형광 특성을 가진 단분산 야누스 미세구 합성에 대한 연구 = Synthesis of Monodispersed Janus Microspheres with Fluorescent Properties

다국어 초록 (Multilingual Abstract)

A Janus particle is a particle composed of two or more phases within one particle. Janus particles are applied in various fields such as surfactant for producing Pickering emulsions, drug delivery systems, and display devices due to their unique advantages that cannot be obtained from materials with uniform particle morphology and physical properties. Janus particles are mainly manufactured using masking, self-assembly, and phase separation methods. In this study, amphiphilic monodisperse Janus particles of several sizes were prepared using the seed swelling polymerization method, which is one of the phase separation methods. In addition, a method for imparting selective fluorescence properties to Janus particles and a method for manufacturing hemispherical particles were studied. To achieve this goal, spherical seed particles were first synthesized by dispersion polymerization and hydrolysis reaction. Then, Janus particles were prepared by utilizing the seed swelling polymerization method. The Janus particles with sizes of 2 μm, 4 μm, and 5 μm were prepared by adjusting the content of the synthetic material and the ratio of the dispersion medium in proportion to the size of the seed particles. Fluorescent Janus particles were synthesized through Steglich esterification of rhodamine B, a fluorescent dye, in the hydrophilic hemisphere of Janus particles. These fluorescent Janus particles had the advantage that they did not discolor even after repeated washing processes compared to the conventional fluorescent particles through swelling and diffusion. In addition, hydrophobic hemispherical particles were obtained by selectively dissolving the hydrophilic parts of Janus particles. The Janus particles prepared in this study could potentially be used in Pickering emulsions, particles for drug delivery systems, and optical biosensing.

목차 (Table of Contents)

• Ⅰ. 서론 1
• 1. 연구배경 1
• 2. 스테글릭 에스테르화 5
• 3. 로다민 B 7
• 4. 피커링 에멀션 9
• 5. 연구 목표 10
• Ⅱ. 실험 11
• 1. 시약 및 재료 11
• 2. 단분산 씨드 입자 제조 13
• 3. 야누스 입자 합성 16
• 4. 형광 야누스 입자 합성 18
• 5. 반구형 입자 제조 20
• 6. 피커링 에멀션 제조 22
• 7. 분석 23
• 1) 입자의 형태구조 분석 23
• 2) 화학 성분 함량 분석 23
• 3) 피커링 에멀션 현상 파악 23
• 4) 광학 특성 분석 24
• Ⅲ. 결과 및 고찰 25
• 1. 단분산 poly(St-co-VA) 씨드 입자 합성 25
• 2. 단분산 야누스 입자 합성 28
• 1) PS-co-PVA/PTA 구형 야누스 입자 제조 28
• 2) 분산 매질과 중합재료 함량이 야누스 입자에 미치는 영향 31
• 3) 씨드 입자의 가교 반응이 야누스 입자에 미치는 영향 37
• 4) 피커링 에멀션 40
• 3. 형광 야누스 입자 분석 43
• 1) 야누스 입자 착색 43
• 2) 탈색 시험 46
• 4. 반구형 입자 제조 48
• Ⅳ. 결론 50
• 참고 문헌 52