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- 저자 : Tiffany R. Chang (검색결과 2 건)
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Prince, Martin R.,Lee, Hae Giu,Lee, Chang-Hee,Youn, Sung Won,Lee, In Ho,Yoon, Woong,Yang, Benqiang,Wang, Haiping,Wang, Jin,Shih, Tiffany Ting-fang,Huang, Guo-Shu,Lirng, Jiing-Feng,Palkowitsch, Petra Springer Berlin Heidelberg 2017 EUROPEAN RADIOLOGY Vol.27 No.1
<P><B>Objectives</B></P><P>To investigate the safety and tolerability of gadobutrol at the recommended dose in patients requiring contrast-enhanced magnetic resonance imaging/angiography (MRI/MRA) in the routine setting.</P><P><B>Methods</B></P><P>GARDIAN prospectively enrolled 23,708 patients undergoing routine gadobutrol-enhanced MRI/MRA for approved indications at 272 study centres in Europe, Asia, North America, and Africa and monitored for adverse events.</P><P><B>Results</B></P><P>Median gadobutrol dose was 0.11 mmol/kg body weight. The overall incidence of adverse drug reactions (ADRs) was 0.7 % (<I>n</I> = 170 patients), with similar incidences in patients with renal impairment or cardiac disease, from different geographic regions and in different gadobutrol dose groups. Patients at risk for contrast media reaction had an ADR incidence of 2.5 %. Five patients (0.02 %) experienced serious adverse events, four were drug-related. One patient experienced a fatal anaphylactoid shock, assessed to be related to injection of gadobutrol. The contrast quality of gadobutrol-enhanced images was rated by treating physicians as good or excellent in 97 % cases, with similar ratings in all patient subgroups and indications.</P><P><B>Conclusions</B></P><P>The GARDIAN study shows that gadobutrol at the recommended dose is well tolerated across a large, diverse patient population.</P><P><B>Key points</B></P><P>• <I>Gadobutrol at recommended dose shows low rates of adverse drug reactions</I></P><P>• <I>Gadobutrol demonstrates a uniform safety profile across diverse patient groups</I></P><P>• <I>Gadobutrol provides excellent contrast quality in routine practice</I></P>
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Assessment and management of coagulopathy in neurocritical care
Ahmed M. Salem,David Roh,Ryan S. Kitagawa,Huimahn A. Choi,Tiffany R. Chang 대한신경집중치료학회 2019 대한신경집중치료학회지 Vol.12 No.1
Coagulopathy may be defined as the loss of balance between hemostatic and fibrinolytic processes resulting in excessive bleeding, intravascular thrombosis or abnormalities in coagulation testing. It is frequently encountered across a wide range of conditions seen in the neurocritical care unit and can contribute to poor outcomes. Early recognition and appropriate management are key, with traumatic brain injury, acute ischemic stroke, intracerebral hemorrhage, and subarachnoid hemorrhage presenting unique challenges to the neurointensivist. We will discuss techniques to assess coagulopathies as well as treatment strategies for the brain injured patient.
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