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Nalidixic Acid Prodrugs: Amides from amino acid ester and nalidixic acid
Taori, Ashish,Nema, Rajesh,Kohli, D.V.,Uppadhyay, R.K. The Pharmaceutical Society of Korea 1991 Archives of Pharmacal Research Vol.14 No.1
Amides from amino acid ester and nalidixic acid were synthesized. The solubility characteristics and partition coefficient of the compounds were studied. The hydrolysis of the compounds was studied in the simulated gastric fluid and simulated intestinal fluid. Some compounds showed better antibacterial activity than nalidixic acid.
Designing of Antiepileptic Ligands by Esterification and Acetylation of Dipeptides
Vishwakarma, K.K.,Saraf, S.K.,Uppadhyay, R.K.,Kohli, D.V. The Pharmaceutical Society of Korea 1992 Archives of Pharmacal Research Vol.15 No.3
Glycylglycine, alanylalanine and alanylglycine were synthesized, their free carboxylic and amino groups were converted to methyl esters of N-acetylglycyglycine, N-acetylalanylglycine and N-acetylalanylalanine. The synthesized compounds were evaluated for antiepileptic activity, plasmaprotein binding, $TD_{50}$ and potentiating effect of phenobarbitone sodium.
Malonyl Amino Acids and Their Esters as Psychoactive Agents I
Jain, Dilip,Tripathi, Meena,Kohli, D.V.,Uppadhyay, R.K. The Pharmaceutical Society of Korea 1992 Archives of Pharmacal Research Vol.15 No.2
Malonic acid amides were synthesized using different amino acids and their esters. THe synthesized compounds were evaluated for their sedative activity on rats. Potentiating effect of all the compounds on pentobarbitone induced sleep on rats was observed. Plasma protein binding studies were also carried out and it was observed that the synthesized compounds have low plasma protein binding as compared to barbiturates.