Anti-Distortion Image Contrast Enhancement Algorithm Based on Fuzzy Statistical Analysis of the Histogram Equalization

Yao Nan,Wang KaiSheng,Cai Yue 보안공학연구지원센터 2016 International Journal of Signal Processing, Image Vol.9 No.4

In order to solve such problems as excessive enhancement and chessboard effect, difficult image brightness keeping and distortion in the image enhancement algorithm based on histogram equalization, an anti-distortion image contrast enhancement algorithm based on fuzzy statistics and sub-histogram equalization is proposed in this article. Specifically, the fuzzy set theory is introduced therein to convert the image into fuzzy matrix; then, by virtue of the membership function and the probability of the image gradation, the weighting function is embedded to construct the weighted fuzzy histogram calculation model; then, the mid-value of the initial image is adopted to divide the fuzzy histogram into two sub-histograms, and the corresponding cumulative density functions are defined, and the transformation models thereof are also constructed; then, the inverse transformation function is established to realize defuzzification and output the enhanced image. The experimental data show: compared with the present image enhancement algorithm based on histogram equalization, this algorithm can significantly eliminate excessive enhancement and noise amplification, thus to not only have better visual enhancement quality and anti-distortion performance, but also have maximum AIC (Average Information Contents) value and minimum NIQE (Natural Image Quality Evaluator) value.

Influence of Rear Earth Yb on the Specific Heat of Liquid Fe-Co-Yb Alloy

Yao, Wen Jing,Wang, Nan,Lee, Jeh Yun Trans Tech Publications 2013 Advanced materials research Vol.690 No.-

<P>By Monte Carlo method with EAM potentials, the specific heat of liquid Co50Fe50 and Co48Fe48Th4 alloys at different temperatures are obtained. The effect of Th on the thermophysical parameters is examined. Over the temperature range from 1400 to 2000 K, the specific heat decreases from to Jmol<SUP>-1</SUP>K<SUP>-1</SUP> after Th was added. It is the addition of Th element which has bigger atomic radius, larger atomic mass, and complex arrangement of extranuclear electron, leads to the reduced specific heat.</P>

Competition growth of α and β phases in Ti-50 at.%Al peritectic alloy during the rapid solidification by laser melting technique

Yao, Wenjing,Niu, Xiuling,Zhou, Long,Wang, Nan,Lee, Jehyun Springer-Verlag 2013 Acta metallurgica sinica Vol.26 No.5

Combination Doxorubicin and Interferon-α Therapy Stimulates Immunogenicity of Murine Pancreatic Cancer Panc02 Cells via Up-regulation of NKG2D ligands and MHC Class I

Wang, Wen-Jia,Qin, Si-Hao,Zhang, Ji-Wei,Jiang, Yue-Yao,Zhang, Jin-Nan,Zhao, Lei Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.22

Background: Pancreatic adenocarcinoma is a malignant gastrointestinal cancer with significant morbidity and mortality. Despite severe side effects of chemotherapy, the use of immunotherapy combined with chemotherapy has emerged as a common clinical treatment. In this study, we investigated the efficacy of the combined doxorubicin and interferon-${\alpha}$ (IFN-${\alpha}$) therapy on murine pancreatic cancer Panc02 cells in vitro and in vivo and underlying mechanisms. Materials and Methods: A Panc02-bearing mouse model was established to determine whether doxorubicin and interferon-${\alpha}$ (IFN-${\alpha}$) could effectively inhibit tumor growth in vivo. Cytotoxicity of natural killer (NK) cells and cytotoxic T lymphocytes (CTLs) was evaluated using a standard LDH release assay. To evaluate the relevance of NK cells and CD8 T cells to the combination therapy-mediated anti-tumor effects, they were depleted in tumor-bearing mice by injecting anti-asialo-GM-1 antibodies or anti-CD8 antibodies, respectively. Finally, the influence of doxorubicin+interferon-${\alpha}$ (IFN-${\alpha}$) on the ligands of NK and T cells was assessed by flow cytometry. Results: The combination therapy group demonstrated a significant inhibition of growth of Panc02 in vivo, resulting from activated cytotoxicity of NK cells and CTLs. Depleting CD8 T cells or NK cells reduced the anticancer effects mediated by immunochemotherapy. Furthermore, the doxorubicin+IFN-a treatment increased the expression of major histocompatibility complex class I (MHC I) and NKG2D ligands on Panc02 cells, suggesting that the combined therapy may be a potential strategy for enhancing immunogenicity of tumors. All these data indicate that the combination therapy using doxorubicin and interferon-${\alpha}$ (IFN-${\alpha}$) may be a potential strategy for treating pancreatic adenocarcinoma.

