http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
- 中文 을 입력하시려면 zhongwen을 입력하시고 space를누르시면됩니다.
- 北京 을 입력하시려면 beijing을 입력하시고 space를 누르시면 됩니다.
RISS 인기검색어
- 검색키워드
- 저자 : Xie Jianxun (검색결과 1 건)
- 무료
- 기관 내 무료
- 유료
-
Jiang Tianyi,Kustermann Stefan,Wu Xiaoqin,Zihlmann Christine,Zhang Meifang,Mao Yi,Wu Waikwong,Xie Jianxun 대한독성 유전단백체 학회 2023 Molecular & cellular toxicology Vol.19 No.2
Background Antibiotics bear an inherent risk of mitochondrial toxicity due to the structural similarities between mitochondria and bacteria. Drug-induced mitochondrial dysfunction can contribute to organ toxicity and has resulted in a considerable number of market withdrawals. Fluoroquinolones were alerted for hepatotoxicity liability and were recently given black box warnings by FDA for the potential disabling side eff ects including tendonitis, pain in extremities and joints, neuropathies associated with paraesthesia, depression, impairment of memory, hearing, vision, etc. Objective In this study, the potential involvement of mitochondrial impairment in the toxicity of four fl uoroquinolones was investigated with a panel of mechanistic endpoints including ATP, mitochondrial respiration, as well as mitochondrial DNA and protein levels. Results Data revealed mitochondrial toxicity to diff erent extents, induced by the tested fl uoroquinolones and suggested mitochondrial protein synthesis as potential mechanism of action. Conclusion This study exemplifi es an integrated/holistic approach with a selected battery/panel of in vitro assays/endpoints serving to identify mitochondrial toxicity early on in the development of drugs, in particular, antibiotics.
연관 검색어 추천
이 검색어로 많이 본 자료
활용도 높은 자료
