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- 저자 : Yanwen Zhou (검색결과 2 건)
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A review on the failure behavior and countermeasures of thermal barrier coatings
Jiahang Liu,Zhe Lu,Yanwen Zhou,Jing Zhang,Guanlin Lyu 한양대학교 청정에너지연구소 2023 Journal of Ceramic Processing Research Vol.24 No.2
Thermal barrier coatings are widely used in high-temperature components in aircraft thrusters, power generation, and marineengines, enabling gas turbines to operate at elevated temperatures for extended periods by reducing the superalloys' surfacetemperature. During service, high-temperature oxidation, hot corrosion, and sintering occur inside the thermal barriercoatings, resulting in changes in the macro and microstructure of the coatings, and thermal-mechanical propertiesdegradation, eventually leading to coating failure. The main factors that lead to the failure of thermal barrier coatings andaffect the life of thermal barrier coatings are reviewed, including the formation of thermally grown oxides on the surface ofthe bond coat, the corrosion caused by the deposits on the surface of the coating and the sintering of the high-temperatureceramic layer, and the failure mechanism of the coating is analyzed. The countermeasures to prolong the service life of coatingsare reviewed from thermal barrier coating materials, coating structure, coating preparation methods, and post-treatment.
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Next‑Generation Sequencing‑Based Preimplantation Genetic Testing for De Novo NF1 Mutations
DongJia Chen,Xiaoting Shen,Yan Xu,Bing Cai,Chenhui Ding,Yiping Zhong,Yanwen Xu,Canquan Zhou 한국바이오칩학회 2021 BioChip Journal Vol.15 No.1
Neurofibroma type 1 (NFI) is an autosomal dominant genetic disease associated with cancer and cognitive dysfunction. The 50% de novo mutation rate and numerous mutation types of the NF1 gene pose challenges to preimplantation genetic testing (PGT) for NFI. In 2020, a couple was subjected to next-generation sequencing (NGS)-based PGT at our center. Both husband and wife carried de novo NF1 mutations. Biopsied trophectoderm samples underwent whole-genome amplification using multiple displacement amplification. NGS was conducted to detect NF1 mutations as well as 105 closely linked single-nucleotide polymorphisms (SNPs) flanking NF1. Since no affected family member was available, the affected embryos identified by NF1-targeted sequencing were assigned as probands, based on which a haplotype analysis was constructed with informative SNP sites. Sanger sequencing was administrated for verification. Aneuploidy screening through NGS was performed in the same PGT cycle. Finally, among the nine biopsied blastocysts, two unaffected and euploid blastocysts were obtained in the couple, and one of the blastocysts was transferred in a frozen–thawed embryo transfer (FET) cycle. The outcome of FET is under observation. This study is the first to apply NGS-based PGT for NFI. In cases of sporadic NFI cases without affected family members, NGS-SNP can perform haploid analysis in an accurate manner by assigning the affected embryos as probands.
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