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- 저자 : Soogyeong Jang(장수경) (검색결과 1 건)
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Neurotoxicity of Butyl Paraben using Adult Zebrafish Behavior Assay
Jiwon Kim(김지원),Soogyeong Jang(장수경),Jiyune Kang(강지윤),Kitae Kim(김기태) 환경독성보건학회 2021 한국독성학회 심포지움 및 학술발표회 Vol.2021 No.5
Parabens are widely used in personal care products, pharmaceuticals, and food as preservatives due to their antimicrobial characteristics. Limited studies have reported the long-term exposure effect, in particular, on neurotoxicity of parabens. Butyl paraben (BuP) has been suggested to be the more toxic than methyl and ethyl parabens probably due to its relatively higher lipophilicity. In this study, we performed three behavior tests (i.e., novel tank, photomotor response and T-maze) with adult zebrafish upon the long-term exposure of BuP to evaluate neurotoxicity. Adult zebrafish were exposed for 28 days at three concentrations of BuP (i.e. 0.01, 0.1, and 1.0 mg/L). There were no significant alterations between BuP-exposed groups compared with the control group in the novel tank test, indicating no anxiety effect inducement. In contrast, we found that BuP reduced the mobility significantly at 1.0 mg/L and in transition of light/dark, the responsiveness of light decreased by 43% and 53% in each light photoperiod compared with control group. T-maze test revealed that the distance moved in enriched chamber (EC) decreased by 64% and 59% at 0.1 and 1.0 mg/L, respectively, and the cumulative time in EC decreased by 55% at 1.0 mg/L, indicating that the ability of learning and memory was interrupted by BuP exposure to zebrafish. Overall, our study demonstrate that BuP has a potential of neurotoxicity with respect to defects in mobility, the capacity of photosensation, and the cognitive function in adult zebrafish.
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