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        Quantifying carotid stiffness in a pre-hypertensive population with ultrafast ultrasound imaging

        Xuehui Ma,Zhengqiu Zhu,Yinping Wang,Bixiao Shen,Xuezhong Jiang,Wenjun Liu,Yiyun Wu,Chong Zou,Yun Luan,Hui Gao,Hui Huang 대한초음파의학회 2023 ULTRASONOGRAPHY Vol.42 No.1

        Purpose: The aim of this study was to assess carotid stiffening in a pre-hypertensive (PHT) population using ultrafast pulse wave velocity (ufPWV). Methods: This study retrospectively enrolled 626 individuals who underwent clinical interviews, serum tests, and assessments of the systolic blood pressure (SBP), diastolic blood pressure (DBP), carotid intima-media thickness (cIMT), pulse wave velocity-beginning of systole (PWV-BS), and pulse wave velocity-end of systole (PWV-ES) between January 2017 and December 2021. The patients were divided into three groups according to their blood pressure (BP)—normal BP (NBP): SBP <130 mmHg and DBP <80 mmHg (n=215); PHT: 130 mmHg≤SBP<140 mmHg and/or 80 mmHg≤DBP<90 mmHg (n=119); hypertensive (HT): SBP ≥140 mmHg and/or DBP ≥90 mmHg (n=292). Correlation analyses and comparisons were performed among the groups and in the cIMT subgroups (cIMT ≥0.050 cm and <0.050 cm). Results: cIMT and PWV-ES significantly differed among the BP groups (P<0.05). The BP groups had similar PWV-BS when cIMT <0.050 cm or cIMT ≥0.050 cm (all P>0.05). However, the NBP group had a notably lower PWV-ES than the PHT (P<0.001 and P=0.024) and HT (all P<0.001) groups in both cIMT categories, while the PWV-ES in the PHT group were not significantly lower than in the HT group (all P>0.05). Conclusion: Carotid morphological and biomechanical properties in the PHT group differed from those in the NBP group. ufPWV could be used for an early evaluation of carotid stiffening linked to pre-hypertension.

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        An efficient time-variant reliability-based design optimization method based on probabilistic feasible region

        Zihao Wu,Zhenzhong Chen,Ge Chen,Xiaoke Li,Chen Jiang,Xuehui Gan,Haobo Qiu,Liang Gao 대한기계학회 2023 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.37 No.3

        Time-variant reliability-based design optimization (T-RBDO) issues are probabilistic design problems that assess the dependability of the design across time. The engineering situation is most closely resembled by it. The approaches to resolving T-RBDO problems, nevertheless, are convoluted and time-consuming. In this paper, an effective strategy for solving RBDO issues are extended to resolving TRBDO problems in order to increase efficiency. To solve T-RBDO challenges, the time-variant probabilistic feasible region (T-PFR) approach, which is based on the PFR method for resolving RBDO issues, was presented. The idea of the equivalent inverse most probable point (EIMPP) is put out in this methodology. Based on the EIMPP, the probabilistic feasible region is likewise developed for time-variant constraints. The effective tactic of the proposed method is to identify the non-active time-variant constraints using the probabilistic feasible region and to forego conducting time reliability analysis on them. Three mathematics and two engineering issues demonstrate that the suggested solution is viable and effective.

      • KCI등재

        A novel probabilistic feasible region method for reliability-based design optimization with varying standard deviation

        Zihao Wu,Zhenzhong Chen,Ge Chen,Xiaoke Li,Chen Jiang,Xuehui Gan,Haobo Qiu,Liang Gao 대한기계학회 2023 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.37 No.9

        An effective method for reliability-based design optimization (RBDO) problems taking uncertainties into account is the probabilistic feasible region (PFR) approach. The PFR approach is built around the fixed nature of the standard deviation in general RBDO problems. Therefore, the accuracy of the PFR approach will be affected when dealing with RBDO problems with varying standard deviation. To improve the accuracy of PFR method in solving the RBDO problems with varying standard deviation, a novel probabilistic feasible region strategy considering varying standard deviations (PFR-vstd) approach is suggested in this paper. In place of the initial probabilistic feasible region in standard normal space, a new probabilistic feasible region is established in original design space in this novel approach. The results of four applications demonstrate the high accuracy and sufficient efficiency of PFR-vstd method. The findings demonstrate that PFR-vstd method is capable of accurately resolving RBDO problems with varying standard deviation.