Solute Distribution Ahead of Interface during Heteroepitaxial Growth

Yao, Wen Jing,Jin, Zeng Jia,Wang, Nan,Lee, Jeh Yun Trans Tech Publications 2013 Advanced materials research Vol.690 No.-

<P>By establishing a diffusion model, the solute distribution is investigated during the growth of eutectic phase from the binary melt on the primary phase. Based on the eutectic reaction conditions, reasonable assumptions are carried out to build the partial differential equation. After the determination of the initial and boundary conditions, the analytical solutions have been derived from the method of variables separation. The solute distribution ahead of interface and the influence of this distribution on the growth rate of heteroepitaxial phase are discussed.</P>

Resveratrol Exerts Dosage-Dependent Effects on the Self-Renewal and Neural Differentiation of hUC-MSCs

Wang, Xinxin,Ma, Shanshan,Meng, Nan,Yao, Ning,Zhang, Kun,Li, Qinghua,Zhang, Yanting,Xing, Qu,Han, Kang,Song, Jishi,Yang, Bo,Guan, Fangxia Korean Society for Molecular and Cellular Biology 2016 Molecules and cells Vol.39 No.5

Resveratrol (RES) plays a critical role in the fate of cells and longevity of animals via activation of the sirtuins1 (SIRT1) gene. In the present study, we intend to investigate whether RES could promote the self-renewal and neural-lineage differentiation in human umbilical cord derived MSCs (hUC-MSCs) in vitro at concentrations ranging from 0.1 to $10{\mu}M$, and whether it exerts the effects by modulating the SIRT1 signaling. Herein, we demonstrated that RES at the concentrations of 0.1, 1 and $2.5{\mu}M$ could promote cell viability and proliferation, mitigate senescence and induce expression of SIRT1 and Proliferating Cell Nuclear Antigen (PCNA) while inhibit the expression of p53 and p16. However, the effects were reversed by 5 and $10{\mu}M$ of RES. Furthermore, RES could promote neural differentiation in a dose-dependent manner as evidenced by morphological changes and expression of neural markers (Nestin, ${\beta}III-tubulin$ and NSE), as well as pro-neural transcription factors Neurogenin (Ngn)1, Ngn2 and Mash1. Taken together, RES exerts a dosage-dependent effect on the self-renewal and neural differentiation of hUC-MSCs via SIRT1 signaling. The current study provides a new strategy to regulate the fate of hUC-MSCs and suggests a more favorable in vitro cell culture conditions for hUCMSCs-based therapies for some intractable neurological disorders.

Image Denoising Algorithm Based on Non Related Dictionary Learning

Yao Nan,Wang KaiSheng,Cai Yue 보안공학연구지원센터 2016 International Journal of Signal Processing, Image Vol.9 No.3

In allusion to the partial texture information loss during image deniosing process, an image denoising algorithm based on non related dictionary learning is proposed in this article. In this algorithm, the noise image is firstly divided into mutually overlapped image blocks, and a certain quantity of these image blocks are randomly selected for subsequent dictionary learning; then, non related dictionary learning technology is adopted to obtain the redundant dictionary with relatively strong irrelevance; finally, the sparse encoding algorithm is adopted to obtain the sparse representation coefficient of each image block in the redundant dictionary, and such sparse representation coefficients are used to recover the original image. The experiment result shows: since the redundant dictionary obtained through non related dictionary learning technology can strongly represent the image texture information, PSNR (Peak Signal to Noise Ratio) of the algorithm proposed in this article is superior to that of the existing advanced algorithm, and the algorithm can well keep the image detail and texture information, thus to improve visual effect.

