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El-Diwani, H.I.,Nakkady, S.S.,El-Shabrawy, O.,Gohar, A-K.M.N.,Hishmat, O.H. The Pharmaceutical Society of Korea 1988 Archives of Pharmacal Research Vol.11 No.1
Several 4-cyano-1-benzofuranyl-1-butanone derivatives were synthesized and screened for potential antiinflammatory and analgesic activities. The effect of structural variation of these molecules on biological activities was systematically examined. Among these compounds $V_a,\;V_c\;and\;VI_e$ were found to demonstrate a significant antiinflammatory effect. Compounds $VI_e,\;V_a,\;I_d,\;I_band\;VII_f$ were also significantly effective as analgesic ones.
Synthesis and Biological Activities of New Substituted Indoles
Hishmat, Orchidee H.,Nakkady, Sally S.,El Shabrawy, Osama A.,Mahmoud, Sawsan S. The Pharmaceutical Society of Korea 1992 Archives of Pharmacal Research Vol.15 No.1
2, 3-Diphenyl-6-formyl-5-methoxyindole reacts with ethyl cyano acetate to yield the arylidene derivative which forms with urea and thiourea the corresponding pyrimidine derivatives. The arylidene derivatives react with hydrazines and with active methylenes to form the respective pyrazole derivatives and the $\alpha, \;\beta$-disubstituted acrylonitriles. Seven new compounds were tested for their effects on the arterial blood pressure of rats and analgesic activity.