비강 및 부비동 종양에서 cyclooxygenase-2 및 matrix metalloproteinases의 발현 : 종양침습과 생성의 추정 = Cyclooxygenase-2 correlates with production and secretion of matrix metalloproteinases in sinonasal tumor : implication for tumor invasiveness and carcinogensis

다국어 초록 (Multilingual Abstract)

Purpose: The matrix metalloproteinases (MMPs) have been associated with tumor cell invasion and metastasis by mediating the degradation of extracellular matrix components. Cyclooxygenase-2 (COX-2) has an important role in promotion of carcinogenesis, tumor invasiveness and angiogenesis. Recently, some investigators have reported that COX-2 could promote secretion of MMP-2 and MMP-9. Therefore, an interrelation between MMPs and the associated COX-2 may play a significant role in the invasive phenotype of malignant tumors. In the present study, the author investigated the correlation between expressions of COX-2 and MMPs.
Materials and Methods: Immunohistochemical staining of MMP-2, -3 and -9, and COX-2 were performed on paraffin-embedded tissue sections of 51 nasal cavity and paranasal sinuses tumors(27 inverted papillomas, 5 inverted papillomas with malignant transformation, and 19 squamous cell carcinomas). Co-expression of these MMPs and COX-2 was visualized with confocal laser scanning microscope. Results: MMP-2, -3 and -9 were found mainly in malignant lesions in concert with COX-2. However, co-expression of only MMP-9 and COX-2 was detected with significancy.
Conclusion: These results suggest a potentially important role for COX-2 in the regulation of MMPs, malignant transformation, and progression of squamous cell carcinoma, and it points to the potential use of COX-2 inhibitors, in the prevention and therapy of squamous cell carcinoma of nasal cavity and paranasal sinuses.

목차 (Table of Contents)

• 목차
• 표목차 = i
• 도목차 = ii
• Abstract = 1
• 서론 = 3
• 연구재료 및 방법 = 5
• 결과 = 10
• 고찰 = 13
• 결론 = 22
• 참고문헌 = 23
• 표 및 사진부도 = 29