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        Leaching characteristics and curing mechanism of magnesium phosphate cement solidified zinc-contaminated soil in an acid rain environment

        Zhe Wang,Hangjun Zhu,Xuehui Wu,Binpin Wei,Hongli Zhou,Sifa Xu 대한환경공학회 2021 Environmental Engineering Research Vol.26 No.4

        A semi-dynamic leaching test was used to simulate the erosion effect of acid rain on magnesium phosphate cement (MPC)-stabilized/solidified zinc-contaminated soil. The leaching characteristics and curing mechanism were studied with a combination of X-ray diffraction (XRD) and scanning electron microscopy (SEM). Influences of the initial pH value of the simulated acid rain, the ratio of the curing agent (MgO/KH₂PO₄, abbreviated M/P), and the mass of water glass on the leaching characteristics of Zn<SUP>2+</SUP> and conductivity in the leachate of the sample were studied. It is shown that the curing effect of the cement component on Zn<SUP>2+</SUP> is better for M/P = 6 when compared to M/P = 4 in a strong acid environment. While in a weak acid environment, it is observed that the curing effect is superior when M/P = 4. Also it is observed that 4% water glass content can effectively improve the cement curing effect of heavy metal Zn in an acid rain environment. These results indicate that water glass can be effectively applied to MPC solidified heavy metal Zn.

      • KCI등재

        Carotid stiffening predicts cardiovascular risk stratification in mid-life: non-invasive quantification with ultrafast ultrasound imaging

        Zhengqiu Zhu,Lingshan Chen,Wenjun Liu,Yiyun Wu,Chong Zou,Xinyi Zhang,Shanshan He,Yinping Wang,Bixiao Shen,Xuehui Ma,Hui Gao,Yun Luan,Hui Huang 대한초음파의학회 2022 ULTRASONOGRAPHY Vol.41 No.3

        Purpose: The present study investigated the association between Systematic COronary Risk Evaluation (SCORE)-estimated cardiovascular risk and carotid stiffening in a middle-aged population using ultrafast pulse wave velocity (ufPWV).Methods: This study enrolled 683 participants without known cardiovascular disease or diabetes mellitus who underwent ufPWV measurements. Clinical interviews, physical examinations, laboratory findings, carotid intima-media thickness (cIMT), pulse wave velocity (PWV) at the beginning of systole (PWV-BS), and PWV at the end of systole (PWV-ES) were assessed. Each participant underwent an assessment of SCORE risk based on major cardiovascular risk factors (CVRFs), including age, sex, smoking, systolic blood pressure (SBP), and total cholesterol (TC). Crude and adjusted odds ratios (ORs) with 95% confidence intervals and ordinal logistic regression were used. Overall CVRFs were adjusted to assess ORs.Results: cIMT and carotid stiffening in PWV-BS and PWV-ES were significantly different between sex subgroups (all P<0.05), but only PWV-ES increased gradually in age and SCORE-estimated risk subgroups (all P<0.05). Compared with cIMT (r=0.388, P<0.001) and PWV-BS (r=0.159, P<0.001), PWV-ES was more strongly correlated with SCORE categories (r=0.405, P<0.001). Higher PWV-ES values were associated with SCORE categories independently of sex, SBP, TC, and smoking in moderate-risk and high-risk subgroups (OR, 1.63; P<0.001 and OR, 2.12; P=0.024, respectively), but were not independent of age in all risk subgroups (all P>0.05).Conclusion: Carotid stiffening quantified by ufPWV is linked to SCORE categories, and elevated PWV-ES may aid in cardiovascular risk stratification.

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