http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
- 中文 을 입력하시려면 zhongwen을 입력하시고 space를누르시면됩니다.
- 北京 을 입력하시려면 beijing을 입력하시고 space를 누르시면 됩니다.
RISS 인기검색어
- 검색키워드
- 저자 : Tuna-Aguilar Elena Juventina (검색결과 2 건)
- 무료
- 기관 내 무료
- 유료
-
Warm autoimmune hemolytic anemia: experience from a single referral center in Mexico City
Hernandez-Company Alonso,Anguiano-Alvarez Victor Manuel,Carmona Gonzalez Carlos Amir,Rodriguez-Rodriguez Sergio,Pomerantz Allan,Lopez-Karpovitch Xavier,Tuna-Aguilar Elena Juventina 대한혈액학회 2017 Blood Research Vol.52 No.1
Background: Autoimmune hemolytic anemia (AIHA) is characterized by an autoimmune-mediated de-struction of red blood cells. Warm AIHA (wAIHA) represents 60% of AIHA cases and is associated with the positive detection of IgG and C3d in the direct antiglobulin test (DAT). This study aimed to assess the clinical and laboratorial differences between primary and secondary wAIHA patients from a referral center in Mexico City. Methods: All patients diagnosed with wAIHA in our institution from January 1992 to December 2015 were included and received corticosteroids as the first-line treatment. We analyzed the response to the first-line treatment, relapse-free survival, and time to splenectomy. Results: Eighty-nine patients were included. Secondary wAIHA represented 55.1% of the cases. At diagnosis, secondary wAIHA patients showed a DAT mixed pattern more frequently than primary wAIHA patients (36.7 vs. 17.5%, P<0.001). In the survival analysis, patients with secondary wAIHA had a lower time to response (18 vs. 37 days, P=0.05), median disease-free survival (28.51 vs. 50.95 weeks, P=0.018), and time to splenectomy (43.5 vs. 61 wks, P=0.029) than those with primary wAIHA. Due to economic constraints, ritux-imab was considered as the third-line treatment in only two patients. Conclusion: Secondary wAIHA may benefit from a longer low-dose steroid maintenance period mainly due to its shorter time to relapse and time to splenectomy than primary wAIHA.
-
Warm autoimmune hemolytic anemia: experience from a single referral center in Mexico City
Hernandez-Company Alonso,Anguiano-Alvarez Victor Manuel,Carmona Gonzalez Carlos Amir,Rodriguez-Rodriguez Sergio,Pomerantz Allan,Lopez-Karpovitch Xavier,Tuna-Aguilar Elena Juventina 대한혈액학회 2017 Blood Research Vol.52 No.1
Background: Autoimmune hemolytic anemia (AIHA) is characterized by an autoimmune-mediated de-struction of red blood cells. Warm AIHA (wAIHA) represents 60% of AIHA cases and is associated with the positive detection of IgG and C3d in the direct antiglobulin test (DAT). This study aimed to assess the clinical and laboratorial differences between primary and secondary wAIHA patients from a referral center in Mexico City. Methods: All patients diagnosed with wAIHA in our institution from January 1992 to December 2015 were included and received corticosteroids as the first-line treatment. We analyzed the response to the first-line treatment, relapse-free survival, and time to splenectomy. Results: Eighty-nine patients were included. Secondary wAIHA represented 55.1% of the cases. At diagnosis, secondary wAIHA patients showed a DAT mixed pattern more frequently than primary wAIHA patients (36.7 vs. 17.5%, P<0.001). In the survival analysis, patients with secondary wAIHA had a lower time to response (18 vs. 37 days, P=0.05), median disease-free survival (28.51 vs. 50.95 weeks, P=0.018), and time to splenectomy (43.5 vs. 61 wks, P=0.029) than those with primary wAIHA. Due to economic constraints, ritux-imab was considered as the third-line treatment in only two patients. Conclusion: Secondary wAIHA may benefit from a longer low-dose steroid maintenance period mainly due to its shorter time to relapse and time to splenectomy than primary wAIHA.
연관 검색어 추천
이 검색어로 많이 본 자료
활용도 높은 자료
