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RISS 인기검색어
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- 저자 : Simon R Hall (검색결과 3 건)
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Tepoerau Mai,Jordan Toullec,Simon Van Wynsberge,Marc Besson,Stephanie Soulet,Sylvain Petek,Emmanuelle Aliotti,Merrick Ekins,Kathryn Hall,Dirk Erpenbeck,David Lecchini,Mehdi A. Beniddir,Denis Saulnier 한국수산과학회 2019 Fisheries and Aquatic Sciences Vol.22 No.4
Marine natural products isolated from the sponge Fascaplysinopsis cf reticulata, in French Polynesia, were investigated as an alternative to antibiotics to control pathogens in aquaculture. The overuse of antibiotics in aquaculture is largely considered to be an environmental pollution, because it supports the transfer of antibiotic resistance genes within the aquatic environment. One environmentally friendly alternative to antibiotics is the use of quorum sensing inhibitors (QSIs). Quorum sensing (QS) is a regulatory mechanism in bacteria which control virulence factors through the secretion of autoinducers (AIs), such as acyl-homoserine lactone (AHL) in gramnegative bacteria. Vibrio harveyi QS is controlled through three parallel pathways: HAI-1, AI-2, and CAI-1. Bioassayguided purification of F. cf reticulata extract was conducted on two bacterial species, i.e., Tenacibaculum maritimum and V. harveyi for antibiotic and QS inhibition bioactivities. Toxicity bioassay of fractions was also evaluated on the freshwater fish Poecilia reticulata and the marine fish Acanthurus triostegus. Cyclohexanic and dichloromethane fractions of F. cf reticulata exhibited QS inhibition on V. harveyi and antibiotic bioactivities on V. harveyi and T. maritimum, respectively. Palauolide (1) and fascaplysin (2) were purified as major molecules from the cyclohexanic and dichloromethane fractions, respectively. Palauolide inhibited QS of V. harveyi through HAI-1 QS pathway at 50 μg ml–1 (26 μM), while fascaplysin affected the bacterial growth of V. harveyi (50 μg ml–1) and T. maritimum (0.25 μg). The toxicity of fascaplysin-enriched fraction (FEF) was evaluated and exhibited a toxic effect against fish at 50 μg ml–1. This study demonstrated for the first time the QSI potential of palauolide (1). Future research may assess the toxicity of both the cyclohexanic fraction of the sponge and palauolide (1) on fish, to confirm their potential as alternative to antibiotics in fish farming.
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Mai, Tepoerau,Toullec, Jordan,Wynsberge, Simon Van,Besson, Marc,Soulet, Stephanie,Petek, Sylvain,Aliotti, Emmanuelle,Ekins, Merrick,Hall, Kathryn,Erpenbeck, Dirk,Lecchini, David,Beniddir, Mehdi A.,Sau The Korean Society of Fisheries and Aquatic Scienc 2019 Fisheries and Aquatic Sciences Vol.22 No.12
Marine natural products isolated from the sponge Fascaplysinopsis cf reticulata, in French Polynesia, were investigated as an alternative to antibiotics to control pathogens in aquaculture. The overuse of antibiotics in aquaculture is largely considered to be an environmental pollution, because it supports the transfer of antibiotic resistance genes within the aquatic environment. One environmentally friendly alternative to antibiotics is the use of quorum sensing inhibitors (QSIs). Quorum sensing (QS) is a regulatory mechanism in bacteria which control virulence factors through the secretion of autoinducers (AIs), such as acyl-homoserine lactone (AHL) in gram-negative bacteria. Vibrio harveyi QS is controlled through three parallel pathways: HAI-1, AI-2, and CAI-1. Bioassay-guided purification of F. cf reticulata extract was conducted on two bacterial species, i.e., Tenacibaculum maritimum and V. harveyi for antibiotic and QS inhibition bioactivities. Toxicity bioassay of fractions was also evaluated on the freshwater fish Poecilia reticulata and the marine fish Acanthurus triostegus. Cyclohexanic and dichloromethane fractions of F. cf reticulata exhibited QS inhibition on V. harveyi and antibiotic bioactivities on V. harveyi and T. maritimum, respectively. Palauolide (1) and fascaplysin (2) were purified as major molecules from the cyclohexanic and dichloromethane fractions, respectively. Palauolide inhibited QS of V. harveyi through HAI-1 QS pathway at 50 ㎍ ml<sup>-1</sup> (26 μM), while fascaplysin affected the bacterial growth of V. harveyi (50 ㎍ ml<sup>-1</sup>) and T. maritimum (0.25 ㎍). The toxicity of fascaplysin-enriched fraction (FEF) was evaluated and exhibited a toxic effect against fish at 50 ㎍ ml<sup>-1</sup>. This study demonstrated for the first time the QSI potential of palauolide (1). Future research may assess the toxicity of both the cyclohexanic fraction of the sponge and palauolide (1) on fish, to confirm their potential as alternative to antibiotics in fish farming.
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Forming a thick CdZnTe epitaxial film by sublimating closely spaced
Xiang-Xiang Luoa,Cheng-Fang Qiao,Simon R Hall,Chun-Sheng Zhou 한양대학교 청정에너지연구소 2023 Journal of Ceramic Processing Research Vol.24 No.6
Thick Cadmium zinc telluride epitaxial films were grown on (100)GaAs substrate by Close-Spaced Sublimation. The growthrate was around 1 μm/min. SEM observations and XRD θ-2θ scan and ф scan revealed well-defined epitaxial features ofthe films. The films were found to be polycrystalline at the early stage of growth. As growth progressed, the films graduallybecame oriented until an epitaxial layer was formed. The polycrystalline to monocrystalline transition was achieved bypreferential lateral growth of the grains and with the aid of migration of atoms in the film. This growth mode differs fromthe well-established epitaxy where a suitable lattice fit is expected from the early stages of film growth. This mode can betterguide the growth mode of CZT thick films, and can grow large volume and high-quality thick films. High quality thick filmscan be better applied in fields such as solar cells, infrared and ultraviolet detection, and X-ray detection.
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