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Hepatitis B virus preS1 deletion is related to viral replication increase and disease progression
Baishideng Publishing Group Co 2015 WORLD JOURNAL OF GASTROENTEROLOGY Vol.21 No.16
<P>To investigate the clinical implications of hepatitis B virus (HBV) preS1 deletion.</P>
Eom, Bang Wool,Jung, So-Youn,Yoon, Hongman,Kook, Myeong-Cherl,Ryu, Keun Won,Lee, Jun Ho,Kim, Young-Woo Baishideng Publishing Group Co 2009 WORLD JOURNAL OF GASTROENTEROLOGY Vol.15 No.40
<P>We report a case of gastric choriocarcinoma admixed with an alpha-fetoprotein (AFP)-producing adenocarcinoma. A 70-year-old man was hospitalized for gastric cancer that was detected during screening by esophagogastroduodenoscopy (EGD). Initial laboratory data showed the increased serum level of AFP and EGD revealed a 5-cm ulcerofungating mass in the greater curvature of the gastric antrum. The patient underwent radical subtotal gastrectomy with D2 lymph node dissection and Billroth II gastrojejunostomy. Histopathological evaluation confirmed double primary gastric cancer: gastric choriocarcinoma admixed with an AFP-producing adenocarcinoma and separated adenocarcinoma. At 2 wk postoperatively, his human chorionic gonadotropin and AFP levels had reduced and six cycles of adjuvant chemotherapy were initiated. No recurrence or distant metastasis was observed at 4 years postoperatively.</P>