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- 저자 : Salvador Arias-Santiago (검색결과 1 건)
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Bone and Metabolic Markers in Women With Recurrent Calcium Stones
Miguel Angel Arrabal-Polo,Miguel Arrabal-Martin,Salvador Arias-Santiago 대한비뇨의학회 2013 Investigative and Clinical Urology Vol.54 No.3
Purpose: The target of our work was to study several biochemical parameters in phospho-calcic and bone metabolism in blood and urine and the bone mineral density of women with recurrent calcium nephrolithiasis. Materials and Methods: We conducted a cross-sectional study with a control group of 85 women divided into 3 groups: group 1 consisted of 25 women without a history of nephrolithiasis, group 2 consisted of 35 women with only one episode of calcium nephrolithiasis,and group 3 consisted of 25 women with a history of recurrent calcium nephrolithiasis. Blood and urine biochemical study was performed, including markers related to lithiasis, and a bone mineral density study was done by use of bone densitometry. Results: Patients in group 3 showed statistically significantly elevated calciuria (15.4mg/dL), fasting calcium/creatinine ratio (0.14), and 24-hour calcium/creatinine ratio (0.21) compared with groups 1 and 2. Moreover, this group of women with recurrent calcium nephrolithiasis had significantly elevated values of beta-crosslaps, a bone resorption marker, compared with groups 1 and 2 (p=0.000) and showed more bone mineral density loss than did these groups. Conclusions: Recurrent calcium nephrolithiasis in women has a significant association with bone mineral density loss and with values of calciuria, both fasting and 24-hour.
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