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- 저자 : Satapathy Kunja Bihari (검색결과 2 건)
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Potential bioactive molecules from natural products to combat against coronavirus
Singh Yengkhom Disco,Barsarani Jena,Rina Ningthoujam,Panda Sneha,Priyadarsini Pratigyan,Sabita Pattanayak,Manasa Kumar Panda,Singh Mayanglambam Chandrakumar,Kunja Bihari Satapathy 경희대학교 융합한의과학연구소 2022 Oriental Pharmacy and Experimental Medicine Vol.22 No.2
Covid-19 is terribly spreading around the globes and there is no stoppage. It is causing mass destruction in mankind allowing them to lock inside home to contain the disease. At present, there are no remedial medicines, drugs, or vaccines available in the market. Researchers are trying their best level to produce drugs to fight againts the disease. Various efforts are being considered by using different directions of scientific knowledge and technologies on treating the disease. The existing antiviral drugs such as lopinavir/ritonavir, pitavastatin, nelfinavir, perampanel, and praziquantel are being administered as remedies of covid-19 patients. Unfortunately, none of these drugs works absolutely against the current pandemic. Therefore, bioactive molecules from plants, animals, and microorganisms could be a better option to treat against the covid-19 and its family. Plants can treat many diseases due to the presence of bioactive molecules and their antiviral properties. Presence of secondary metabolites such as flavonoids, alkaloids, terpenoids, polyphenols, curcumin, kaempferol, catechin, naringenin, quercetin, apigenin-7-glucoside, luteolin-7-glucoside, demethoxycurcumin, oleuropein, and epigallocatechin can fight against the coronavirus including covid-19. The listed plants such as litchi seeds, Houttuynia cordata, Chinese Rhubarb extracts, beta-sistosterol from Isatis indigotica root extract have capacity to obstruct the enzymatic activity of SARS. In this article, we have highlighted the bioactive molecules from different plants, animals, and microorganism and their potential activity against the coronavirus. It is a need of the hour to come together to explore more on such bioactive compounds of plants, animals and other microorganism to fight against the covid-19.
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Bioactive molecules from plants: a prospective approach to combat SARS-CoV-2
Gagan Kumar Panigrahi,Shraban Kumar Sahoo,Sahoo Annapurna,Shibasish Behera,Sahu Snigdharani,Dash Archana,Satapathy Kunja Bihari 경희대학교 융합한의과학연구소 2023 Oriental Pharmacy and Experimental Medicine Vol.23 No.3
The emergence of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) or 2019 Novel Coronavirus (2019-nCoV) has put the entire globe into unrest, primarily due to unavailability of specific drug against the viral proteins. In the last two decades the world has withstood many contagious disease crashes. SARS-CoV-2 has put the world and the mankind in danger. It is spreading unstoppably all over the world. The virus is evolving and thus the pathogenicity of SARS-CoV-2 strains has been different and making it difficult to develop a broad-spectrum anti-viral molecule that would be effective against all the SARS-CoV-2 variants. This imperative situation demands development of molecules for effective treatment against SARS-CoV-2. The phytomolecules or the bioactive molecules of plants could be a great alternative to combat SARS-CoV-2. The bioactive molecules with their antiviral properties and the secondary metabolites may effectively deactivate the functioning of viral proteins. The structural configuration of 2019-nCoV proteins and genomic information are available, thus contributing immensely for fast molecular docking studies and hence, enables screening of numerous accessible phytomolecules. In the current study, we have essentially highlighted common phytomolecules against the known viral proteins and described the mode of action of few plant-derived molecules which have the potential to suppress the activity of the viral proteins.
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