http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
- 中文 을 입력하시려면 zhongwen을 입력하시고 space를누르시면됩니다.
- 北京 을 입력하시려면 beijing을 입력하시고 space를 누르시면 됩니다.
RISS 인기검색어
- 검색키워드
- 저자 : Schieferstein, J. (검색결과 1 건)
- 무료
- 기관 내 무료
- 유료
-
Chemical and mechanical modulation of polymeric micelle assembly
Clay, N.,Whittenberg, J.,Leong, J.,Kumar, V.,Chen, J.,Choi, I.,Liamas, E.,Schieferstein, J.,Jeong, J.,Kim, D. Royal Society of Chemistry 2017 Nanoscale Vol.9 No.16
<P>Recently, polymeric micelles self-assembled from amphiphilic polymers have been studied for various industrial and biomedical applications. This nanoparticle self-assembly typically occurs in a solventexchange process. In this process, the quality of the resulting particles is uncontrollably mediated by polymeric solubility and mixing conditions. Here, we hypothesized that improving the solubility of an amphiphilic polymer in an organic solvent via chemical modification while controlling the mixing rate of organic and aqueous phases would enhance control over particle morphology and size. We examined this hypothesis by synthesizing a poly(2-hydroxyethyl) aspartamide (PHEA) grafted with controlled numbers of octadecyl (C18) chains and oligovaline groups (termed 'oligovaline-PHEA-C-18'). The mixing rate of DMF and water was controlled either by microfluidic mixing of laminar DMF and water flows or through turbulent bulk mixing. Interestingly, oligovaline-PHEA-C18 exhibited an increased solubility in DMF compared with PHEA-C18, as demonstrated by an increase of mixing energy. In addition, increasing the mixing rate between water and DMF using the microfluidic mixer resulted in a decrease of the diameter of the resulting polymeric micelles, as compared with the particles formed from a bulk mixing process. Overall, these findings will expand the parameter space available to control particle self-assembly while also serving to improve existing nanoparticle processing techniques.</P>
연관 검색어 추천
이 검색어로 많이 본 자료
활용도 높은 자료
