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- 검색키워드
- 저자 : Pedro Filho Noronha Souza (검색결과 2 건)
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Pedro Filho Noronha Souza,Fabricio Eulálio Leite Carvalho 한국식물학회 2019 Journal of Plant Biology Vol.62 No.3
As simple organisms with a parasite nature,viruses have become masters in manipulating and subvertcellular components, including host proteins and organelles,to improve viral replication. Therefore, the understanding ofviral strategies to manipulate cell function disrupting plantdefenses and enhancing viral infection cycles is fundamentalto the production of virus-resistant plant lines. After invadingsusceptible plants, viruses create conditions that favor localand systemic infections by suppressing multiple layers ofinnate host defenses while use cellular machinery to ownbenefit. Viral interference in interlinked essential cellularfunctions results in phenotypic changes and disease symptoms,which debilitates plants favoring infection establishment. Herein in this review, the novelty it will be the discussionabout the strategies used by (+) single strand RNA viruses toaffect cellular processes and components to improve viralreplication, in parallel to overcome plant defenses, favoringdisease establishment by applying in one action using thesame viral protein to coordinate viral replication and breakingdown plant defense. This focus on plant-virus interactionwas never done before, and this knowledge has the potentialto help in the development of new strategies to produceresistant plants.
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Wound dressing using graphene quantum dots: a proof of concept
Martins Vanessa Gonzalez Ferreira Caminha,Alencar Luciana Magalhaes Rebelo,Souza Pedro Filho Noronha,Lorentino Carolinne Margot Albanez,Frota Heloisa Freire,dos Santos Andre Luis Souza,Gemini-Piperni 한국약제학회 2023 Journal of Pharmaceutical Investigation Vol.53 No.2
Purpose The costs and complexity related to effective wound healing treatment are immense. The number of multifactorial aspects related to the treatment of wounds (inflammation, infection, and many others) implies a complex multi-therapeutic approach involving various procedures, including medication and surgery. Regarding medication, there are only a few options, especially to treat chronic wounds. Recently graphene quantum dots have been applied for their potent antimicrobial properties as well as their significant tissue remodeling properties. In this study, we developed a formulation based on graphene quantum dots in the form of as a dry powder for wound healing. Methods Graphene quantum dots were produced by top-down technique using graphite as matrix, and fully characterized by Raman spectroscopy, atomic force microscopy, and X-ray diffractometry. The dry powder formulation was produced under aseptic conditions and evaluated in vitro and in vivo. Results The results showed that the formulation improved the healing process in both: in vitro and in vivo, with good adherence, healing time and tissue reconstruction. Finally, the results demonstrated that dry powder was very effective against P. aeruginosa, S. epidermidis, C. albicans and C. tropicalis, representing an improvementfor wound healing purposes. Conclusion The data corroborated the use of the dry powder formulation using graphene quantum dots as matrix as wound dressing, expanding the use of graphene quantum in the biomedical field.
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