Application of Intelligent Video Monitoring System in Electric Power Construction

Yao Nan,Wang KaiSheng,Cai Yue 보안공학연구지원센터 2016 International Journal of u- and e- Service, Scienc Vol.9 No.4

Since the image based intelligent video monitoring system has limited viewing angle, the blind monitoring zone will easily appear when the target is not in the field range of the camera. In order to solve the above problem, an intelligent video monitoring system with auditory function is proposed in this article on the basis of the advantages of sound localization. Firstly, the linear microphone array is acquired and the time delay estimation technology is adopted for sound localization; secondly, the camera is driven to turn to the sound source position to acquire video information; finally, the image detection program is adopted to locate and track the target in a real-time manner, and meanwhile the system feasibility is verified through the simulation experiment. The result shows that the system has good localization and tracking accuracy.

Prognostic Impact of Progesterone Receptor Status in Chinese Estrogen Receptor Positive Invasive Breast Cancer Patients

Nan Yao,Zhenchuan Song,Xinle Wang,Shan Yang,Heng Song 한국유방암학회 2017 Journal of breast cancer Vol.20 No.2

Purpose: Estrogen receptor (ER) and progesterone receptor (PR) have been used as indicators of endocrine system status since the mid-1970s in the clinical management of breast cancer. The predictive role of ER in endocrine therapy is undisputed, but the prognostic value of PR is still debated. The aim of this study was to investigate the clinical characteristics and prognosis of ER positive breast cancer with different PR expression levels. Methods: A population cohort of 3,030 primary invasive ER positive breast cancer patients from a single cancer center underwent surgery and received adjuvant endocrine therapy from 2004 to 2010. The clinical and biological features of these patients with high PR-expressing tumors were compared with those of patients with low PR-expressing tumors. The follow-up data for disease-free survival (DFS), overall survival (OS), and breast cancer specific survival (BCSS) was obtained from 2,778 patients. Cox regression analysis was used to correlate biomarkers and tumor characteristics with DFS, OS, and BCSS. Results: Tumors with low PR expression had more invasive pathological features and biological indexes than those with high PR expression. Low PR expression was an independent poor prognostic factor for DFS (p=0.014; hazard ratio [HR], 0.781; 95% confidence interval [CI], 0.641–0.950), OS (p=0.002; HR, 0.699; 95% CI, 0.560–0.873), and BCSS (p=0.005; HR, 0.714; 95% CI, 0.566–0.902). Furthermore, in low PR expressing tumors, patients who received chemotherapy had better DFS (p=0.002; HR, 0.449; 95% CI, 0.268–0.751), OS (p<0.001; HR, 0.341; 95% CI, 0.192–0.606), and BCSS (p<0.001; HR, 0.292; 95% CI, 0.156–0.549) than patients who did not received chemotherapy. Conclusion: Patients with ER positive invasive breast cancer with low PR expressing tumors have a worse prognosis than those with high PR expressing tumors, and these patients can benefit from chemotherapy.

Nano-eutectic growth in Co-17.8 wt%Gd alloy ribbons and the magnetostrictive properties at different wheel speeds.

Yao, Wen-Jing,Sun, Wen,Wang, Nan,Han, Seung Zeon,Lee, Je-Hyun American Scientific Publishers 2014 Journal of nanoscience and nanotechnology Vol.14 No.11

<P>Under near-equilibrium solidification conditions, the Co-17.8 wt%Gd eutectic alloy forms rod-like eutectic microstructure of (αCo) solid solution and Co17Gd2 compound. When the solidification condition is far from the equilibrium, the rapid growth of nano-eutectic in Co-17.8 wt%Gd alloy ribbons is realized by the single-roller techniques. The average granular size (d) of nano-eutectic in the center of ribbons varies with the increase of wheel speed (V), d = 510.36-25.51 V+0.44 V2. XRD results of ribbons at different wheel speeds indicate that, with the rise of wheel speed, the main peak of Co17Gd2 compound becomes more and more notable, whereas the main peak of (αCo) solid solution tends to reduce. Along the length direction, the Co-17.8 wt%Gd alloy ribbons have the negative magnetostrictive strain. The magnetostrictive strain enhances with the increase of wheel speed. At the wheel speed of 40 m/s, the magnetostrictive coefficient of ribbons is measured to be - 733 ppm at the magnetic field of 6 kOe. The influence of the wheel speed and the magnetic field on the maanetostrictive coefficient is discussed.</P>