유기합성을 위한 마이크로웨이브와 연속 흐름 반응 기술 : N-알킬화와 친핵성 수산화반응 = Microwave and continuous flow reaction technology for organic synthesis : N-alkylation and nucleophilic aromatic hydrozylation

다국어 초록 (Multilingual Abstract)

There are many modern technologies to provide fast reaction, high yield, easy heat control, and rapid mixing for organic synthesis. In this thesis, we have focused on microwave and continuous flow reaction technology for N-alkylation and nucleophilic aromatic hydroxylation. Microwave reaction utilizing microwave irradiation has been recognized as a powerful tool for fast and efficient synthesis of organic compounds because of selective energy absorption by polar compounds. Secondly, an interest in continuous flow technology for organic synthesis is growing very fast in these days. Enhanced heat and mass transfer rates are intrinsic features of continuous flow reaction enabling chemical researchers to explore reactions that are traditionally difficult to investigate in common batch reactors. It provides powerful tools for studying highly energetic reactions with unstable intermediates. In this study, we applied microwave and continuous flow reaction technology for the synthesis of nitrogen-containing ionic liquids and utilized pack-bed reactor for nucleophilic aromatic hydroxylation reaction using solid KOH. The reaction time for N-alkylation reaction was dramatically reduced in both cases. For the synthesis of phenol, we applied super basic KOH/DMSO system in pack-bed reactor. Comparing flow reaction with batch reaction, reaction is completed in several minutes with high yields.

목차 (Table of Contents)

• 파트 Ⅰ 2
• 1. 서론 2
• 2. 결과 및 고찰 8
• 2-1. 마이크로웨이브 기술을 이용한 N-알킬화 반응 8
• 2-1-1. [BMIM][X]의 합성 9
• 2-1-2. 다양한 치환체 합성 10
• 2-1-3. sp3-질소의 알킬화 반응 13
• 2-1-4. Abnormal NHC-로듐 착물의 합성 19
• 2-2. 연속 흐름 기술을 이용한 N-알킬화 반응 15
• 2-2-1. [BMIM][X]의 합성 17
• 2-2-2. 다양한 치환체 합성 18
• 3. 결론 22
• 4. 실험 23
• 5. 참고문헌 42
• 파트 Ⅱ
• 1. 서론 45
• 2. 결과 및 고찰 48
• 2-1. 다양한 치환체 합성 51
• 3. 결론 52
• 4. 실험 53
• 5. 참고문헌 54