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女子는 괴로워 [비디오녹화자료]
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지향성 안테나기반 포아송 무선 네트워크에서의 간섭 분석
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외삽법을 이용한 풍화암에 근입된 현장타설말뚝의 극한하중 예측
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Design for Six Sigma and Lean Product Development : Differences^ Similarities and Links
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Etat des recherches sur les materiaux composites a matrice intermetallique a base de Ti~3Al et de TiAl
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Regista di Clausura: Lina Wertmueller and Her Feminism of Despair
- 검색키워드
- 저자 : Simon J G Lewis (검색결과 2 건)
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Luján Lidianys María Lewis,Rosas-Burgos Ema Carina,Brauer Josafat Marina Ezquerra,Burboa-Zazueta María Guadalupe,Assanga Simon Bernard Iloki,Castro Teresa del Castillo,Penton Giselle,Plascencia-Jatome 한국미생물·생명공학회 2022 Journal of microbiology and biotechnology Vol.32 No.8
Cephalopods, in particular octopus (Octopus vulgaris), have the ability to alter their appearance or body pattern by showing a wide range of camouflage by virtue of their chromatophores, which contain nanostructured granules of ommochrome pigments. Recently, the antioxidant and antimicrobial activities of ommochromes have become of great interest; therefore, in this study, the pH-dependent redox effect of the extraction solvent on the antioxidant potential and the structural characterization of the pigments were evaluated. Cell viability was determined by the microdilution method in broth by turbidity, MTT, resazurin, as well as fluorescence microscopy kit assays. A Live/ Dead Double Staining Kit and an ROS Kit were used to elucidate the possible inhibitory mechanisms of ommochromes against bacterial and fungal strains. The results obtained revealed that the redox state alters the color changes of the ommochromes and is dependent on the pH in the extraction solvent. Natural phenoxazinone (ommochromes) is moderately toxic to the pathogens Staphylococcus aureus, Bacillus subtilis, Salmonella Typhimurium and Candida albicans, while the species Pseudomonas aeruginosa and Pseudomonas fluorescens, and the filamentous fungi Aspergillus parasiticus, Alternaria spp. and Fusarium verticillioides, were tolerant to these pigments. UV/visible spectral scanning and Fourier- transform infrared spectroscopy (FTIR) suggest the presence of reduced ommatin in methanol/ HCl extract with high intrinsic fluorescence.
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Fighting Against the Clock: Circadian Disruption and Parkinson’s Disease
Yen-Chung Chen,Simon J G Lewis,Shey-Lin Wu 대한파킨슨병및이상운동질환학회 2024 Journal Of Movement Disorders Vol.17 No.1
Circadian disruption is being increasingly recognized as a critical factor in the development and progression of Parkinson’s disease (PD). This review aims to provide an in-depth overview of the relationship between circadian disruption and PD by exploring the molecular, cellular, and behavioral aspects of this interaction. This review will include a comprehensive understanding of how the clock gene system and transcription–translation feedback loops function and how they are diminished in PD. The article also discusses the role of clock genes in the regulation of circadian rhythms, as well as the impact of clock gene dysregulation on mitochondrial function, oxidative stress, and neuroinflammation, including the microbiota-gut-brain axis, which have all been proposed as being crucial mechanisms in the pathophysiology of PD. Finally, this review highlights potential therapeutic strategies targeting the clock gene system and circadian rhythm for the treatment of PD.
ScienceON
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