as upper limit of normal, high incidence of false positive and negative of gastric cancer was noted, therefore 2.5ng/ml was seemed inappropriate as upper limit of CEA in normal serum. If upper limit of serum and gastric juice CEA levels were arbitrarily adjusted to mean +3SD of control group, diagnostic significance and sensitivity could be increased, especially in gastric juice.
Currently the diagnostic significance of CEA is not thought specific and sensitive as originally hoped. However this clinical study suggested that patients with high CEA level(> Mean+3SD of control) especially in gastric juice should be strongly suspected for the gastric cancer. In addition, CEA titration may limit but not totally negate its value as complementary diagnostic method of gastric cancer.

목차 (Table of Contents)

• 목차 = 1
• ABSTRACT = 3
• Ⅰ. 서론 = 5
• Ⅱ. 연구 대상 및 실험 방법 = 6
• Ⅲ. 연구 성적 = 7
• Ⅴ. 고안 = 18
• Ⅴ. 결론 = 24
• References = 26