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Changes in metabolic syndrome in American and Korean youth, 1997-2008.
Lim, Soo,Jang, Hak Chul,Park, Kyong Soo,Cho, Sung Il,Lee, Man-Gyoon,Joung, Hyojee,Mozumdar, Arupendra,Liguori, Gary American Academy of Pediatrics [etc.] 2013 Pediatrics Vol.131 No.1
<P>Metabolic syndrome (MetSyn) in children and adolescence is increasing worldwide; however, its pattern may be different between Asians and Americans. We compare the prevalence and patterns of MetSyn between American and Korean children and adolescents between roughly 1998 and 2007.</P>
Osteopathic Manipulative Treatment for Pediatric Conditions: A Systematic Review
Posadzki, Paul,Lee, Myeong Soo,Ernst, Edzard American Academy of Pediatrics 2013 Pediatrics Vol.132 No.1
<P><B>BACKGROUND AND OBJECTIVES:</B></P><P>Most osteopaths are trained in pediatric care, and osteopathic manipulative treatment (OMT) is available for many pediatric conditions. The objective of this systematic review was to critically evaluate the effectiveness of OMT as a treatment of pediatric conditions.</P><P><B>METHODS:</B></P><P>Eleven databases were searched from their respective inceptions to November 2012. Only randomized clinical trials (RCTs) were included, if they tested OMT against any type of control in pediatric patients. Study quality was critically appraised by using the Cochrane criteria.</P><P><B>RESULTS:</B></P><P>Seventeen trials met the inclusion criteria. Five RCTs were of high methodological quality. Of those, 1 favored OMT, whereas 4 revealed no effect compared with various control interventions. Replications by independent researchers were available for 2 conditions only, and both failed to confirm the findings of the previous studies. Seven RCTs suggested that OMT leads to a significantly greater reduction in the symptoms of asthma, congenital nasolacrimal duct obstruction (posttreatment), daily weight gain and length of hospital stay, dysfunctional voiding, infantile colic, otitis media, or postural asymmetry compared with various control interventions. Seven RCTs indicated that OMT had no effect on the symptoms of asthma, cerebral palsy, idiopathic scoliosis, obstructive apnea, otitis media, or temporomandibular disorders compared with various control interventions. Three RCTs did not perform between-group comparisons. The majority of the included RCTs did not report the incidence rates of adverse effects.</P><P><B>CONCLUSIONS:</B></P><P>The evidence of the effectiveness of OMT for pediatric conditions remains unproven due to the paucity and low methodological quality of the primary studies.</P>
Postnatal Growth Following Prenatal Lead Exposure and Calcium Intake
Hong, Yun-Chul,Kulkarni, Surabhi Shah,Lim, Youn-Hee,Kim, Eunjeong,Ha, Mina,Park, Hyesook,Kim, Yangho,Kim, Bung-Nyun,Chang, Namsoo,Oh, Se-Young,Kim, Young-Ju,Park, Chooghee,Ha, Eun-hee American Academy of Pediatrics 2014 Pediatrics Vol.134 No.6
<P><B>BACKGROUND:</B></P><P>The effects on postnatal growth of maternal exposure to low levels of lead during pregnancy have not been well established. In addition, information is limited regarding the protective effect of dietary calcium intake during pregnancy against the effect of lead for fetal and postnatal growth. We investigated the relationship between prenatal exposure to lead and growth at birth and 6, 12, and 24 months postnatal, and evaluated the role of calcium intake against the effect of lead.</P><P><B>METHODS:</B></P><P>A total of 1150 pregnant women, and their subsequent offspring, enrolled in a prospective birth cohort study (Mothers and Children's Environmental Health Study), were evaluated. Multivariable regression analysis was conducted to estimate the effects of prenatal maternal blood lead levels on growth at each follow-up.</P><P><B>RESULTS:</B></P><P>The blood lead levels of participating mothers were <5.0 μg/dL and mean levels were 1.25 μg/dL during the early (before 20 gestational weeks) and late (at delivery) gestational periods. Prenatal exposure to lead, particularly in late pregnancy, was significantly associated with a reduction in infantile growth at 24 months. When pregnant women had dietary calcium intake at mean or upper level, the association was not significant. In contrast, lower than mean level of calcium intake intensified the adverse effect of prenatal lead exposure on growth in children.</P><P><B>CONCLUSIONS:</B></P><P>Prenatal lead exposure <5.0 μg/dL adversely affects postnatal growth and low calcium intake aggravates the effect, indicating more stringent control of lead and sufficient intake of calcium are necessary to help children’s health.</P>