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- 저자 : Sammour Omaima A. (검색결과 2 건)
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Abdel-Hafez Salma M.,Hathout Rania M.,Sammour Omaima A. 경희대학교 융합한의과학연구소 2021 Oriental Pharmacy and Experimental Medicine Vol.21 No.1
For the past few years, curcumin has drawn the attention of scientists in multidisciplinary fields related to oncology and therapeutics. However, despite its high potency, its delivery suffers from several limitations and challenges that hinders the complete benefit from this magical molecule. Accordingly, this review demonstrates the several attempts and endeavors that the scientists exerted in order to delivery this molecule successfully through the transdermal route. We believe that the transdermal route of delivery of drugs can pose a new platform of targeting solid tumors such as the breast carcinoma so that applying a transdermal patch over the skin or the membrane covering the solid tumor can provide a means of the cure.
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Khaled S. Shamarekh,Heba A. Gad,Mahmoud E. Soliman,Omaima A. Sammour 한국약제학회 2020 Journal of Pharmaceutical Investigation Vol.50 No.2
Purpose The aim of the present study was to prepare gelatin nanoparticles (GNPs) using modified one step desolvation method to obtain small, uniformly sized, and spherical GNPs. Methods The modifications involved the preparation of high molecular weight gelatin (HMWG) by fractionation of gelatin. HMWG was freeze-dried to be used in a specified concentration for preparation of GNPs with controllable properties. Furthermore, HMWG was cationized by dissolving it in acidified deionized water at pH value less than its isoelectric point. Factorial design analysis was utilized to investigate the effect of different preparation variables (viz. HMWG concentration, pH and ratio of HMWG solution volume to non-solvent volume) on particle size, polydispersity index (PDI), zeta potential and yield of GNPs. Results Results revealed the formation of monodisperse GNPs with small particle size, low PDI values (< 0.2) and high yield. FT-IR spectroscopy and differential scanning calorimetry studies revealed that the conformational structure of HMWG chains was altered within GNPs matrices. Conclusion The suggested modifications introduced on the one-step desolvation method enable to prepare successfully monodispersed GNPs with narrow size distribution and high particle yield.
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